CRCGN017_MCF10A.WT.HP_24H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 3.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

288 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEF2C myocyte enhancer factor 2C 4.28153
TBX2 T-box 2 4.10335
LOXL1 lysyl oxidase-like 1 4.03145
ABHD6 abhydrolase domain containing 6 3.94568
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 3.89233
SYNE2 spectrin repeat containing, nuclear envelope 2 3.8635
CNRIP1 cannabinoid receptor interacting protein 1 3.84895
MOK MOK protein kinase 3.77305
NOP53 NOP53 ribosome biogenesis factor 3.5465
PPARG peroxisome proliferator-activated receptor gamma 3.49655
GHR growth hormone receptor 3.49455
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.38675
GRAMD4 GRAM domain containing 4 3.33105
ACLY ATP citrate lyase 3.31332
GRB10 growth factor receptor-bound protein 10 3.27027
LETMD1 LETM1 domain containing 1 3.26825
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.2327
FAT1 FAT atypical cadherin 1 3.1049
GLB1L2 galactosidase, beta 1-like 2 3.0791
PGLS 6-phosphogluconolactonase 3.06743
USP6NL USP6 N-terminal like 2.983
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.9236
TCTN1 tectonic family member 1 2.8898
TPPP3 tubulin polymerization-promoting protein family member 3 2.8819
DENND2D DENN/MADD domain containing 2D 2.86555
EIF2D eukaryotic translation initiation factor 2D 2.8044
R3HDM2 R3H domain containing 2 2.78775
RLIM ring finger protein, LIM domain interacting 2.74855
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.7374
KLF4 Kruppel-like factor 4 (gut) 2.70442
GAA glucosidase, alpha; acid 2.69695
PYCARD PYD and CARD domain containing 2.6731
WLS wntless Wnt ligand secretion mediator 2.64555
DOCK1 dedicator of cytokinesis 1 2.60255
DDTL D-dopachrome tautomerase-like 2.5863
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.5726
RASL11B RAS-like, family 11, member B 2.5718
ANXA4 annexin A4 2.57023
CPZ carboxypeptidase Z 2.54995
PLA1A phospholipase A1 member A 2.54515
RNF44 ring finger protein 44 2.53455
EML3 echinoderm microtubule associated protein like 3 2.53345
FHL2 four and a half LIM domains 2 2.49295
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 2.4919
CAPN9 calpain 9 2.48855
LSR lipolysis stimulated lipoprotein receptor 2.47735
TMEM53 transmembrane protein 53 2.43525
COA7 cytochrome c oxidase assembly factor 7 (putative) 2.4209
FCHO1 FCH domain only 1 2.41355
H2BC12 H2B clustered histone 12 2.41232
EIF3L eukaryotic translation initiation factor 3, subunit L 2.4102
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.39845
PLD3 phospholipase D family, member 3 2.377
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.37375
YBX1 Y box binding protein 1 2.34627
TRAPPC6A trafficking protein particle complex 6A 2.3407
METRN meteorin, glial cell differentiation regulator 2.32825
CPNE7 copine VII 2.32385
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 2.31692
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.31385
TMEM51 transmembrane protein 51 2.30305
CRYBG1 crystallin beta-gamma domain containing 1 2.30275
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.29945
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.2841
DCAF4 DDB1 and CUL4 associated factor 4 2.27265
NPC2 Niemann-Pick disease, type C2 2.26605
BLCAP bladder cancer associated protein 2.2592
DRC4 dynein regulatory complex subunit 4 2.25235
SIPA1L3 signal-induced proliferation-associated 1 like 3 2.24615
LMO2 LIM domain only 2 (rhombotin-like 1) 2.2336
MSRA methionine sulfoxide reductase A 2.1987
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 2.19405
RAP1GAP RAP1 GTPase activating protein 2.18125
ERMP1 endoplasmic reticulum metallopeptidase 1 2.17915
BBLN bublin coiled coil protein 2.17717
GRN granulin 2.17377
NCF1 neutrophil cytosolic factor 1 2.1558
LZTR1 leucine-zipper-like transcription regulator 1 2.15325
LGALS9C lectin, galactoside-binding, soluble, 9C 2.1465
GPR153 G protein-coupled receptor 153 2.145
CCDC81 coiled-coil domain containing 81 2.1355
CUTA cutA divalent cation tolerance homolog (E. coli) 2.1242
TSPAN4 tetraspanin 4 2.1224
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 2.11678
ATP10D ATPase, class V, type 10D 2.1136
ELL3 elongation factor RNA polymerase II-like 3 2.11077
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 2.09849
BLNK B-cell linker 2.09635
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.0893
SH2B2 SH2B adaptor protein 2 2.0878
CDC45 cell division cycle 45 2.0855
PABPC3 poly(A) binding protein, cytoplasmic 3 2.0816
SQOR sulfide quinone oxidoreductase 2.07855
IRF2BP1 interferon regulatory factor 2 binding protein 1 2.07605
DSG2 desmoglein 2 2.07505
PTK2B protein tyrosine kinase 2 beta 2.0713
SPATA2L spermatogenesis associated 2-like 2.06885
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.05975
FYN FYN proto-oncogene, Src family tyrosine kinase 2.04925
MRNIP MRN complex interacting protein 2.04875
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.04215
PHKA2 phosphorylase kinase, alpha 2 (liver) 2.03877
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 2.0361
FAM3C family with sequence similarity 3, member C 2.034
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.01685
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.01608
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 2.00605
KRT2 keratin 2, type II 2.00175

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -9.6051
PLK1 polo-like kinase 1 -8.55005
UBE2C ubiquitin-conjugating enzyme E2C -7.02815
CCNB2 cyclin B2 -6.53575
KIF20A kinesin family member 20A -6.51795
PSRC1 proline/serine-rich coiled-coil 1 -6.09625
PCCB propionyl CoA carboxylase, beta polypeptide -5.6291
TOP2A topoisomerase (DNA) II alpha 170kDa -5.46898
CCNB1 cyclin B1 -5.1805
CCNA2 cyclin A2 -5.0869
KIF14 kinesin family member 14 -4.8977
ARID4B AT rich interactive domain 4B (RBP1-like) -4.54095
BIRC5 baculoviral IAP repeat containing 5 -4.38113
DEPDC1 DEP domain containing 1 -4.3751
AURKB aurora kinase B -4.28745
CDK1 cyclin-dependent kinase 1 -4.22228
CDCA3 cell division cycle associated 3 -4.16925
MT2A metallothionein 2A -4.13205
SNX7 sorting nexin 7 -4.12195
NEK2 NIMA-related kinase 2 -4.10318
NUSAP1 nucleolar and spindle associated protein 1 -3.87778
GOLT1B golgi transport 1B -3.67845
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.677
GDF15 growth differentiation factor 15 -3.6598
CENPA centromere protein A -3.63622
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -3.61655
TROAP trophinin associated protein -3.60415
CDCA8 cell division cycle associated 8 -3.4832
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.4806
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.4749
SPAG5 sperm associated antigen 5 -3.4681
GTF2A2 general transcription factor IIA, 2, 12kDa -3.3988
CBR3 carbonyl reductase 3 -3.3869
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.37995
KIF4A kinesin family member 4A -3.34285
IFRD2 interferon-related developmental regulator 2 -3.32425
HJURP Holliday junction recognition protein -3.2968
FOXM1 forkhead box M1 -3.29305
TPX2 TPX2, microtubule-associated -3.2692
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.26905
LBR lamin B receptor -3.2493
SPDL1 spindle apparatus coiled-coil protein 1 -3.2449
CDC25C cell division cycle 25C -3.23003
ASF1B anti-silencing function 1B histone chaperone -3.2267
PBK PDZ binding kinase -3.1733
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -3.1178
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.11685
GPR88 G protein-coupled receptor 88 -3.11325
OXSR1 oxidative stress responsive 1 -3.0959
MSN moesin -3.0951
KIF22 kinesin family member 22 -3.0869
CEP55 centrosomal protein 55kDa -3.07605
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.07195
NLRP2B NLR family pyrin domain containing 2B -3.06705
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -3.06234
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -3.0498
KIF18A kinesin family member 18A -3.04075
AURKA aurora kinase A -3.01463
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.9928
OIP5 Opa interacting protein 5 -2.97795
SPC25 SPC25, NDC80 kinetochore complex component -2.96695
NDC80 NDC80 kinetochore complex component -2.92315
KIF11 kinesin family member 11 -2.8648
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -2.8394
NCAPH non-SMC condensin I complex, subunit H -2.82485
PREB prolactin regulatory element binding -2.82415
PARPBP PARP1 binding protein -2.78835
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.7696
CREB1 cAMP responsive element binding protein 1 -2.76184
NCAPG2 non-SMC condensin II complex, subunit G2 -2.755
APEH acylaminoacyl-peptide hydrolase -2.7351
TACC3 transforming, acidic coiled-coil containing protein 3 -2.7301
ECD ecdysoneless homolog (Drosophila) -2.67685
PRC1 protein regulator of cytokinesis 1 -2.65785
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.65605
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.63585
FER fer (fps/fes related) tyrosine kinase -2.6346
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.61767
KIF23 kinesin family member 23 -2.6175
TOMM34 translocase of outer mitochondrial membrane 34 -2.6123
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.59645
SKA1 spindle and kinetochore associated complex subunit 1 -2.588
CENPN centromere protein N -2.57673
BORA bora, aurora kinase A activator -2.55095
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -2.54145
MKI67 marker of proliferation Ki-67 -2.51291
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.51085
GIN1 gypsy retrotransposon integrase 1 -2.48115
TTK TTK protein kinase -2.48105
SHCBP1 SHC SH2-domain binding protein 1 -2.47945
ZBTB6 zinc finger and BTB domain containing 6 -2.4786
UBP1 upstream binding protein 1 (LBP-1a) -2.46315
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -2.4621
ZNF143 zinc finger protein 143 -2.4615
BLTP3B bridge-like lipid transfer protein family member 3B -2.43715
MIS12 MIS12 kinetochore complex component -2.43615
SLC35B1 solute carrier family 35, member B1 -2.4343
TK1 thymidine kinase 1, soluble -2.425
CDKN3 cyclin-dependent kinase inhibitor 3 -2.42365
NCAPD2 non-SMC condensin I complex, subunit D2 -2.4209
CALU calumenin -2.41241
VBP1 von Hippel-Lindau binding protein 1 -2.4065
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.402
CCNF cyclin F -2.38235
TICAM1 toll-like receptor adaptor molecule 1 -2.37575
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.3747
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.3634
CETN3 centrin, EF-hand protein, 3 -2.35915
MT1X metallothionein 1X -2.35593
ANKRD10 ankyrin repeat domain 10 -2.3495
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.32645
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.3251
PIMREG PICALM interacting mitotic regulator -2.3077
ZNF200 zinc finger protein 200 -2.30585
HROB homologous recombination factor with OB-fold -2.2945
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.2909
BBS7 Bardet-Biedl syndrome 7 -2.28315
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -2.26478
BARD1 BRCA1 associated RING domain 1 -2.25685
MAP2K4 mitogen-activated protein kinase kinase 4 -2.25392
HAT1 histone acetyltransferase 1 -2.23055
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.2284
NR1D2 nuclear receptor subfamily 1, group D, member 2 -2.2225
AFF4 AF4/FMR2 family, member 4 -2.21955
MBIP MAP3K12 binding inhibitory protein 1 -2.2139
AZIN2 antizyme inhibitor 2 -2.21275
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.20815
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.20815
ELL2 elongation factor, RNA polymerase II, 2 -2.20665
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 -2.20292
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.20245
KIF18B kinesin family member 18B -2.19615
RNASE7 ribonuclease, RNase A family, 7 -2.19523
PALS1 protein associated with LIN7 1, MAGUK p55 family member -2.1941
NUP93 nucleoporin 93kDa -2.19195
STMN1 stathmin 1 -2.18275
SNRPN small nuclear ribonucleoprotein polypeptide N -2.1778
UBL5 ubiquitin-like 5 -2.16405
TMEM115 transmembrane protein 115 -2.1601
CEP76 centrosomal protein 76kDa -2.15712
CENPC centromere protein C -2.15405
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -2.152
NCKIPSD NCK interacting protein with SH3 domain -2.15055
TUBGCP4 tubulin, gamma complex associated protein 4 -2.14655
GEMIN2 gem (nuclear organelle) associated protein 2 -2.14139
KIF1B kinesin family member 1B -2.13635
CKAP2 cytoskeleton associated protein 2 -2.12385
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.11475
PNPO pyridoxamine 5'-phosphate oxidase -2.11225
SLIT2 slit homolog 2 (Drosophila) -2.1122
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.0956
LINS1 lines homolog 1 -2.09505
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.09135
USP39 ubiquitin specific peptidase 39 -2.0873
ZMYM1 zinc finger, MYM-type 1 -2.08565
MANEA mannosidase, endo-alpha -2.0827
TUBG1 tubulin, gamma 1 -2.07865
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.0779
FBXO3 F-box protein 3 -2.0765
XPO7 exportin 7 -2.076
RAD51C RAD51 paralog C -2.07232
HSF2 heat shock transcription factor 2 -2.06925
ARF4 ADP-ribosylation factor 4 -2.0658
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.0658
AARS1 alanyl-tRNA synthetase 1 -2.06515
MCTS1 malignant T cell amplified sequence 1 -2.05785
AK6 adenylate kinase 6 -2.0563
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.0546
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -2.0528
EDC3 enhancer of mRNA decapping 3 -2.0484
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -2.04135
KDM7A lysine (K)-specific demethylase 7A -2.0335
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.032
TMEM214 transmembrane protein 214 -2.02315
EMSY EMSY transcriptional repressor, BRCA2 interacting -2.01995
PTPRG protein tyrosine phosphatase, receptor type, G -2.01725
FRS2 fibroblast growth factor receptor substrate 2 -2.0088
PRKACB protein kinase, cAMP-dependent, catalytic, beta -2.0056
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -2.00355
DONSON downstream neighbor of SON -2.0017