CRCGN017_MCF10A.WT.HP_24H:L10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isoprene 99.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.95795
SNAP25 synaptosomal-associated protein, 25kDa 4.87762
PEX11A peroxisomal biogenesis factor 11 alpha 4.6829
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.5916
MYLK myosin light chain kinase 3.9685
WIF1 WNT inhibitory factor 1 3.70985
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.22148
NSG2 neuronal vesicle trafficking associated 2 3.07285
HBB hemoglobin, beta 2.78787
CNRIP1 cannabinoid receptor interacting protein 1 2.63125
ADRB2 adrenoceptor beta 2, surface 2.56345
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.1901
MYH11 myosin, heavy chain 11, smooth muscle 2.10523

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -4.52685
JMJD6 jumonji domain containing 6 -4.20125
NT5DC2 5'-nucleotidase domain containing 2 -4.091
TMEM50A transmembrane protein 50A -3.8029
COPS7A COP9 signalosome subunit 7A -3.59825
KRT14 keratin 14, type I -3.36235
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.2367
NGRN neugrin, neurite outgrowth associated -3.08045
WASHC4 WASH complex subunit 4 -2.89385
CREG1 cellular repressor of E1A-stimulated genes 1 -2.87
SGK1 serum/glucocorticoid regulated kinase 1 -2.6848
MXRA7 matrix-remodelling associated 7 -2.5067
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.49005
DCK deoxycytidine kinase -2.48105
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.34543
PTX3 pentraxin 3, long -2.1527
MSN moesin -2.09755
BCOR BCL6 corepressor -2.09135
GDF15 growth differentiation factor 15 -2.0622
SPRED2 sprouty-related, EVH1 domain containing 2 -2.028