CRCGN017_MCF10A.WT.HP_24H:L02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o-nitrotoluene 33.6 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.18732
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.10418
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.77735
KLHL21 kelch-like family member 21 3.3358
SPAG4 sperm associated antigen 4 3.2826
C2CD2 C2 calcium-dependent domain containing 2 3.25563
LOXL1 lysyl oxidase-like 1 3.1923
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.14637
HBB hemoglobin, beta 3.09642
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.07988
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.92518
HBA1 hemoglobin, alpha 1 2.90146
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.7831
CCL2 chemokine (C-C motif) ligand 2 2.67513
PRR14L proline rich 14-like 2.64813
WASF3 WAS protein family, member 3 2.47212
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.39794
ZNF586 zinc finger protein 586 2.17178
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.15669
KIF5C kinesin family member 5C 2.13675
MYOM1 myomesin 1 2.11065
TM6SF1 transmembrane 6 superfamily member 1 2.02595
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 2.00911

decreased expression

Symbol Name Standardized Value
TSPAN4 tetraspanin 4 -3.92086
PARP2 poly (ADP-ribose) polymerase 2 -3.77917
KRT14 keratin 14, type I -3.52812
ETFB electron-transfer-flavoprotein, beta polypeptide -2.83934
PLK1 polo-like kinase 1 -2.63204
MT2A metallothionein 2A -2.54067
WASHC4 WASH complex subunit 4 -2.52978
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.5249
NUP85 nucleoporin 85kDa -2.50437
TLCD3A TLC domain containing 3A -2.37229
ADI1 acireductone dioxygenase 1 -2.36504
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.26605
TOMM34 translocase of outer mitochondrial membrane 34 -2.20582
SUMO4 small ubiquitin-like modifier 4 -2.06527
RPS5 ribosomal protein S5 -2.01136