CRCGN017_MCF10A.WT.HP_24H:L17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethyl methanesulfonate 33.77 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 5.13775
SPAG4 sperm associated antigen 4 5.11285
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.6327
RPL39L ribosomal protein L39-like 4.1889
PLSCR1 phospholipid scramblase 1 3.33092
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.1242
MINDY1 MINDY lysine 48 deubiquitinase 1 2.10355
PTK2 protein tyrosine kinase 2 2.05538
DBR1 debranching RNA lariats 1 2.02195

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -5.3241
TES testin LIM domain protein -4.70505
NPDC1 neural proliferation, differentiation and control, 1 -4.67995
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.6551
DYNLT3 dynein, light chain, Tctex-type 3 -3.9785
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.73185
NGRN neugrin, neurite outgrowth associated -3.276
UBE3C ubiquitin protein ligase E3C -2.9808
ACAA1 acetyl-CoA acyltransferase 1 -2.77752
NVL nuclear VCP-like -2.3662
CXCL9 chemokine (C-X-C motif) ligand 9 -2.17555
SNX7 sorting nexin 7 -2.14025
RAMP2 receptor (G protein-coupled) activity modifying protein 2 -2.1357
TRIB3 tribbles pseudokinase 3 -2.04975
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.01155
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -2.00915