CRCGN017_MCF10A.WT.HP_24H:L09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrylonitrile 12.7 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.367
KIF5C kinesin family member 5C 4.2414
MAP7 microtubule-associated protein 7 4.22408
GSTZ1 glutathione S-transferase zeta 1 3.5267
TBPL1 TBP-like 1 2.96655
ZW10 zw10 kinetochore protein 2.64095
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.55708
EIF3H eukaryotic translation initiation factor 3, subunit H 2.3329
YBX2 Y box binding protein 2 2.3278
EFHD1 EF-hand domain family, member D1 2.3228
CNRIP1 cannabinoid receptor interacting protein 1 2.304
RASL11B RAS-like, family 11, member B 2.2739
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.1991
KNTC1 kinetochore associated 1 2.1822
GHR growth hormone receptor 2.16355
LEFTY2 left-right determination factor 2 2.1489
MAP3K5 mitogen-activated protein kinase kinase kinase 5 2.1486
TBC1D31 TBC1 domain family, member 31 2.13335
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.13105
ZCWPW1 zinc finger, CW type with PWWP domain 1 2.11915
S100PBP S100P binding protein 2.02835
FCHO1 FCH domain only 1 2.01705
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.00493

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -9.3316
HMG20B high mobility group 20B -5.92292
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -5.3261
USP6NL USP6 N-terminal like -4.54415
FPGS folylpolyglutamate synthase -3.51545
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.01493
THAP11 THAP domain containing 11 -2.7262
CSK c-src tyrosine kinase -2.6799
ETFB electron-transfer-flavoprotein, beta polypeptide -2.65405
ACAA1 acetyl-CoA acyltransferase 1 -2.6128
PCCB propionyl CoA carboxylase, beta polypeptide -2.5047
MIA melanoma inhibitory activity -2.4126
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.34132
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.2731
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -2.13135
OSBPL10 oxysterol binding protein-like 10 -2.1309
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.0839
MLEC malectin -2.01653