CRCGN017_MCF10A.WT.HP_24H:K02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description edaravone 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDCA4 cell division cycle associated 4 5.07468
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.97482
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.66045
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.49467
C2CD2 C2 calcium-dependent domain containing 2 3.34821
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.14226
GRB10 growth factor receptor-bound protein 10 2.78147
METRN meteorin, glial cell differentiation regulator 2.75402
SOCS2 suppressor of cytokine signaling 2 2.2851
CHMP6 charged multivesicular body protein 6 2.28157
CCL2 chemokine (C-C motif) ligand 2 2.1548
PTPN9 protein tyrosine phosphatase, non-receptor type 9 2.00747

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.0
MRPS16 mitochondrial ribosomal protein S16 -4.77451
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -4.68965
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.65084
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.3185
NPDC1 neural proliferation, differentiation and control, 1 -3.10572
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.69829
LIN37 lin-37 DREAM MuvB core complex component -2.43063
AKTIP AKT interacting protein -2.39536
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -2.38999
BASP1 brain abundant, membrane attached signal protein 1 -2.37496
SEC24C SEC24 family member C -2.34089
MICU1 mitochondrial calcium uptake 1 -2.30224
TBCB tubulin folding cofactor B -2.25034
RPS5 ribosomal protein S5 -2.21518
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.1992
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.18987
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.15234
SETD6 SET domain containing 6 -2.10401
RUNDC3B RUN domain containing 3B -2.09324
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.06383
RPL18 ribosomal protein L18 -2.03447
GHITM growth hormone inducible transmembrane protein -2.01922