CRCGN017_MCF10A.WT.HP_24H:K21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium 4-((e)-{5-methoxy-4-[(e)-(4-methoxyphenyl)diazenyl]-2-methylphenyl}diazenyl)benzenesulfonate 11.07 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:K21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.92
ARL4C ADP-ribosylation factor-like 4C 4.84393
WIF1 WNT inhibitory factor 1 4.8015
MSRA methionine sulfoxide reductase A 4.02705
KIF5C kinesin family member 5C 3.9603
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.74845
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.2157
ADRB2 adrenoceptor beta 2, surface 2.56925
SKAP2 src kinase associated phosphoprotein 2 2.41413
PGK1 phosphoglycerate kinase 1 2.3459
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.30365
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.2306
FAM114A2 family with sequence similarity 114, member A2 2.1929
LMAN2L lectin, mannose-binding 2-like 2.1351
CCDC90B coiled-coil domain containing 90B 2.0172
LOC100533997 MAGEA10-MAGEA5 readthrough 2.01125
VBP1 von Hippel-Lindau binding protein 1 2.01005
YIPF5 Yip1 domain family, member 5 2.0032

decreased expression

Symbol Name Standardized Value
TUBB6 tubulin, beta 6 class V -5.4488
MRPS2 mitochondrial ribosomal protein S2 -5.4032
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.0
SLC25A46 solute carrier family 25, member 46 -4.70375
TRAPPC3 trafficking protein particle complex 3 -4.1803
NRIP1 nuclear receptor interacting protein 1 -4.08362
CD44 CD44 molecule (Indian blood group) -3.90109
BASP1 brain abundant, membrane attached signal protein 1 -3.69625
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.34335
MRPS15 mitochondrial ribosomal protein S15 -3.15455
MPC2 mitochondrial pyruvate carrier 2 -3.04165
CD81 CD81 molecule -3.00105
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.9519
SGK1 serum/glucocorticoid regulated kinase 1 -2.87095
MT2A metallothionein 2A -2.83525
ACAA1 acetyl-CoA acyltransferase 1 -2.72678
STK25 serine/threonine kinase 25 -2.6933
MAP7D1 MAP7 domain containing 1 -2.6559
PLA1A phospholipase A1 member A -2.60125
TKT transketolase -2.5801
GDF15 growth differentiation factor 15 -2.5291
WASHC4 WASH complex subunit 4 -2.48715
SEC16A SEC16 homolog A (S. cerevisiae) -2.4229
EIF3A eukaryotic translation initiation factor 3, subunit A -2.34198
PAEP progestagen-associated endometrial protein -2.3116
CHPF2 chondroitin polymerizing factor 2 -2.25795
ATXN7 ataxin 7 -2.22315
ADAMTSL3 ADAMTS-like 3 -2.21845
BFSP2 beaded filament structural protein 2, phakinin -2.1789
MED13 mediator complex subunit 13 -2.1737
COL15A1 collagen, type XV, alpha 1 -2.12245
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.1079
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.08348
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -2.06955
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.0408
EVI2B ecotropic viral integration site 2B -2.03915
PFKM phosphofructokinase, muscle -2.01785
DOCK2 dedicator of cytokinesis 2 -2.0132
F5 coagulation factor V (proaccelerin, labile factor) -2.00452