CRCGN017_MCF10A.WT.HP_24H:K17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminoanthracene 33.77 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CISD1 CDGSH iron sulfur domain 1 5.2569
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.03365
CIAO3 cytosolic iron-sulfur assembly component 3 4.9951
CNPY3 canopy FGF signaling regulator 3 4.22575
SNAP25 synaptosomal-associated protein, 25kDa 4.2022
TBX2 T-box 2 3.3806
ACAA1 acetyl-CoA acyltransferase 1 3.37947
WIF1 WNT inhibitory factor 1 3.2357
TPD52L2 tumor protein D52-like 2 2.8344
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.5949
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.57445
STMN2 stathmin 2 2.51708
NEFM neurofilament, medium polypeptide 2.4855
NARS1 asparaginyl-tRNA synthetase 1 2.44715
MOK MOK protein kinase 2.31385
WDR7 WD repeat domain 7 2.20585
PYCR1 pyrroline-5-carboxylate reductase 1 2.09655
SYF2 SYF2 pre-mRNA-splicing factor 2.075
MINDY1 MINDY lysine 48 deubiquitinase 1 2.0338
NSG2 neuronal vesicle trafficking associated 2 2.01285

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -5.2149
TM9SF3 transmembrane 9 superfamily member 3 -4.90005
SCYL3 SCY1-like 3 (S. cerevisiae) -4.65555
UBE3C ubiquitin protein ligase E3C -4.52955
HMG20B high mobility group 20B -4.44782
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -4.06355
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.87875
EIF5 eukaryotic translation initiation factor 5 -3.40018
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.316
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.29263
VDAC1 voltage-dependent anion channel 1 -3.02117
BPHL biphenyl hydrolase-like (serine hydrolase) -2.90275
FEM1C fem-1 homolog c (C. elegans) -2.60445
KRT14 keratin 14, type I -2.5513
MSN moesin -2.4349
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.41515
PLA2G12A phospholipase A2, group XIIA -2.28555
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.281
MYO1D myosin ID -2.2417
GAGE8 G antigen 8 -2.21116
SUCO SUN domain containing ossification factor -2.21015
POGK pogo transposable element with KRAB domain -2.1946
GSTT1 glutathione S-transferase theta 1 -2.1593
BRAF B-Raf proto-oncogene, serine/threonine kinase -2.1446
BCL10 B-cell CLL/lymphoma 10 -2.139
MT2A metallothionein 2A -2.0957
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.09485
AFF4 AF4/FMR2 family, member 4 -2.09215
CDYL chromodomain protein, Y-like -2.08932
RSF1 remodeling and spacing factor 1 -2.05075
FAM193A family with sequence similarity 193, member A -2.0493
USP36 ubiquitin specific peptidase 36 -2.00815
ZNF529 zinc finger protein 529 -2.00515