CRCGN017_MCF10A.WT.HP_24H:K20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 33.2 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

91 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.85075
IGHMBP2 immunoglobulin mu binding protein 2 4.70967
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.6182
VGLL4 vestigial-like family member 4 4.44467
HLA-DMA major histocompatibility complex, class II, DM alpha 4.40285
TIAM1 T-cell lymphoma invasion and metastasis 1 4.09043
MSRA methionine sulfoxide reductase A 3.9573
WIF1 WNT inhibitory factor 1 3.91725
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.8983
MAP7 microtubule-associated protein 7 3.8729
CCP110 centriolar coiled coil protein 110kDa 3.8504
DNM1 dynamin 1 3.4802
CNPY3 canopy FGF signaling regulator 3 3.1914
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 2.76174
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.7616
E2F2 E2F transcription factor 2 2.6144
TULP4 tubby like protein 4 2.60825
CLASRP CLK4-associating serine/arginine rich protein 2.6003
EPHB3 EPH receptor B3 2.59877
LSR lipolysis stimulated lipoprotein receptor 2.5496
PLS1 plastin 1 2.5342
DAPK2 death-associated protein kinase 2 2.5336
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.50445
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.47375
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.4498
CDKN2A cyclin-dependent kinase inhibitor 2A 2.43648
SYMPK symplekin 2.3657
SIPA1 signal-induced proliferation-associated 1 2.363
EDAR ectodysplasin A receptor 2.34715
EML3 echinoderm microtubule associated protein like 3 2.34223
LGALS8 lectin, galactoside-binding, soluble, 8 2.33952
MELTF melanotransferrin 2.32675
NPIPB6 nuclear pore complex interacting protein family, member B6 2.3089
ZNF768 zinc finger protein 768 2.29425
ZNF629 zinc finger protein 629 2.25155
USP19 ubiquitin specific peptidase 19 2.2414
MAGEF1 melanoma antigen family F1 2.22425
INPP5J inositol polyphosphate-5-phosphatase J 2.22325
DEPDC5 DEP domain containing 5 2.22185
B3GAT3 beta-1,3-glucuronyltransferase 3 2.1824
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.182
CNRIP1 cannabinoid receptor interacting protein 1 2.1711
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.15785
YJU2B YJU2 splicing factor homolog B 2.15575
ESRRA estrogen-related receptor alpha 2.15403
INPPL1 inositol polyphosphate phosphatase-like 1 2.1509
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 2.14225
TPD52L1 tumor protein D52-like 1 2.1228
PRUNE1 prune exopolyphosphatase 1 2.11308
RSRC2 arginine/serine-rich coiled-coil 2 2.11197
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.07765
SPTBN5 spectrin, beta, non-erythrocytic 5 2.07315
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.05386
ZNF282 zinc finger protein 282 2.0509
SKI SKI proto-oncogene 2.04785
STRA6 stimulated by retinoic acid 6 2.04445
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 2.04262
IL36A interleukin 36, alpha 2.0421
PRPF19 pre-mRNA processing factor 19 2.0388
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.0355
PRL prolactin 2.0269
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.02685
SPDEF SAM pointed domain containing ETS transcription factor 2.02677
RAB27A RAB27A, member RAS oncogene family 2.01125

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -5.44135
MT2A metallothionein 2A -5.17565
CCNB1 cyclin B1 -5.0296
CCNB2 cyclin B2 -4.7206
BASP1 brain abundant, membrane attached signal protein 1 -4.66275
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.3001
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.9615
ETFB electron-transfer-flavoprotein, beta polypeptide -3.54625
HMG20B high mobility group 20B -3.49178
NGRN neugrin, neurite outgrowth associated -3.43595
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.39905
MT1X metallothionein 1X -2.98825
SMNDC1 survival motor neuron domain containing 1 -2.5619
WASHC4 WASH complex subunit 4 -2.5381
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.49345
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.35843
MACIR macrophage immunometabolism regulator -2.33045
CRYZ crystallin, zeta (quinone reductase) -2.2812
ORC6 origin recognition complex, subunit 6 -2.2372
CIB1 calcium and integrin binding 1 (calmyrin) -2.20825
MARCHF8 membrane associated ring-CH-type finger 8 -2.18235
STN1 STN1 subunit of CST complex -2.17495
SMG8 SMG8 nonsense mediated mRNA decay factor -2.11845
TBPL1 TBP-like 1 -2.04495
MTFR1 mitochondrial fission regulator 1 -2.04358
RAD51C RAD51 paralog C -2.03807
CBR3 carbonyl reductase 3 -2.03005