CRCGN017_MCF10A.WT.HP_24H:J21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-acetylaminobiphenyl 11.17 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 4.91285
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.779
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.3075
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.7153
KIF20A kinesin family member 20A 2.59975
CCNA1 cyclin A1 2.5907
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 2.58035
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.5797
WIF1 WNT inhibitory factor 1 2.5376
AAMDC adipogenesis associated, Mth938 domain containing 2.4301
CXCR2 chemokine (C-X-C motif) receptor 2 2.37505
PKN1 protein kinase N1 2.30702
CEP63 centrosomal protein 63kDa 2.08295
CBR1 carbonyl reductase 1 2.0394
IGHMBP2 immunoglobulin mu binding protein 2 2.03748

decreased expression

Symbol Name Standardized Value
FASTKD5 FAST kinase domains 5 -9.49575
SLC35F2 solute carrier family 35, member F2 -5.1816
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.2079
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.53137
EIF5 eukaryotic translation initiation factor 5 -3.12389
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.9852
SMG8 SMG8 nonsense mediated mRNA decay factor -2.4839
THAP11 THAP domain containing 11 -2.4088
MAD2L1BP MAD2L1 binding protein -2.05465
TRIB3 tribbles pseudokinase 3 -2.05335