CRCGN017_MCF10A.WT.HP_24H:J23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pregnenolone 34.72 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

88 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 5.2224
SQOR sulfide quinone oxidoreductase 4.63545
ZNF586 zinc finger protein 586 4.2214
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.89905
ABHD6 abhydrolase domain containing 6 3.69798
ACAA1 acetyl-CoA acyltransferase 1 3.2204
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.924
ZNF134 zinc finger protein 134 2.7867
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.75455
OLFML2B olfactomedin-like 2B 2.65025
LYRM1 LYR motif containing 1 2.59335
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.55477
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.48362
CDPF1 cysteine-rich, DPF motif domain containing 1 2.4509
VWA1 von Willebrand factor A domain containing 1 2.42055
IFITM1 interferon induced transmembrane protein 1 2.36132
HBA1 hemoglobin, alpha 1 2.34195
ZFP36 ZFP36 ring finger protein 2.32505
MIA melanoma inhibitory activity 2.22525
FXYD5 FXYD domain containing ion transport regulator 5 2.16795
CDA cytidine deaminase 2.13225
UNC13D unc-13 homolog D (C. elegans) 2.1183
RGS2 regulator of G-protein signaling 2 2.1137
MFAP2 microfibrillar-associated protein 2 2.1136
FLNB filamin B, beta 2.11158
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 2.1086
GPX3 glutathione peroxidase 3 2.101
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.0986
URI1 URI1, prefoldin-like chaperone 2.09233
DACT1 dishevelled-binding antagonist of beta-catenin 1 2.08865
MAP2K5 mitogen-activated protein kinase kinase 5 2.0645
MGMT O-6-methylguanine-DNA methyltransferase 2.0622
EIF6 eukaryotic translation initiation factor 6 2.04915
NUTF2 nuclear transport factor 2 2.03655
WBP1L WW domain binding protein 1-like 2.03615
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.03525
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.0217
ZNF544 zinc finger protein 544 2.0187
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.0129
FN1 fibronectin 1 2.01269

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.20235
PCCB propionyl CoA carboxylase, beta polypeptide -5.0401
KIF14 kinesin family member 14 -5.01975
S100A8 S100 calcium binding protein A8 -4.91705
CYCS cytochrome c, somatic -4.83005
ARID4B AT rich interactive domain 4B (RBP1-like) -4.68055
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.60065
ACOT9 acyl-CoA thioesterase 9 -4.4789
TXNDC9 thioredoxin domain containing 9 -4.27413
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.17913
ANXA2 annexin A2 -4.09125
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.9982
GDF15 growth differentiation factor 15 -3.98255
COPS7A COP9 signalosome subunit 7A -3.6253
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.58368
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -3.09465
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.90918
TIMELESS timeless circadian clock -2.76965
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.7441
KCMF1 potassium channel modulatory factor 1 -2.70665
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -2.44445
UNC50 unc-50 homolog (C. elegans) -2.3502
MCM9 minichromosome maintenance complex component 9 -2.28335
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.25168
RNFT2 ring finger protein, transmembrane 2 -2.24393
CXCL14 chemokine (C-X-C motif) ligand 14 -2.2287
NCAPH non-SMC condensin I complex, subunit H -2.214
FBXO5 F-box protein 5 -2.1882
NEK4 NIMA-related kinase 4 -2.1728
KIF18A kinesin family member 18A -2.1641
NEK2 NIMA-related kinase 2 -2.15915
ARHGAP11A Rho GTPase activating protein 11A -2.1578
MRPL35 mitochondrial ribosomal protein L35 -2.1551
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.1423
IL12RB2 interleukin 12 receptor, beta 2 -2.14105
KNTC1 kinetochore associated 1 -2.1316
SMAP1 small ArfGAP 1 -2.13125
VBP1 von Hippel-Lindau binding protein 1 -2.11685
MPHOSPH9 M-phase phosphoprotein 9 -2.09153
IL19 interleukin 19 -2.09025
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.08495
ZBTB39 zinc finger and BTB domain containing 39 -2.0753
TRIM37 tripartite motif containing 37 -2.0726
CCDC47 coiled-coil domain containing 47 -2.0528
CA10 carbonic anhydrase X -2.04815
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -2.03695
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.0201
PLPPR4 phospholipid phosphatase related 4 -2.0199