CRCGN017_MCF10A.WT.HP_24H:L16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethyl methanesulfonate 101.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.78515
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.66275
FKBP14 FK506 binding protein 14, 22 kDa 4.52235
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 4.48765
VGLL4 vestigial-like family member 4 3.94292
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3.31668
TIAM1 T-cell lymphoma invasion and metastasis 1 3.26252
IGHMBP2 immunoglobulin mu binding protein 2 3.07383
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.8193
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.19695
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.1752
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.1712
MSL1 male-specific lethal 1 homolog (Drosophila) 2.1421
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.0818
TSPAN14 tetraspanin 14 2.05995
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.02257
GMPS guanine monphosphate synthase 2.00085

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -5.20485
C2CD5 C2 calcium-dependent domain containing 5 -5.1281
S100A8 S100 calcium binding protein A8 -4.69075
KIF14 kinesin family member 14 -4.60445
KIF20A kinesin family member 20A -4.3557
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.05555
MT2A metallothionein 2A -3.95925
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.93015
HMG20B high mobility group 20B -3.92315
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.59225
MT1X metallothionein 1X -3.5811
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.0216
BASP1 brain abundant, membrane attached signal protein 1 -2.88135
RAI14 retinoic acid induced 14 -2.87045
NUSAP1 nucleolar and spindle associated protein 1 -2.8437
RECQL RecQ helicase-like -2.56597
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.54585
CSRP1 cysteine and glycine-rich protein 1 -2.3825
WASHC4 WASH complex subunit 4 -2.15723
SGK1 serum/glucocorticoid regulated kinase 1 -2.0633
LRRC47 leucine rich repeat containing 47 -2.0074