CRCGN017_MCF10A.WT.HP_24H:L13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-nitropropane 98.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 5.1659
IDE insulin-degrading enzyme 4.3443
HBA1 hemoglobin, alpha 1 3.94593
HBB hemoglobin, beta 3.87858
ANO10 anoctamin 10 3.53845
VAV3 vav 3 guanine nucleotide exchange factor 3.22105
LOC122526780 uncharacterized LOC122526780 3.2057
GARRE1 granule associated Rac and RHOG effector 1 3.1093
IGHMBP2 immunoglobulin mu binding protein 2 3.03123
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.9838
GPATCH8 G patch domain containing 8 2.94195
FGFR4 fibroblast growth factor receptor 4 2.92217
BZW2 basic leucine zipper and W2 domains 2 2.64055
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 2.2817
ZBTB35 zinc finger and BTB domain containing 35 2.2555
HDGFL3 HDGF like 3 2.24784
POF1B premature ovarian failure, 1B 2.11275
THAP12 THAP domain containing 12 2.09695
SNX15 sorting nexin 15 2.04105
CRIPTO3 cripto, EGF-CFC family member 3 2.03225
PKN1 protein kinase N1 2.01673
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.015
TOM1L1 target of myb1 (chicken)-like 1 2.01475

decreased expression

Symbol Name Standardized Value
CHIC2 cysteine-rich hydrophobic domain 2 -5.9559
ACOT9 acyl-CoA thioesterase 9 -5.53215
KIF20A kinesin family member 20A -5.1156
OXA1L oxidase (cytochrome c) assembly 1-like -4.76575
DNM1L dynamin 1-like -4.628
COPS7A COP9 signalosome subunit 7A -4.4914
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.195
CD44 CD44 molecule (Indian blood group) -4.08462
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.7869
THAP11 THAP domain containing 11 -3.6079
MSN moesin -2.8503
IGFBP7 insulin-like growth factor binding protein 7 -2.66712
ACAA1 acetyl-CoA acyltransferase 1 -2.56253
MED21 mediator complex subunit 21 -2.48522
PANK4 pantothenate kinase 4 -2.46295
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.33895
PFN1 profilin 1 -2.3199
NECAP1 NECAP endocytosis associated 1 -2.3182
GMPR2 guanosine monophosphate reductase 2 -2.314
EN1 engrailed homeobox 1 -2.1857
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A -2.1782
NANOS3 nanos homolog 3 (Drosophila) -2.16855
MARCO macrophage receptor with collagenous structure -2.0907
SGK1 serum/glucocorticoid regulated kinase 1 -2.0181