CRCGN017_MCF10A.WT.HP_24H:J24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pregnenolone 11.57 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:J24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 4.66275
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.30665
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 3.8087
KLHL9 kelch-like family member 9 2.8844
OLFML2B olfactomedin-like 2B 2.826
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.7457
FYN FYN proto-oncogene, Src family tyrosine kinase 2.21727
AGR2 anterior gradient 2 2.1739
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.1616
CCDC85B coiled-coil domain containing 85B 2.0772
TICAM1 toll-like receptor adaptor molecule 1 2.0082
COMMD8 COMM domain containing 8 2.0033

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.7713
HAT1 histone acetyltransferase 1 -5.52465
CCDC86 coiled-coil domain containing 86 -4.6158
GDF15 growth differentiation factor 15 -4.48905
HMG20B high mobility group 20B -4.42035
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.1362
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.26605
IFRD2 interferon-related developmental regulator 2 -3.16315
HEATR1 HEAT repeat containing 1 -3.03988
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.7494
FOS FBJ murine osteosarcoma viral oncogene homolog -2.3604
VRK2 vaccinia related kinase 2 -2.09845
SPG11 spastic paraplegia 11 (autosomal recessive) -2.0808