CRCGN017_MCF10A.WT.HP_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrylonitrile 38.09 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 4.85688
AMDHD2 amidohydrolase domain containing 2 4.2376
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 4.07242
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.3009
GET1 guided entry of tail-anchored proteins factor 1 3.25775
ACAA1 acetyl-CoA acyltransferase 1 3.25218
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 3.12045
NUCB2 nucleobindin 2 2.53135
PRR15L proline rich 15-like 2.401
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.1524
SLC38A2 solute carrier family 38, member 2 2.03915

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -9.05235
UFM1 ubiquitin-fold modifier 1 -5.0195
MCUR1 mitochondrial calcium uniporter regulator 1 -4.2685
STXBP2 syntaxin binding protein 2 -3.5809
LYPLA1 lysophospholipase I -3.46985
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.37315
OXA1L oxidase (cytochrome c) assembly 1-like -2.9281
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.80058
MSN moesin -2.4505
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.367
HSPA1A heat shock 70kDa protein 1A -2.33165
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.1953
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 -2.15385
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.13685
FLNA filamin A, alpha -2.10357
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.0965