CRCGN017_MCF10A.WT.HP_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

158 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.51205
STIMATE STIM activating enhancer 6.1352
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 5.2009
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.0767
SPAG4 sperm associated antigen 4 4.803
WIF1 WNT inhibitory factor 1 4.69935
TCTN1 tectonic family member 1 3.99755
AGR2 anterior gradient 2 3.58025
CNRIP1 cannabinoid receptor interacting protein 1 3.37945
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.32932
STK25 serine/threonine kinase 25 2.92845
PGAP2 post-GPI attachment to proteins 2 2.83568
EML3 echinoderm microtubule associated protein like 3 2.73843
CCDC85B coiled-coil domain containing 85B 2.6748
TMEM161A transmembrane protein 161A 2.6213
HBB hemoglobin, beta 2.6194
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.54455
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 2.53655
CDC45 cell division cycle 45 2.5303
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.5274
CCDC81 coiled-coil domain containing 81 2.5239
NBEAL2 neurobeachin-like 2 2.5173
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.48885
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.43675
AHCY adenosylhomocysteinase 2.413
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.4027
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.3912
BLCAP bladder cancer associated protein 2.3748
HBA1 hemoglobin, alpha 1 2.34982
FCHO1 FCH domain only 1 2.34615
TSPAN4 tetraspanin 4 2.3458
ADRB2 adrenoceptor beta 2, surface 2.3091
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.27592
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.273
ENGASE endo-beta-N-acetylglucosaminidase 2.25865
LCAT lecithin-cholesterol acyltransferase 2.2552
PSKH1 protein serine kinase H1 2.201
GTPBP8 GTP-binding protein 8 (putative) 2.1978
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.1974
ICMT isoprenylcysteine carboxyl methyltransferase 2.17928
PLA2G4B phospholipase A2, group IVB (cytosolic) 2.17728
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.16895
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.1687
MXD3 MAX dimerization protein 3 2.1576
GLI3 GLI family zinc finger 3 2.1541
EPHB3 EPH receptor B3 2.1527
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.15115
FNDC3B fibronectin type III domain containing 3B 2.1456
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.14395
YPEL1 yippee-like 1 (Drosophila) 2.1329
BBLN bublin coiled coil protein 2.11888
ABHD4 abhydrolase domain containing 4 2.1106
KANK1 KN motif and ankyrin repeat domains 1 2.1088
GHR growth hormone receptor 2.09485
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.0816
MED24 mediator complex subunit 24 2.07855
PTK2B protein tyrosine kinase 2 beta 2.0785
LZTR1 leucine-zipper-like transcription regulator 1 2.07835
MCM6 minichromosome maintenance complex component 6 2.0749
INTS11 integrator complex subunit 11 2.07475
DVL3 dishevelled segment polarity protein 3 2.06205
WAS Wiskott-Aldrich syndrome 2.06187
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.05857
LAMA5 laminin, alpha 5 2.0544
FZD7 frizzled class receptor 7 2.03865
PADI1 peptidyl arginine deiminase, type I 2.03715
TBX21 T-box 21 2.03705
QARS1 glutaminyl-tRNA synthetase 1 2.0298
TSPOAP1 TSPO associated protein 1 2.02875
ZNF692 zinc finger protein 692 2.02815
SCAP SREBF chaperone 2.027
PDLIM1 PDZ and LIM domain 1 2.02675
NPIPB5 nuclear pore complex interacting protein family, member B5 2.0003

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.71125
TM9SF3 transmembrane 9 superfamily member 3 -5.37505
GDF15 growth differentiation factor 15 -5.32455
NGRN neugrin, neurite outgrowth associated -4.418
PCCB propionyl CoA carboxylase, beta polypeptide -4.29935
ETFB electron-transfer-flavoprotein, beta polypeptide -4.1677
CCNB2 cyclin B2 -3.917
TRIB3 tribbles pseudokinase 3 -3.87595
NPDC1 neural proliferation, differentiation and control, 1 -3.7726
CDC20 cell division cycle 20 -3.7269
GOLT1B golgi transport 1B -3.6527
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.4374
MT2A metallothionein 2A -3.3696
NT5DC2 5'-nucleotidase domain containing 2 -3.0262
KRT14 keratin 14, type I -2.9755
ANKRD10 ankyrin repeat domain 10 -2.92545
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.92325
CDK7 cyclin-dependent kinase 7 -2.8926
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.84645
CAB39 calcium binding protein 39 -2.8168
AARS1 alanyl-tRNA synthetase 1 -2.79575
GIN1 gypsy retrotransposon integrase 1 -2.7859
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.7797
ARHGAP12 Rho GTPase activating protein 12 -2.77705
CGRRF1 cell growth regulator with ring finger domain 1 -2.7755
CA2 carbonic anhydrase II -2.7746
NLRP2B NLR family pyrin domain containing 2B -2.75515
CCNB1 cyclin B1 -2.68815
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.6809
PSRC1 proline/serine-rich coiled-coil 1 -2.67925
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.638
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.62115
WASHC4 WASH complex subunit 4 -2.6032
MAD2L1BP MAD2L1 binding protein -2.57335
CLDND1 claudin domain containing 1 -2.5653
SEC24B SEC24 family member B -2.52795
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.4792
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.4711
MTFR1 mitochondrial fission regulator 1 -2.45843
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.4314
INTS12 integrator complex subunit 12 -2.41655
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.40245
ANXA7 annexin A7 -2.3995
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.39908
MED28 mediator complex subunit 28 -2.3948
GTF2A2 general transcription factor IIA, 2, 12kDa -2.3712
ASF1A anti-silencing function 1A histone chaperone -2.3527
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.32985
TM2D3 TM2 domain containing 3 -2.32695
AURKA aurora kinase A -2.32243
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -2.3203
ADI1 acireductone dioxygenase 1 -2.31515
FNDC3A fibronectin type III domain containing 3A -2.30868
MCTS1 malignant T cell amplified sequence 1 -2.27875
PRKACB protein kinase, cAMP-dependent, catalytic, beta -2.25985
CLK3 CDC-like kinase 3 -2.24605
KIF20A kinesin family member 20A -2.23435
UNC50 unc-50 homolog (C. elegans) -2.2259
RPL39L ribosomal protein L39-like -2.1976
GOLT1A golgi transport 1A -2.18975
GMFG glia maturation factor, gamma -2.1877
RNF4 ring finger protein 4 -2.1786
LIG4 ligase IV, DNA, ATP-dependent -2.15735
PDE8A phosphodiesterase 8A -2.15613
SLC25A46 solute carrier family 25, member 46 -2.14855
GOLM1 golgi membrane protein 1 -2.13005
CYTH2 cytohesin 2 -2.12935
PRC1 protein regulator of cytokinesis 1 -2.1253
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -2.12245
RNF111 ring finger protein 111 -2.1089
ZFYVE16 zinc finger, FYVE domain containing 16 -2.0967
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.09475
TTI2 TELO2 interacting protein 2 -2.09415
SLC35F2 solute carrier family 35, member F2 -2.093
KCTD9 potassium channel tetramerization domain containing 9 -2.0873
AK6 adenylate kinase 6 -2.0828
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.0785
MARCHF5 membrane associated ring-CH-type finger 5 -2.0774
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -2.0684
SAR1B secretion associated, Ras related GTPase 1B -2.0674
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.06555
DCTN4 dynactin 4 (p62) -2.06445
TSG101 tumor susceptibility 101 -2.0187
VBP1 von Hippel-Lindau binding protein 1 -2.0175
PEX19 peroxisomal biogenesis factor 19 -2.0037