CRCGN017_MCF10A.WT.HP_24H:L18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethyl methanesulfonate 11.26 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8738
EAPP E2F-associated phosphoprotein 4.8494
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.81852
ADGRE5 adhesion G protein-coupled receptor E5 4.7626
E2F2 E2F transcription factor 2 4.7523
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.74255
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 4.2064
TIAM1 T-cell lymphoma invasion and metastasis 1 3.37855
SRP54 signal recognition particle 54kDa 3.0771
CCL2 chemokine (C-C motif) ligand 2 2.9261
MTA2 metastasis associated 1 family, member 2 2.66425
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.64981
SPTSSA serine palmitoyltransferase, small subunit A 2.58168
FOXC1 forkhead box C1 2.39795
ZNF148 zinc finger protein 148 2.3691
DCAF6 DDB1 and CUL4 associated factor 6 2.36335
FBXO7 F-box protein 7 2.3285
STRN3 striatin, calmodulin binding protein 3 2.23865
CCNT1 cyclin T1 2.2117
STAG2 stromal antigen 2 2.16792
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.164
MORF4L1 mortality factor 4 like 1 2.11955
ADD3 adducin 3 (gamma) 2.11872
BAZ1A bromodomain adjacent to zinc finger domain, 1A 2.11597
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.031
CD9 CD9 molecule 2.02035
STAMBP STAM binding protein 2.00105

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.4855
S100A8 S100 calcium binding protein A8 -5.0
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.78315
TXNDC9 thioredoxin domain containing 9 -4.62295
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -4.14705
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.58068
ELAC2 elaC ribonuclease Z 2 -3.57995
VDAC1 voltage-dependent anion channel 1 -3.31023
MT2A metallothionein 2A -3.2634
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.15197
ARID4B AT rich interactive domain 4B (RBP1-like) -2.8465
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.8424
SGK1 serum/glucocorticoid regulated kinase 1 -2.7715
BASP1 brain abundant, membrane attached signal protein 1 -2.6414
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.37315
PUM3 pumilio RNA binding family member 3 -2.3616
MT1X metallothionein 1X -2.3431
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -2.32625
HLA-DOB major histocompatibility complex, class II, DO beta -2.28475
MRPS17 mitochondrial ribosomal protein S17 -2.2685
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -2.2675
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -2.26545
FGF7 fibroblast growth factor 7 -2.21415
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -2.193
MAN2C1 mannosidase, alpha, class 2C, member 1 -2.19255
TNIP3 TNFAIP3 interacting protein 3 -2.1667
TXNL1 thioredoxin-like 1 -2.1553
ALPL alkaline phosphatase, liver/bone/kidney -2.1511
GCH1 GTP cyclohydrolase 1 -2.14725
CUTA cutA divalent cation tolerance homolog (E. coli) -2.0492
SNX7 sorting nexin 7 -2.0434
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.03145
MAIP1 matrix AAA peptidase interacting protein 1 -2.00245