CRCGN017_MCF10A.WT.HP_24H:L11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isoprene 33.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 10.0
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 7.5378
WASF3 WAS protein family, member 3 6.7599
RPP38 ribonuclease P/MRP 38kDa subunit 3.0805
MICALL1 MICAL-like 1 2.86135
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 2.6868
NT5DC3 5'-nucleotidase domain containing 3 2.5265
EDN1 endothelin 1 2.5231
SKIC8 SKI8 subunit of superkiller complex 2.18155
TBC1D4 TBC1 domain family, member 4 2.16945
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.162
MRPL37 mitochondrial ribosomal protein L37 2.1512
SCAND1 SCAN domain containing 1 2.1258
PWP1 PWP1 homolog (S. cerevisiae) 2.1251
PLSCR3 phospholipid scramblase 3 2.12315
ADGRA3 adhesion G protein-coupled receptor A3 2.1071
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.0965
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 2.0799
CTSC cathepsin C 2.0484
OLFML2B olfactomedin-like 2B 2.0246
HELZ helicase with zinc finger 2.0058

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -6.4791
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.2907
MEST mesoderm specific transcript -3.6714
MSN moesin -3.4483
CDKN2A cyclin-dependent kinase inhibitor 2A -3.27347
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.0661
XPO7 exportin 7 -2.9616
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.8803
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -2.55705
MTERF3 mitochondrial transcription termination factor 3 -2.4965
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.437
FGF9 fibroblast growth factor 9 -2.3585
EMC2 ER membrane protein complex subunit 2 -2.3089
LDHC lactate dehydrogenase C -2.3021
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.2145
PDZK1 PDZ domain containing 1 -2.1032
GABPB1 GA binding protein transcription factor, beta subunit 1 -2.095
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled -2.0884
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.0549
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.0523
PLAAT4 phospholipase A and acyltransferase 4 -2.0416
NHERF4 NHERF family PDZ scaffold protein 4 -2.0372