CRCGN017_MCF10A.WT.HP_24H:J19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-acetylaminobiphenyl 100.52 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

134 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 5.78495
NANOS3 nanos homolog 3 (Drosophila) 5.1297
AGR2 anterior gradient 2 4.7172
SNAP25 synaptosomal-associated protein, 25kDa 4.65368
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.63053
CCP110 centriolar coiled coil protein 110kDa 4.4684
AXIN1 axin 1 4.4399
OLFML2B olfactomedin-like 2B 3.94435
TIAM1 T-cell lymphoma invasion and metastasis 1 3.41372
ACAA1 acetyl-CoA acyltransferase 1 3.33075
SOX2 SRY (sex determining region Y)-box 2 3.29085
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.17095
RLIM ring finger protein, LIM domain interacting 3.06095
PABPC3 poly(A) binding protein, cytoplasmic 3 2.8658
WIF1 WNT inhibitory factor 1 2.828
AGTPBP1 ATP/GTP binding protein 1 2.4966
OGDHL oxoglutarate dehydrogenase-like 2.4234
TMED3 transmembrane emp24 protein transport domain containing 3 2.4201
ACTA2 actin, alpha 2, smooth muscle, aorta 2.38245
CHUK conserved helix-loop-helix ubiquitous kinase 2.353
NEFM neurofilament, medium polypeptide 2.3351
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.32685
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 2.31405
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2.29405
PMP2 peripheral myelin protein 2 2.234
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.23195
CTSZ cathepsin Z 2.2301
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.22835
COQ8A coenzyme Q8A 2.20695
POU3F2 POU class 3 homeobox 2 2.2004
CALB1 calbindin 1, 28kDa 2.18027
ELOVL2 ELOVL fatty acid elongase 2 2.17877
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 2.1724
TPD52L2 tumor protein D52-like 2 2.1545
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 2.1487
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.13812
PCYOX1 prenylcysteine oxidase 1 2.1349
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.12
ABHD2 abhydrolase domain containing 2 2.11726
RAI1 retinoic acid induced 1 2.116
CCNO cyclin O 2.1135
CCL13 chemokine (C-C motif) ligand 13 2.11145
COL9A3 collagen, type IX, alpha 3 2.1028
DPEP1 dipeptidase 1 (renal) 2.0811
CDC42SE1 CDC42 small effector 1 2.07265
TRIM9 tripartite motif containing 9 2.06475
JPT1 Jupiter microtubule associated homolog 1 2.0444
PLIN3 perilipin 3 2.0397
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2.00225

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -7.48485
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.86855
SGK1 serum/glucocorticoid regulated kinase 1 -4.7046
YME1L1 YME1-like 1 ATPase -4.31532
TRAPPC3 trafficking protein particle complex 3 -4.0821
VDAC1 voltage-dependent anion channel 1 -3.9818
COPS7A COP9 signalosome subunit 7A -3.83785
TENT4A terminal nucleotidyltransferase 4A -3.3776
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.2835
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -3.25805
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -3.2005
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -3.1064
MSN moesin -2.8887
TUBA4A tubulin, alpha 4a -2.8396
CDK14 cyclin-dependent kinase 14 -2.66235
ATAD5 ATPase family, AAA domain containing 5 -2.6239
ZC3H12A zinc finger CCCH-type containing 12A -2.555
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -2.544
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.52545
STEEP1 STING1 ER exit protein 1 -2.4999
ANO2 anoctamin 2, calcium activated chloride channel -2.4841
PRR14L proline rich 14-like -2.46265
FANCG Fanconi anemia, complementation group G -2.46185
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.39355
ZNF514 zinc finger protein 514 -2.3855
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.36925
STEAP4 STEAP family member 4 -2.3248
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.32295
MAVS mitochondrial antiviral signaling protein -2.31315
MRPS15 mitochondrial ribosomal protein S15 -2.31195
CUL1 cullin 1 -2.2942
FOXF1 forkhead box F1 -2.2878
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -2.26557
SH2D4A SH2 domain containing 4A -2.2569
SHOX short stature homeobox -2.24735
RTL8A retrotransposon Gag like 8A -2.24445
ZBTB7C zinc finger and BTB domain containing 7C -2.2428
LIPF lipase, gastric -2.2405
ZNF500 zinc finger protein 500 -2.23968
LMO7 LIM domain 7 -2.2336
CORO2A coronin, actin binding protein, 2A -2.2239
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.2235
PLEK pleckstrin -2.22318
DUOX2 dual oxidase 2 -2.1795
METTL22 methyltransferase like 22 -2.1714
OSER1 oxidative stress responsive serine-rich 1 -2.1681
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.1534
PKD2L2 polycystic kidney disease 2-like 2 -2.1441
FFAR2 free fatty acid receptor 2 -2.1428
DCAF1 DDB1 and CUL4 associated factor 1 -2.14167
POM121 POM121 transmembrane nucleoporin -2.14095
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -2.1352
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -2.13443
MBOAT2 membrane bound O-acyltransferase domain containing 2 -2.1331
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.1224
CDK11A cyclin-dependent kinase 11A -2.11495
LOXL2 lysyl oxidase-like 2 -2.11388
RAD54L RAD54-like (S. cerevisiae) -2.11135
RNF146 ring finger protein 146 -2.111
KCMF1 potassium channel modulatory factor 1 -2.10875
ZHX2 zinc fingers and homeoboxes 2 -2.0964
CBLIF cobalamin binding intrinsic factor -2.094
GSTCD glutathione S-transferase, C-terminal domain containing -2.08875
SCAF4 SR-related CTD-associated factor 4 -2.08052
IL11RA interleukin 11 receptor, alpha -2.06735
FOXF2 forkhead box F2 -2.0654
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -2.0554
FAIM Fas apoptotic inhibitory molecule -2.05005
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.049
CMC4 C-x(9)-C motif containing 4 -2.04783
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -2.0477
PEF1 penta-EF-hand domain containing 1 -2.0469
PRH1-TAS2R14 PRH1-TAS2R14 readthrough -2.0462
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -2.0338
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) -2.0301
CDH8 cadherin 8, type 2 -2.02953
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -2.0275
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.0227
COL8A2 collagen, type VIII, alpha 2 -2.02082
FPR2 formyl peptide receptor 2 -2.01675
HLA-DOB major histocompatibility complex, class II, DO beta -2.01175
MOGS mannosyl-oligosaccharide glucosidase -2.00735
HSPB3 heat shock 27kDa protein 3 -2.0057
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.004
DNAL4 dynein, axonemal, light chain 4 -2.00085