CRCGN017_MCF10A.WT.HP_24H:K16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminoanthracene 101.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

347 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 6.007
PROS1 protein S (alpha) 5.29685
TATDN2 TatD DNase domain containing 2 5.25
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.1628
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.06495
ABHD4 abhydrolase domain containing 4 5.0233
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.8818
ZW10 zw10 kinetochore protein 4.69615
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 4.5129
CCDC92 coiled-coil domain containing 92 4.3573
LYN LYN proto-oncogene, Src family tyrosine kinase 4.03948
WIF1 WNT inhibitory factor 1 3.76045
PTK2B protein tyrosine kinase 2 beta 3.51533
RAB31 RAB31, member RAS oncogene family 3.39347
UGDH UDP-glucose 6-dehydrogenase 3.34815
STXBP1 syntaxin binding protein 1 3.0185
SETD5 SET domain containing 5 2.88915
SFXN3 sideroflexin 3 2.8275
CBX6 chromobox homolog 6 2.7912
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.7547
ZNF189 zinc finger protein 189 2.74005
UBE4A ubiquitination factor E4A 2.7258
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.65196
EMC3 ER membrane protein complex subunit 3 2.5947
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.589
MICA MHC class I polypeptide-related sequence A 2.57342
DENND2D DENN/MADD domain containing 2D 2.5596
CST3 cystatin C 2.48845
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 2.48785
OCEL1 occludin/ELL domain containing 1 2.4813
CTNNBL1 catenin, beta like 1 2.46575
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.46495
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 2.4619
KCTD5 potassium channel tetramerization domain containing 5 2.44605
ARCN1 archain 1 2.44475
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 2.4363
EMP3 epithelial membrane protein 3 2.42705
ZNF761 zinc finger protein 761 2.41435
S100A10 S100 calcium binding protein A10 2.4076
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 2.407
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 2.39955
PARL presenilin associated, rhomboid-like 2.39055
MIDEAS mitotic deacetylase associated SANT domain protein 2.37895
MKRN2 makorin ring finger protein 2 2.36925
SREBF2 sterol regulatory element binding transcription factor 2 2.36448
SETD1B SET domain containing 1B 2.35875
TMBIM6 transmembrane BAX inhibitor motif containing 6 2.35575
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2.355
RNF220 ring finger protein 220 2.3455
KIAA0513 KIAA0513 2.345
THYN1 thymocyte nuclear protein 1 2.341
PLS1 plastin 1 2.34
ZNF384 zinc finger protein 384 2.3218
IGFBP6 insulin-like growth factor binding protein 6 2.31885
DOLK dolichol kinase 2.2872
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 2.274
TOR1AIP2 torsin A interacting protein 2 2.27325
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.2658
ESRP2 epithelial splicing regulatory protein 2 2.2639
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.25495
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.2381
TRAPPC4 trafficking protein particle complex 4 2.23422
HDAC7 histone deacetylase 7 2.22675
TPD52L2 tumor protein D52-like 2 2.21945
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) 2.2045
DCPS decapping enzyme, scavenger 2.19045
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.1886
CCDC85C coiled-coil domain containing 85C 2.18315
CERS2 ceramide synthase 2 2.1714
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.16395
NUP210 nucleoporin 210kDa 2.15567
WSB2 WD repeat and SOCS box containing 2 2.151
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 2.15015
ANXA5 annexin A5 2.14695
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.1405
APLP2 amyloid beta (A4) precursor-like protein 2 2.12745
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 2.1268
KLC1 kinesin light chain 1 2.12028
TBC1D13 TBC1 domain family, member 13 2.11133
CKB creatine kinase, brain 2.1052
F2R coagulation factor II (thrombin) receptor 2.0982
TUSC2 tumor suppressor candidate 2 2.08835
RPL34 ribosomal protein L34 2.08635
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2.0863
ARF5 ADP-ribosylation factor 5 2.0768
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.07085
ANG angiogenin, ribonuclease, RNase A family, 5 2.06755
SNX10 sorting nexin 10 2.06595
CCL2 chemokine (C-C motif) ligand 2 2.06115
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.04745
AGPS alkylglycerone phosphate synthase 2.0337
UQCRC1 ubiquinol-cytochrome c reductase core protein I 2.0292
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 2.02785
KRI1 KRI1 homolog (S. cerevisiae) 2.01395
LOC124906748 beta-defensin 4A 2.01155
SHTN1 shootin 1 2.0073

decreased expression

Symbol Name Standardized Value
LYPLA1 lysophospholipase I -7.53363
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.56605
CCDC86 coiled-coil domain containing 86 -5.17035
TNIP1 TNFAIP3 interacting protein 1 -5.11735
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.0
YME1L1 YME1-like 1 ATPase -4.93485
PCNA proliferating cell nuclear antigen -4.66275
PUF60 poly-U binding splicing factor 60KDa -4.65935
JMJD6 jumonji domain containing 6 -4.42812
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.31768
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.31055
MRPL15 mitochondrial ribosomal protein L15 -4.29835
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.0618
KRT14 keratin 14, type I -3.76535
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -3.61355
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.5122
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -3.5013
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) -3.451
CD53 CD53 molecule -3.44095
SLC35B1 solute carrier family 35, member B1 -3.26725
MIS18BP1 MIS18 binding protein 1 -3.17955
ALOX5AP arachidonate 5-lipoxygenase-activating protein -3.1497
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -3.07975
FKBP1C FK506 binding protein 1C -3.0433
RHOH ras homolog family member H -3.0309
NXT1 nuclear transport factor 2-like export factor 1 -3.02045
XPO7 exportin 7 -2.99155
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.9381
CTNND1 catenin (cadherin-associated protein), delta 1 -2.9134
PLVAP plasmalemma vesicle associated protein -2.8647
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.8603
PARD3 par-3 family cell polarity regulator -2.80346
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.79935
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.79385
IL2RA interleukin 2 receptor, alpha -2.78625
NLRP4 NLR family, pyrin domain containing 4 -2.75355
HMHB1 histocompatibility (minor) HB-1 -2.74665
N4BP3 NEDD4 binding protein 3 -2.73025
SNX5 sorting nexin 5 -2.7075
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -2.69937
CD207 CD207 molecule, langerin -2.69735
MAK16 MAK16 homolog (S. cerevisiae) -2.6773
PYCARD PYD and CARD domain containing -2.67465
GML glycosylphosphatidylinositol anchored molecule like -2.6634
UBE2W ubiquitin-conjugating enzyme E2W (putative) -2.6632
MYF5 myogenic factor 5 -2.6604
PLXNC1 plexin C1 -2.64557
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.6335
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 -2.63055
RAPSN receptor-associated protein of the synapse -2.6299
WASHC4 WASH complex subunit 4 -2.62287
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -2.616
BANK1 B-cell scaffold protein with ankyrin repeats 1 -2.58285
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -2.5749
FOXI1 forkhead box I1 -2.57135
IL11RA interleukin 11 receptor, alpha -2.56215
PRPF18 pre-mRNA processing factor 18 -2.5594
LPAR4 lysophosphatidic acid receptor 4 -2.5523
SLC30A1 solute carrier family 30 (zinc transporter), member 1 -2.5521
ANKRD26 ankyrin repeat domain 26 -2.54435
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.53795
ZNF26 zinc finger protein 26 -2.5378
USP2 ubiquitin specific peptidase 2 -2.5257
CCN6 cellular communication network factor 6 -2.51425
FHIT fragile histidine triad -2.5139
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 -2.50697
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -2.4999
FRAS1 Fraser extracellular matrix complex subunit 1 -2.49395
TENM4 teneurin transmembrane protein 4 -2.4939
HOXB2 homeobox B2 -2.4912
ZNF124 zinc finger protein 124 -2.47785
CD86 CD86 molecule -2.46478
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 -2.46302
SLC38A10 solute carrier family 38, member 10 -2.46295
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -2.46112
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.4585
DAZ2 deleted in azoospermia 2 -2.45428
NTNG2 netrin G2 -2.4447
SPTA1 spectrin, alpha, erythrocytic 1 -2.43985
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.43925
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.437
NSFL1C NSFL1 (p97) cofactor (p47) -2.43238
AUTS2 autism susceptibility candidate 2 -2.42075
TGDS TDP-glucose 4,6-dehydratase -2.41925
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 -2.417
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.41208
STK17B serine/threonine kinase 17b -2.4049
TNNI2 troponin I type 2 (skeletal, fast) -2.40285
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -2.4027
CD22 CD22 molecule -2.4021
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -2.39985
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -2.3988
MRPL9 mitochondrial ribosomal protein L9 -2.39665
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.39585
GRM6 glutamate receptor, metabotropic 6 -2.38845
MINDY3 MINDY lysine 48 deubiquitinase 3 -2.3869
TSHB thyroid stimulating hormone, beta -2.3858
TENT4A terminal nucleotidyltransferase 4A -2.3765
DRC11 dynein regulatory complex subunit 11 -2.3727
SYNPO2L synaptopodin 2-like -2.369
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit -2.35515
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.3531
IFNA7 interferon, alpha 7 -2.343
PPID peptidylprolyl isomerase D -2.3342
CLEC4E C-type lectin domain family 4, member E -2.32605
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.31768
ZNF34 zinc finger protein 34 -2.3176
DCAF13 DDB1 and CUL4 associated factor 13 -2.3168
CYTIP cytohesin 1 interacting protein -2.31195
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 -2.30665
NLK nemo-like kinase -2.3038
ZNF334 zinc finger protein 334 -2.3019
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal -2.2976
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -2.2936
TASOR2 transcription activation suppressor family member 2 -2.2891
PANK2 pantothenate kinase 2 -2.28765
BFAR bifunctional apoptosis regulator -2.286
KIF16B kinesin family member 16B -2.28325
APMAP adipocyte plasma membrane associated protein -2.27695
CCR6 chemokine (C-C motif) receptor 6 -2.27415
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -2.271
NES nestin -2.27085
DEPTOR DEP domain containing MTOR-interacting protein -2.2682
AIG1 androgen-induced 1 -2.2636
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 -2.2551
BFSP2 beaded filament structural protein 2, phakinin -2.24695
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -2.23872
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.2386
EYA3 EYA transcriptional coactivator and phosphatase 3 -2.2342
TREM2 triggering receptor expressed on myeloid cells 2 -2.2328
CHIT1 chitinase 1 (chitotriosidase) -2.23085
DZANK1 double zinc ribbon and ankyrin repeat domains 1 -2.22045
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -2.22005
TLCD3A TLC domain containing 3A -2.2192
MTMR7 myotubularin related protein 7 -2.2186
HID1 HID1 domain containing -2.21018
HCRT hypocretin (orexin) neuropeptide precursor -2.209
PRAMEF12 PRAME family member 12 -2.2074
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.20665
WDR45B WD repeat domain 45B -2.2042
FOCAD focadhesin -2.20295
NUP153 nucleoporin 153kDa -2.2025
KIN Kin17 DNA and RNA binding protein -2.19585
NOL10 nucleolar protein 10 -2.19145
ZNF107 zinc finger protein 107 -2.1899
NPY4R2 neuropeptide Y receptor Y4-2 -2.18805
CCDC7 coiled-coil domain containing 7 -2.18495
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.177
PRR14L proline rich 14-like -2.1736
ADAM21 ADAM metallopeptidase domain 21 -2.1712
RIN2 Ras and Rab interactor 2 -2.16895
PRDM1 PR domain containing 1, with ZNF domain -2.1685
ANKRD7 ankyrin repeat domain 7 -2.1666
MSTN myostatin -2.1662
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.1649
LAPTM5 lysosomal protein transmembrane 5 -2.16153
PCDHGA5 protocadherin gamma subfamily A, 5 -2.1603
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.1595
MAGEC1 melanoma antigen family C1 -2.1549
SMIM5 small integral membrane protein 5 -2.15328
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -2.15115
DEFA3 defensin, alpha 3, neutrophil-specific -2.1498
RAG2 recombination activating gene 2 -2.1483
MYO3A myosin IIIA -2.147
LRP2 low density lipoprotein receptor-related protein 2 -2.14605
USP36 ubiquitin specific peptidase 36 -2.14485
ZNF248 zinc finger protein 248 -2.14465
MAGEB3 melanoma antigen family B3 -2.13875
MYO1D myosin ID -2.13755
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 -2.13595
MGAT4C MGAT4 family, member C -2.13405
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E -2.13235
NANOG Nanog homeobox -2.1321
COL8A1 collagen, type VIII, alpha 1 -2.1279
ZNF208 zinc finger protein 208 -2.1279
ZNF273 zinc finger protein 273 -2.12715
TUBA4A tubulin, alpha 4a -2.125
ADAM18 ADAM metallopeptidase domain 18 -2.1223
GUCY2F guanylate cyclase 2F, retinal -2.11945
BCL7A B-cell CLL/lymphoma 7A -2.11945
OR7E24 olfactory receptor, family 7, subfamily E, member 24 -2.11915
CUL2 cullin 2 -2.11865
CHD7 chromodomain helicase DNA binding protein 7 -2.11503
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.115
PTTG2 pituitary tumor-transforming 2 -2.1141
RAB33A RAB33A, member RAS oncogene family -2.1139
FOXN2 forkhead box N2 -2.11225
BEND5 BEN domain containing 5 -2.109
IFNA1 interferon, alpha 1 -2.10725
ACOXL acyl-CoA oxidase-like -2.1071
FPGT-TNNI3K FPGT-TNNI3K readthrough -2.107
VPREB3 pre-B lymphocyte 3 -2.10635
TH tyrosine hydroxylase -2.10455
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.10165
ZXDB zinc finger, X-linked, duplicated B -2.10065
LY75-CD302 LY75-CD302 readthrough -2.10035
LOC102724428 serine/threonine-protein kinase SIK1 -2.09975
KRT20 keratin 20, type I -2.09635
ANGPT2 angiopoietin 2 -2.09427
OR7A17 olfactory receptor, family 7, subfamily A, member 17 -2.09425
PCDHGA8 protocadherin gamma subfamily A, 8 -2.09145
PRDM5 PR domain containing 5 -2.09085
LDHAL6B lactate dehydrogenase A-like 6B -2.08645
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -2.08605
VAMP5 vesicle-associated membrane protein 5 -2.0854
MTNR1A melatonin receptor 1A -2.08305
UPK3B uroplakin 3B -2.079
KIF24 kinesin family member 24 -2.0779
UBOX5 U-box domain containing 5 -2.07757
RAD21L1 RAD21-like 1 (S. pombe) -2.0768
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -2.0694
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.0692
BTC betacellulin -2.06675
FN3KRP fructosamine 3 kinase related protein -2.0644
BCAP29 B-cell receptor-associated protein 29 -2.06385
TMLHE trimethyllysine hydroxylase, epsilon -2.06275
FAM76A family with sequence similarity 76, member A -2.06065
SMAD5 SMAD family member 5 -2.05855
TSC2 tuberous sclerosis 2 -2.0452
TEX14 testis expressed 14 -2.0437
AICDA activation-induced cytidine deaminase -2.0425
MYBPC2 myosin binding protein C, fast type -2.042
PLSCR2 phospholipid scramblase 2 -2.04195
MAPK7 mitogen-activated protein kinase 7 -2.04113
HESX1 HESX homeobox 1 -2.0395
MAGEB4 melanoma antigen family B4 -2.03775
MRPS17 mitochondrial ribosomal protein S17 -2.03725
LRRC47 leucine rich repeat containing 47 -2.03365
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa -2.03325
PMCH pro-melanin-concentrating hormone -2.03205
H2AP H2A.P histone -2.03055
MYLK3 myosin light chain kinase 3 -2.03035
ANOS1 anosmin 1 -2.0262
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 -2.0243
PCDHGA3 protocadherin gamma subfamily A, 3 -2.0239
FAM13C family with sequence similarity 13, member C -2.0223
NSUN7 NOP2/Sun domain family, member 7 -2.0191
BID BH3 interacting domain death agonist -2.01782
KNL1 kinetochore scaffold 1 -2.01665
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -2.01312
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 -2.013
SCGB2A2 secretoglobin, family 2A, member 2 -2.01265
DAZL deleted in azoospermia-like -2.0103
ZXDA zinc finger, X-linked, duplicated A -2.0102
GTPBP10 GTP-binding protein 10 (putative) -2.0101
FKBP4 FK506 binding protein 4, 59kDa -2.0098
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.00805
MSR1 macrophage scavenger receptor 1 -2.00459
ANTKMT adenine nucleotide translocase lysine methyltransferase -2.00185
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 -2.00185
AFDN afadin, adherens junction formation factor -2.00005