CRCGN017_MCF10A.WT.HP_24H:K03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description edaravone 11.14 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

105 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 5.23705
MAMLD1 mastermind-like domain containing 1 5.09822
COMP cartilage oligomeric matrix protein 4.96713
ZNF134 zinc finger protein 134 4.35931
ZNF551 zinc finger protein 551 4.10714
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.72765
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.47284
ZNF197 zinc finger protein 197 3.33194
GPATCH8 G patch domain containing 8 3.11103
ZNF211 zinc finger protein 211 2.80249
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.79785
TTC12 tetratricopeptide repeat domain 12 2.76715
GLB1L galactosidase, beta 1-like 2.71807
GGT5 gamma-glutamyltransferase 5 2.66294
ZNF195 zinc finger protein 195 2.61133
ZNF544 zinc finger protein 544 2.60046
ZNF587B zinc finger protein 587B 2.58274
ZNF606 zinc finger protein 606 2.55184
DCAF16 DDB1 and CUL4 associated factor 16 2.51858
ZNF813 zinc finger protein 813 2.50517
TIAM1 T-cell lymphoma invasion and metastasis 1 2.48333
PNPLA4 patatin-like phospholipase domain containing 4 2.47527
PRR15L proline rich 15-like 2.40982
HLA-DRA major histocompatibility complex, class II, DR alpha 2.39989
ZNF331 zinc finger protein 331 2.39559
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.36604
TRIM68 tripartite motif containing 68 2.36496
ZNF304 zinc finger protein 304 2.33669
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.32818
KRT81 keratin 81, type II 2.30051
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.27503
DCAF10 DDB1 and CUL4 associated factor 10 2.27429
ZNF350 zinc finger protein 350 2.26193
ZNF329 zinc finger protein 329 2.2506
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.24659
ZNF562 zinc finger protein 562 2.24392
ZNF671 zinc finger protein 671 2.23305
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.23014
TRAPPC2 trafficking protein particle complex 2 2.22697
FCHO1 FCH domain only 1 2.22308
FBXO11 F-box protein 11 2.20886
SMIM41 small integral membrane protein 41 2.19252
USB1 U6 snRNA biogenesis 1 2.16772
ZNF45 zinc finger protein 45 2.16726
GINS3 GINS complex subunit 3 (Psf3 homolog) 2.16074
PIMREG PICALM interacting mitotic regulator 2.15109
RNF2 ring finger protein 2 2.14463
DRC3 dynein regulatory complex subunit 3 2.14231
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.12654
MZF1 myeloid zinc finger 1 2.12386
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.11986
FBLN5 fibulin 5 2.11674
EPS8L2 EPS8-like 2 2.11431
TUBB4A tubulin, beta 4A class IVa 2.10652
NELL2 NEL-like 2 (chicken) 2.09989
HAUS6 HAUS augmin-like complex, subunit 6 2.0908
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 2.0706
MNS1 meiosis-specific nuclear structural 1 2.06922
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.06228
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.06122
HAPLN2 hyaluronan and proteoglycan link protein 2 2.0597
EVI2B ecotropic viral integration site 2B 2.05732
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.05228
CORO1A coronin, actin binding protein, 1A 2.05057
SPA17 sperm autoantigenic protein 17 2.03734
PDF peptide deformylase (mitochondrial) 2.03183
EVI2A ecotropic viral integration site 2A 2.03141
ZNF426 zinc finger protein 426 2.01717
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.0046

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -9.87952
TNIP1 TNFAIP3 interacting protein 1 -5.21448
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -4.8229
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -4.81661
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.40708
TUBB6 tubulin, beta 6 class V -4.2605
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.53467
HMOX2 heme oxygenase 2 -2.83654
GDF15 growth differentiation factor 15 -2.72762
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.71297
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.66764
TASOR2 transcription activation suppressor family member 2 -2.66457
EXOSC4 exosome component 4 -2.48171
MAP2K1 mitogen-activated protein kinase kinase 1 -2.47956
CPPED1 calcineurin-like phosphoesterase domain containing 1 -2.46224
MTERF3 mitochondrial transcription termination factor 3 -2.44048
SDF4 stromal cell derived factor 4 -2.40126
UBN1 ubinuclein 1 -2.35974
PEX3 peroxisomal biogenesis factor 3 -2.35862
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.30423
MSMO1 methylsterol monooxygenase 1 -2.24118
HEXB hexosaminidase B (beta polypeptide) -2.23796
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.22491
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.16333
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.16135
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.14803
FAM216A family with sequence similarity 216, member A -2.12586
TM2D1 TM2 domain containing 1 -2.1198
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.10618
TRIM25 tripartite motif containing 25 -2.09456
DEXI Dexi homolog (mouse) -2.08591
S100A8 S100 calcium binding protein A8 -2.06936
LRRC17 leucine rich repeat containing 17 -2.02801
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.01185
HLA-G major histocompatibility complex, class I, G -2.0048
GADD45G growth arrest and DNA-damage-inducible, gamma -2.00365