CRCGN017_MCF10A.WT.HP_24H:K14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrylamide 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.33725
LAGE3 L antigen family, member 3 5.31965
STIMATE STIM activating enhancer 4.7086
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.317
SLC10A3 solute carrier family 10, member 3 3.6119
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 3.48743
BZW2 basic leucine zipper and W2 domains 2 3.3738
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.1455
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.9057
FAM3A family with sequence similarity 3, member A 2.86818
FAM50A family with sequence similarity 50, member A 2.6745
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.5895
VBP1 von Hippel-Lindau binding protein 1 2.5534
FBXO7 F-box protein 7 2.41335
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 2.3646
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.3574
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.297
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.22657
DKC1 dyskeratosis congenita 1, dyskerin 2.1954
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.09739
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 2.05048
NONO non-POU domain containing, octamer-binding 2.02415
EMD emerin 2.02205

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.15475
DSG2 desmoglein 2 -4.69895
CAB39 calcium binding protein 39 -4.47595
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.42785
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.41405
CD44 CD44 molecule (Indian blood group) -4.09947
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.99825
PHKA1 phosphorylase kinase, alpha 1 (muscle) -3.73255
KIF20A kinesin family member 20A -3.57795
HMG20B high mobility group 20B -3.30403
RPS5 ribosomal protein S5 -3.19695
S100A8 S100 calcium binding protein A8 -3.1701
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.84788
PFN1 profilin 1 -2.79845
MT2A metallothionein 2A -2.68425
CXCL6 chemokine (C-X-C motif) ligand 6 -2.67665
TMEM267 transmembrane protein 267 -2.60985
SCAND1 SCAN domain containing 1 -2.46925
KIF3B kinesin family member 3B -2.3888
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.3743
FAM169A family with sequence similarity 169, member A -2.3738
FBXO3 F-box protein 3 -2.3636
RBBP5 retinoblastoma binding protein 5 -2.3194
ACAA1 acetyl-CoA acyltransferase 1 -2.31868
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -2.30865
LIPG lipase, endothelial -2.22
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -2.21385
NME6 NME/NM23 nucleoside diphosphate kinase 6 -2.1689
PAIP1 poly(A) binding protein interacting protein 1 -2.14888
CTNNA2 catenin (cadherin-associated protein), alpha 2 -2.07345
DROSHA drosha, ribonuclease type III -2.07265
ATG7 autophagy related 7 -2.07095
CCL16 chemokine (C-C motif) ligand 16 -2.06595
TTC33 tetratricopeptide repeat domain 33 -2.0625
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 -2.05987
LZTFL1 leucine zipper transcription factor-like 1 -2.04995
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.048
PSRC1 proline/serine-rich coiled-coil 1 -2.0014