CRCGN017_MCF10A.WT.HP_24H:K19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 99.61 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

134 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.38315
PPARG peroxisome proliferator-activated receptor gamma 5.3051
CARMIL1 capping protein regulator and myosin 1 linker 1 5.01665
KDM5D lysine (K)-specific demethylase 5D 3.8816
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.71508
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.62635
FZD7 frizzled class receptor 7 3.47998
ACAA1 acetyl-CoA acyltransferase 1 3.38555
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.69895
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.64685
FBXO7 F-box protein 7 2.62515
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.60862
SMYD2 SET and MYND domain containing 2 2.5887
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.4534
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.39617
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.34705
SLC75A1 solute carrier family 75 member 1 2.26925
KMT5B lysine methyltransferase 5B 2.22545
CLOCK clock circadian regulator 2.1937
ODAM odontogenic, ameloblast asssociated 2.15675
CCDC90B coiled-coil domain containing 90B 2.1538
PYCR1 pyrroline-5-carboxylate reductase 1 2.1519
GSTK1 glutathione S-transferase kappa 1 2.14725
ZNF148 zinc finger protein 148 2.14552
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.14355
ROPN1B rhophilin associated tail protein 1B 2.13875
SIRAL2 SIR2 antiphage like 2 2.1308
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.08145
MKRN2 makorin ring finger protein 2 2.06775
ACY1 aminoacylase 1 2.06085
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.05765

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.765
LBR lamin B receptor -5.20925
HAT1 histone acetyltransferase 1 -5.0618
SGK1 serum/glucocorticoid regulated kinase 1 -5.0
RPIA ribose 5-phosphate isomerase A -4.94195
LDHD lactate dehydrogenase D -4.8636
CD58 CD58 molecule -4.36385
VAT1 vesicle amine transport 1 -4.17855
PRPF4 pre-mRNA processing factor 4 -4.135
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.69015
SMC1A structural maintenance of chromosomes 1A -3.22003
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.9484
SCTR secretin receptor -2.78485
THAP11 THAP domain containing 11 -2.76985
CTRC chymotrypsin C (caldecrin) -2.7593
CELA2A chymotrypsin-like elastase family, member 2A -2.707
CTRB2 chymotrypsinogen B2 -2.7034
WASHC4 WASH complex subunit 4 -2.69168
CTRB1 chymotrypsinogen B1 -2.6834
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.61655
CPA1 carboxypeptidase A1 (pancreatic) -2.5891
NGRN neugrin, neurite outgrowth associated -2.5882
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.58153
HOXB2 homeobox B2 -2.56695
CELA3B chymotrypsin-like elastase family, member 3B -2.5496
CELA2B chymotrypsin-like elastase family, member 2B -2.54865
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.5199
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.5119
TMC5 transmembrane channel-like 5 -2.4922
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.4655
OMD osteomodulin -2.46435
HLA-DMB major histocompatibility complex, class II, DM beta -2.46275
CTRL chymotrypsin-like -2.4599
TLCD3A TLC domain containing 3A -2.42995
ARID4B AT rich interactive domain 4B (RBP1-like) -2.42755
SEC24B SEC24 family member B -2.4128
GCG glucagon -2.40715
PNLIP pancreatic lipase -2.39015
THAP4 THAP domain containing 4 -2.3878
CELA3A chymotrypsin-like elastase family, member 3A -2.38545
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -2.3519
BIRC7 baculoviral IAP repeat containing 7 -2.34385
SSX5 synovial sarcoma, X breakpoint 5 -2.33805
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -2.32015
GAR1 GAR1 ribonucleoprotein -2.3119
CDK9 cyclin-dependent kinase 9 -2.30445
INS insulin -2.3006
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.28892
CXCL14 chemokine (C-X-C motif) ligand 14 -2.28605
RNLS renalase, FAD-dependent amine oxidase -2.2837
HSPA9 heat shock 70kDa protein 9 (mortalin) -2.2813
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -2.27877
MTCH1 mitochondrial carrier 1 -2.27335
KLK1 kallikrein 1 -2.26265
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.26261
BASP1 brain abundant, membrane attached signal protein 1 -2.24325
MN1 meningioma (disrupted in balanced translocation) 1 -2.24235
CTSK cathepsin K -2.23325
PNLIPRP1 pancreatic lipase-related protein 1 -2.23018
SNX7 sorting nexin 7 -2.2277
PLA2G1B phospholipase A2, group IB (pancreas) -2.1996
ADORA2A adenosine A2a receptor -2.19705
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -2.1799
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -2.1692
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.16845
MYH1 myosin, heavy chain 1, skeletal muscle, adult -2.1659
CLPS colipase, pancreatic -2.1595
CASKIN2 CASK interacting protein 2 -2.15345
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.1531
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 -2.15245
MXRA8 matrix-remodelling associated 8 -2.1424
MMP11 matrix metallopeptidase 11 -2.13975
PNLIPRP2 pancreatic lipase-related protein 2 -2.1363
ZNF423 zinc finger protein 423 -2.13445
CARTPT CART prepropeptide -2.13345
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 -2.10565
PDE8A phosphodiesterase 8A -2.09985
GRTP1 growth hormone regulated TBC protein 1 -2.09365
POM121 POM121 transmembrane nucleoporin -2.08895
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -2.08245
SV2C synaptic vesicle glycoprotein 2C -2.0736
CHP2 calcineurin-like EF-hand protein 2 -2.07345
ARSL arylsulfatase L -2.07145
GDF9 growth differentiation factor 9 -2.0683
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.06715
TM9SF2 transmembrane 9 superfamily member 2 -2.06555
NR4A1 nuclear receptor subfamily 4, group A, member 1 -2.06178
SLC66A2 solute carrier family 66 member 2 -2.0604
CPA2 carboxypeptidase A2 (pancreatic) -2.0584
MAGEH1 melanoma antigen family H1 -2.0584
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 -2.049
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.0482
FAM131A family with sequence similarity 131, member A -2.0427
KDM5C lysine (K)-specific demethylase 5C -2.03965
ARHGAP4 Rho GTPase activating protein 4 -2.03955
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.0354
SH2B3 SH2B adaptor protein 3 -2.02865
CIRSR corepressor of RBPJ and splicing regulator -2.02635
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 -2.02365
ZDHHC11B zinc finger, DHHC-type containing 11B -2.01305
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.00365
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.003
WNT8B wingless-type MMTV integration site family, member 8B -2.0004