CRCGN017_MCF10A.WT.HP_24H:L19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 97.79 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

301 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 8.4585
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.5957
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 6.2789
GLRX glutaredoxin (thioltransferase) 6.07363
RPN1 ribophorin I 5.86935
SLC35B1 solute carrier family 35, member B1 5.74485
GFPT1 glutamine--fructose-6-phosphate transaminase 1 5.54435
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 5.02685
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.61151
WFS1 Wolfram syndrome 1 (wolframin) 4.18675
AARS1 alanyl-tRNA synthetase 1 4.15545
PYCR1 pyrroline-5-carboxylate reductase 1 3.8905
SIRT3 sirtuin 3 3.86525
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 3.8343
PECR peroxisomal trans-2-enoyl-CoA reductase 3.82865
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.7919
PHGDH phosphoglycerate dehydrogenase 3.72443
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.71529
CARS1 cysteinyl-tRNA synthetase 1 3.70063
TRIB3 tribbles pseudokinase 3 3.60255
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.57413
NLRP4 NLR family, pyrin domain containing 4 3.53635
FICD FIC domain containing 3.3926
HBA1 hemoglobin, alpha 1 3.38404
NOSIP nitric oxide synthase interacting protein 3.32485
RBKS ribokinase 3.2952
UFM1 ubiquitin-fold modifier 1 3.27215
WASF3 WAS protein family, member 3 3.26355
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 3.11207
GARS1 glycyl-tRNA synthetase 1 3.0372
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 3.018
IFT88 intraflagellar transport 88 3.01125
ATRAID all-trans retinoic acid-induced differentiation factor 2.99805
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.9945
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.9791
PDIA6 protein disulfide isomerase family A, member 6 2.93584
UGDH UDP-glucose 6-dehydrogenase 2.92775
MINDY1 MINDY lysine 48 deubiquitinase 1 2.91785
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.85935
KDM5D lysine (K)-specific demethylase 5D 2.84755
SSR4 signal sequence receptor, delta 2.8394
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.82735
MANF mesencephalic astrocyte-derived neurotrophic factor 2.8249
TMEM214 transmembrane protein 214 2.81335
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.8031
IL17RA interleukin 17 receptor A 2.7697
SQSTM1 sequestosome 1 2.7293
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.72135
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.7106
RNF103 ring finger protein 103 2.6808
TXNDC15 thioredoxin domain containing 15 2.6715
POGLUT1 protein O-glucosyltransferase 1 2.6688
GRB10 growth factor receptor-bound protein 10 2.64882
LOC128125814 uncharacterized LOC128125814 2.6271
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.61685
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.5768
LETMD1 LETM1 domain containing 1 2.5645
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.5602
TRAPPC6A trafficking protein particle complex 6A 2.5544
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.5519
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.54915
SLC35F6 solute carrier family 35, member F6 2.5488
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.53425
USP9Y ubiquitin specific peptidase 9, Y-linked 2.53123
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.51855
WHR1 winged helix repair factor 1 2.50283
TMED2 transmembrane emp24 domain trafficking protein 2 2.48218
PADI2 peptidyl arginine deiminase, type II 2.47885
MAN2A1 mannosidase, alpha, class 2A, member 1 2.478
HHIPL2 HHIP-like 2 2.4754
MAGT1 magnesium transporter 1 2.47395
RBBP5 retinoblastoma binding protein 5 2.471
PSENEN presenilin enhancer gamma secretase subunit 2.4616
OARD1 O-acyl-ADP-ribose deacylase 1 2.4532
FKBP14 FK506 binding protein 14, 22 kDa 2.4468
SPDEF SAM pointed domain containing ETS transcription factor 2.43378
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.4326
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.3911
ACOX2 acyl-CoA oxidase 2, branched chain 2.3905
CCPG1 cell cycle progression 1 2.38981
CANX calnexin 2.3869
SH3YL1 SH3 and SYLF domain containing 1 2.3821
RABAC1 Rab acceptor 1 (prenylated) 2.36205
DAD1 defender against cell death 1 2.361
LOC124900388 uncharacterized LOC124900388 2.35885
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.34955
CKAP4 cytoskeleton-associated protein 4 2.34263
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.33972
FNDC4 fibronectin type III domain containing 4 2.32315
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.31555
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.31125
VCAN versican 2.30341
MAP2K5 mitogen-activated protein kinase kinase 5 2.30205
BBC3 BCL2 binding component 3 2.30055
MDM4 MDM4, p53 regulator 2.29765
ATF4 activating transcription factor 4 2.27625
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 2.27555
COPG1 coatomer protein complex, subunit gamma 1 2.27105
PRSS23 protease, serine, 23 2.2682
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.25435
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 2.25005
SCCPDH saccharopine dehydrogenase (putative) 2.24757
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.2475
RGN regucalcin 2.238
MYOZ3 myozenin 3 2.2359
TMEM80 transmembrane protein 80 2.23285
TERF2IP telomeric repeat binding factor 2, interacting protein 2.2296
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 2.22867
NLK nemo-like kinase 2.2194
CCNT1 cyclin T1 2.21195
MYO9A myosin IXA 2.21175
IFRD1 interferon-related developmental regulator 1 2.19545
CRABP1 cellular retinoic acid binding protein 1 2.19295
PREB prolactin regulatory element binding 2.1928
METTL25B methyltransferase like 25B 2.19105
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.19022
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.188
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.1858
GATA3 GATA binding protein 3 2.18117
TMED9 transmembrane emp24 protein transport domain containing 9 2.18012
LBP lipopolysaccharide binding protein 2.17388
HBB hemoglobin, beta 2.17113
ZNF195 zinc finger protein 195 2.16705
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.1638
CYB561 cytochrome b561 2.16236
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.16165
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 2.1605
SEC61B Sec61 beta subunit 2.1542
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.14515
PRKCQ protein kinase C, theta 2.14458
THADA thyroid adenoma associated 2.14068
AKTIP AKT interacting protein 2.13625
PRR7 proline rich 7 (synaptic) 2.13585
ZMYM2 zinc finger, MYM-type 2 2.12645
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 2.1247
TM9SF2 transmembrane 9 superfamily member 2 2.12045
CCDC71 coiled-coil domain containing 71 2.11935
PLCB4 phospholipase C, beta 4 2.1187
SLC67A1 solute carrier family 67 member 1 2.11805
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.1167
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.11532
FKBP11 FK506 binding protein 11, 19 kDa 2.10115
LOXL1 lysyl oxidase-like 1 2.09885
INHBE inhibin, beta E 2.08655
SRPRB signal recognition particle receptor, B subunit 2.08115
UNC50 unc-50 homolog (C. elegans) 2.0806
SIL1 SIL1 nucleotide exchange factor 2.07935
MYBPH myosin binding protein H 2.07925
CHPF chondroitin polymerizing factor 2.07815
HOOK1 hook microtubule-tethering protein 1 2.0759
GORASP2 golgi reassembly stacking protein 2, 55kDa 2.06802
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.064
SRP19 signal recognition particle 19kDa 2.06332
APOE apolipoprotein E 2.06283
PGM3 phosphoglucomutase 3 2.06278
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.06225
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.0557
GGPS1 geranylgeranyl diphosphate synthase 1 2.05373
CGREF1 cell growth regulator with EF-hand domain 1 2.041
CXCL12 chemokine (C-X-C motif) ligand 12 2.03608
FYN FYN proto-oncogene, Src family tyrosine kinase 2.0348
MYDGF myeloid-derived growth factor 2.03393
PDIA4 protein disulfide isomerase family A, member 4 2.03167
SERP1 stress-associated endoplasmic reticulum protein 1 2.03143
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.0307
EIF3E eukaryotic translation initiation factor 3, subunit E 2.0302
ADA adenosine deaminase 2.0297
RNF122 ring finger protein 122 2.02535
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.0251
ITM2C integral membrane protein 2C 2.0215
HDLBP high density lipoprotein binding protein 2.01775
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.01245
CLDN6 claudin 6 2.0105
ACAD10 acyl-CoA dehydrogenase family, member 10 2.0058
CCL16 chemokine (C-C motif) ligand 16 2.0035
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.0022

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -5.9858
KRT14 keratin 14, type I -4.86075
DCK deoxycytidine kinase -4.31805
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -4.2045
SMNDC1 survival motor neuron domain containing 1 -4.0023
BACE2 beta-site APP-cleaving enzyme 2 -3.85925
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.76285
TUBA4A tubulin, alpha 4a -3.76165
NUP93 nucleoporin 93kDa -3.66605
AKT1 v-akt murine thymoma viral oncogene homolog 1 -3.465
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.456
FPGS folylpolyglutamate synthase -3.4262
TK1 thymidine kinase 1, soluble -3.4128
CDR2L cerebellar degeneration-related protein 2-like -3.36535
SMC1A structural maintenance of chromosomes 1A -3.31615
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -3.2544
CAB39 calcium binding protein 39 -3.22295
SNX7 sorting nexin 7 -3.0882
NELFCD negative elongation factor complex member C/D -2.8698
YAP1 Yes-associated protein 1 -2.86795
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.85593
TRIP13 thyroid hormone receptor interactor 13 -2.7693
ASF1B anti-silencing function 1B histone chaperone -2.75
MAP7D1 MAP7 domain containing 1 -2.7258
ZNF185 zinc finger protein 185 (LIM domain) -2.72015
GPN2 GPN-loop GTPase 2 -2.6996
CDC20 cell division cycle 20 -2.69155
CCNA2 cyclin A2 -2.67817
UBA1 ubiquitin-like modifier activating enzyme 1 -2.63455
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.62372
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.57285
HSPB1 heat shock 27kDa protein 1 -2.5573
OXSR1 oxidative stress responsive 1 -2.5477
PISD phosphatidylserine decarboxylase -2.5242
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.5208
MRPS2 mitochondrial ribosomal protein S2 -2.51245
LOC100533997 MAGEA10-MAGEA5 readthrough -2.5007
RAD51C RAD51 paralog C -2.4996
AURKB aurora kinase B -2.4918
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.47442
PUDP pseudouridine 5'-phosphatase -2.47025
MICALL1 MICAL-like 1 -2.46885
STMN1 stathmin 1 -2.4686
AURKA aurora kinase A -2.45832
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -2.4476
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.44755
TUBB6 tubulin, beta 6 class V -2.4465
RPA3 replication protein A3, 14kDa -2.44515
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.44035
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.4352
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.42765
AMDHD2 amidohydrolase domain containing 2 -2.41305
BCL7B B-cell CLL/lymphoma 7B -2.4082
MAGEA1 melanoma antigen family A1 -2.4021
MVP major vault protein -2.3954
CRYZ crystallin, zeta (quinone reductase) -2.39075
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.3814
UBE2A ubiquitin-conjugating enzyme E2A -2.38013
HEATR1 HEAT repeat containing 1 -2.36845
TAC4 tachykinin 4 (hemokinin) -2.35695
FASTKD5 FAST kinase domains 5 -2.35335
LBR lamin B receptor -2.345
GTF2A2 general transcription factor IIA, 2, 12kDa -2.3354
TATDN2 TatD DNase domain containing 2 -2.3301
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -2.3215
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.32081
CDC45 cell division cycle 45 -2.31505
EIF3B eukaryotic translation initiation factor 3, subunit B -2.30145
CD320 CD320 molecule -2.2853
CSAG2 CSAG family, member 2 -2.284
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -2.27267
LHX1 LIM homeobox 1 -2.26145
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.25575
MGA MGA, MAX dimerization protein -2.25545
TM9SF3 transmembrane 9 superfamily member 3 -2.25015
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.245
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.2381
SFTPD surfactant protein D -2.22495
MAGEA12 melanoma antigen family A12 -2.22335
KIF20A kinesin family member 20A -2.2187
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.20795
MRPL58 mitochondrial ribosomal protein L58 -2.20255
NUP153 nucleoporin 153kDa -2.187
EXOC3 exocyst complex component 3 -2.17385
IGFBP7 insulin-like growth factor binding protein 7 -2.173
HAT1 histone acetyltransferase 1 -2.15475
MRPS17 mitochondrial ribosomal protein S17 -2.15335
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.15325
MCMBP minichromosome maintenance complex binding protein -2.153
CBX1 chromobox homolog 1 -2.1488
ADRB2 adrenoceptor beta 2, surface -2.1465
PES1 pescadillo ribosomal biogenesis factor 1 -2.1448
FLNA filamin A, alpha -2.13642
FASTKD3 FAST kinase domains 3 -2.1329
MAGEA2B melanoma antigen family A2B -2.12885
CRLF3 cytokine receptor-like factor 3 -2.1243
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.1221
CCNF cyclin F -2.11885
MRPS7 mitochondrial ribosomal protein S7 -2.112
VRK1 vaccinia related kinase 1 -2.11085
PPP6R1 protein phosphatase 6, regulatory subunit 1 -2.09285
SLIT2 slit homolog 2 (Drosophila) -2.09275
MED17 mediator complex subunit 17 -2.0851
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.07675
RNASE7 ribonuclease, RNase A family, 7 -2.0717
SPC25 SPC25, NDC80 kinetochore complex component -2.06585
BAG3 BCL2-associated athanogene 3 -2.06345
NELFB negative elongation factor complex member B -2.05685
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -2.05568
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.0536
CAV2 caveolin 2 -2.05065
HPS6 Hermansky-Pudlak syndrome 6 -2.0463
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.0407
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -2.03505
FAM193A family with sequence similarity 193, member A -2.03495
FPGT fucose-1-phosphate guanylyltransferase -2.0342
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.03035
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.02545
NLRP2B NLR family pyrin domain containing 2B -2.0184
EIF4H eukaryotic translation initiation factor 4H -2.0139
NCAPD2 non-SMC condensin I complex, subunit D2 -2.00785
NCS1 neuronal calcium sensor 1 -2.0069
ZNF557 zinc finger protein 557 -2.00265
SLC10A3 solute carrier family 10, member 3 -2.0013
SAP30BP SAP30 binding protein -2.0011