CRCGN017_MCF10A.WT.HP_24H:L15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-nitropropane 10.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

101 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 10.0
WIF1 WNT inhibitory factor 1 7.22765
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.7009
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.12397
GPER1 G protein-coupled estrogen receptor 1 4.7727
SPAG4 sperm associated antigen 4 4.7671
MAP7 microtubule-associated protein 7 4.47003
NEFM neurofilament, medium polypeptide 4.26505
STMN2 stathmin 2 4.11305
NEFL neurofilament, light polypeptide 3.709
NSG2 neuronal vesicle trafficking associated 2 3.69505
SNAP91 synaptosomal-associated protein, 91kDa 2.9942
CHGB chromogranin B 2.84425
TAC1 tachykinin, precursor 1 2.66895
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.606
DENND2D DENN/MADD domain containing 2D 2.5975
SYT1 synaptotagmin I 2.58255
RUNDC3A RUN domain containing 3A 2.51443
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.4984
LETMD1 LETM1 domain containing 1 2.4981
LGI1 leucine-rich, glioma inactivated 1 2.48105
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.47605
EFNA3 ephrin-A3 2.47055
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.4014
INTS3 integrator complex subunit 3 2.36435
SYN1 synapsin I 2.35365
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.3197
RUNDC3B RUN domain containing 3B 2.31385
TRIP6 thyroid hormone receptor interactor 6 2.29905
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2.281
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.2662
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.2553
VSNL1 visinin-like 1 2.24697
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.2455
RGS7 regulator of G-protein signaling 7 2.23795
ZIC1 Zic family member 1 2.23115
CDH18 cadherin 18, type 2 2.22495
ACTL6B actin-like 6B 2.21147
ASPA aspartoacylase 2.19965
OGDHL oxoglutarate dehydrogenase-like 2.1983
SCG3 secretogranin III 2.19495
POLL polymerase (DNA directed), lambda 2.14005
ETNPPL ethanolamine-phosphate phospho-lyase 2.1346
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.12683
SCG2 secretogranin II 2.125
ESRRG estrogen-related receptor gamma 2.12052
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.1038
GPM6A glycoprotein M6A 2.10327
MXD3 MAX dimerization protein 3 2.0788
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.067
ERMP1 endoplasmic reticulum metallopeptidase 1 2.0626
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.0595
PNPO pyridoxamine 5'-phosphate oxidase 2.01765
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.00705
FKBP5 FK506 binding protein 5 2.00135

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -10.0
TUBB6 tubulin, beta 6 class V -5.0
SGK1 serum/glucocorticoid regulated kinase 1 -4.6115
MT2A metallothionein 2A -4.37775
HMG20B high mobility group 20B -4.2921
RNF111 ring finger protein 111 -4.02925
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -3.5731
ELAC2 elaC ribonuclease Z 2 -3.4863
GDF15 growth differentiation factor 15 -3.3743
COPS7A COP9 signalosome subunit 7A -3.0727
FJX1 four jointed box 1 (Drosophila) -3.01885
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.9073
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.87763
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.779
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -2.7534
KRT14 keratin 14, type I -2.68985
MSN moesin -2.6287
TCF12 transcription factor 12 -2.60965
ANXA2 annexin A2 -2.54965
MT1X metallothionein 1X -2.45688
RBM15B RNA binding motif protein 15B -2.43875
NMRK2 nicotinamide riboside kinase 2 -2.424
IL7R interleukin 7 receptor -2.4236
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine -2.3842
TNNC2 troponin C type 2 (fast) -2.2777
TTI2 TELO2 interacting protein 2 -2.2381
TPRA1 transmembrane protein, adipocyte asscociated 1 -2.22405
INTS14 integrator complex subunit 14 -2.20185
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.178
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.13075
TXNRD1 thioredoxin reductase 1 -2.12835
HMG20A high mobility group 20A -2.1099
ANKRD10 ankyrin repeat domain 10 -2.0746
RNF144A ring finger protein 144A -2.07225
PRRX1 paired related homeobox 1 -2.0658
METTL1 methyltransferase like 1 -2.0616
JADE3 jade family PHD finger 3 -2.05935
MYL2 myosin, light chain 2, regulatory, cardiac, slow -2.05665
NOPCHAP1 NOP protein chaperone 1 -2.05495
GRK3 G protein-coupled receptor kinase 3 -2.05312
UCMA upper zone of growth plate and cartilage matrix associated -2.0412
WASHC4 WASH complex subunit 4 -2.0406
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.03998
MYL1 myosin, light chain 1, alkali; skeletal, fast -2.0391
SNX7 sorting nexin 7 -2.02825
BRD9 bromodomain containing 9 -2.0177