CRCGN017_MCF10A.WT.HP_24H:L21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclosporin-a 10.87 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

310 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 9.07375
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 7.2852
GFPT1 glutamine--fructose-6-phosphate transaminase 1 7.22148
AGR2 anterior gradient 2 6.5402
GLRX glutaredoxin (thioltransferase) 6.3754
PYCR1 pyrroline-5-carboxylate reductase 1 5.249
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.22013
SLC35B1 solute carrier family 35, member B1 5.20925
AARS1 alanyl-tRNA synthetase 1 5.16435
ZW10 zw10 kinetochore protein 5.1129
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.9743
PHGDH phosphoglycerate dehydrogenase 4.8261
C2CD2 C2 calcium-dependent domain containing 2 4.66875
TRIB3 tribbles pseudokinase 3 4.3173
RPN1 ribophorin I 4.20695
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 3.9309
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 3.92255
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.8402
LOC128125814 uncharacterized LOC128125814 3.77925
NLRP4 NLR family, pyrin domain containing 4 3.7162
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.61115
PSAT1 phosphoserine aminotransferase 1 3.6069
CNRIP1 cannabinoid receptor interacting protein 1 3.5985
GARS1 glycyl-tRNA synthetase 1 3.59535
ACAA1 acetyl-CoA acyltransferase 1 3.56728
WFS1 Wolfram syndrome 1 (wolframin) 3.5463
TMEM39A transmembrane protein 39A 3.53695
ASNS asparagine synthetase (glutamine-hydrolyzing) 3.4835
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 3.40235
SQSTM1 sequestosome 1 3.39565
SSR4 signal sequence receptor, delta 3.3196
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 3.2165
ATF4 activating transcription factor 4 3.15215
TMEM214 transmembrane protein 214 3.1401
GMPPA GDP-mannose pyrophosphorylase A 3.07965
SLC67A1 solute carrier family 67 member 1 3.0759
CARS1 cysteinyl-tRNA synthetase 1 3.07562
PGM3 phosphoglucomutase 3 3.06652
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.03205
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 3.02107
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.00185
XPOT exportin, tRNA 2.99575
ARCN1 archain 1 2.98215
NARS1 asparaginyl-tRNA synthetase 1 2.9799
RBKS ribokinase 2.92852
UFM1 ubiquitin-fold modifier 1 2.9213
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.85735
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 2.8497
MANF mesencephalic astrocyte-derived neurotrophic factor 2.8026
ERP29 endoplasmic reticulum protein 29 2.79995
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.796
UGDH UDP-glucose 6-dehydrogenase 2.776
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2.76955
SNX17 sorting nexin 17 2.74705
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 2.72848
EGR1 early growth response 1 2.68812
ATRAID all-trans retinoic acid-induced differentiation factor 2.67755
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.6713
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.6591
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.64878
HAX1 HCLS1 associated protein X-1 2.6477
COPB1 coatomer protein complex, subunit beta 1 2.64493
ECH1 enoyl CoA hydratase 1, peroxisomal 2.64475
PRAF2 PRA1 domain family, member 2 2.6332
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.6314
LOXL1 lysyl oxidase-like 1 2.612
NRBF2 nuclear receptor binding factor 2 2.6012
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.59865
ACOT8 acyl-CoA thioesterase 8 2.59685
TMEM260 transmembrane protein 260 2.59395
IFRD1 interferon-related developmental regulator 1 2.5899
VSIG2 V-set and immunoglobulin domain containing 2 2.5796
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 2.5784
ZNF410 zinc finger protein 410 2.55825
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 2.55405
TRAPPC12 trafficking protein particle complex 12 2.5437
SARAF store-operated calcium entry-associated regulatory factor 2.5366
CXCL2 chemokine (C-X-C motif) ligand 2 2.53055
SH3YL1 SH3 and SYLF domain containing 1 2.5299
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.51825
SARS1 seryl-tRNA synthetase 1 2.5131
P3H1 prolyl 3-hydroxylase 1 2.5108
CALU calumenin 2.49258
FICD FIC domain containing 2.48585
ARF4 ADP-ribosylation factor 4 2.46625
YARS1 tyrosyl-tRNA synthetase 1 2.46105
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 2.4431
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.44293
SIL1 SIL1 nucleotide exchange factor 2.43275
WIF1 WNT inhibitory factor 1 2.42295
HDLBP high density lipoprotein binding protein 2.41692
CHPF chondroitin polymerizing factor 2.40795
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.4015
AKTIP AKT interacting protein 2.39825
EEIG1 estrogen-induced osteoclastogenesis regulator 1 2.38875
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.37905
USO1 USO1 vesicle transport factor 2.36895
FNDC4 fibronectin type III domain containing 4 2.364
COPG1 coatomer protein complex, subunit gamma 1 2.3405
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.33965
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.33205
MAGED1 melanoma antigen family D1 2.3169
ANXA6 annexin A6 2.31395
BABAM2 BRISC and BRCA1 A complex member 2 2.3088
PDIA6 protein disulfide isomerase family A, member 6 2.30405
IARS1 isoleucyl-tRNA synthetase 1 2.30295
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.3023
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.2846
SNX19 sorting nexin 19 2.2589
MORC4 MORC family CW-type zinc finger 4 2.24265
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.23997
HMOX1 heme oxygenase 1 2.2393
FOXO4 forkhead box O4 2.239
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.2342
SCCPDH saccharopine dehydrogenase (putative) 2.23058
GLT8D1 glycosyltransferase 8 domain containing 1 2.2092
MAGED2 melanoma antigen family D2 2.20598
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.20585
GABARAP GABA(A) receptor-associated protein 2.20035
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 2.19607
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.19245
NUPR1 nuclear protein, transcriptional regulator, 1 2.18785
MOSPD2 motile sperm domain containing 2 2.17497
USP48 ubiquitin specific peptidase 48 2.16835
SEC31A SEC31 homolog A (S. cerevisiae) 2.15807
GOLGB1 golgin B1 2.15363
SLC38A10 solute carrier family 38, member 10 2.14925
JTB jumping translocation breakpoint 2.14867
CZIB CXXC motif containing zinc binding protein 2.1476
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.1372
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 2.12965
NPIPB5 nuclear pore complex interacting protein family, member B5 2.1244
MSTO1 misato 1, mitochondrial distribution and morphology regulator 2.11985
MINDY1 MINDY lysine 48 deubiquitinase 1 2.1194
RABAC1 Rab acceptor 1 (prenylated) 2.11715
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 2.1015
UFL1 UFM1-specific ligase 1 2.08997
FYN FYN proto-oncogene, Src family tyrosine kinase 2.08248
GOLGA3 golgin A3 2.08245
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 2.07585
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.0631
MYDGF myeloid-derived growth factor 2.06043
SERP1 stress-associated endoplasmic reticulum protein 1 2.05613
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.05565
TSKU tsukushi, small leucine rich proteoglycan 2.0537
EIF2D eukaryotic translation initiation factor 2D 2.05015
PABPC1 poly(A) binding protein, cytoplasmic 1 2.0367
TMED7 transmembrane emp24 protein transport domain containing 7 2.03597
MSRA methionine sulfoxide reductase A 2.03485
SPG11 spastic paraplegia 11 (autosomal recessive) 2.03135
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.0302
PAAF1 proteasomal ATPase-associated factor 1 2.02715
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.02445
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.02338
SRPRB signal recognition particle receptor, B subunit 2.0229
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 2.02017
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.01615
TERF2IP telomeric repeat binding factor 2, interacting protein 2.01585
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.00915
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.00225

decreased expression

Symbol Name Standardized Value
PFN1 profilin 1 -5.2698
SGK1 serum/glucocorticoid regulated kinase 1 -5.0
CAB39 calcium binding protein 39 -4.79395
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.73037
CDC45 cell division cycle 45 -4.5481
SMNDC1 survival motor neuron domain containing 1 -4.2662
DCK deoxycytidine kinase -4.0958
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.42659
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.40805
DYNLT3 dynein, light chain, Tctex-type 3 -3.3796
TUBB6 tubulin, beta 6 class V -3.2784
NCS1 neuronal calcium sensor 1 -3.09175
ELAC2 elaC ribonuclease Z 2 -3.0806
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -3.0183
BACE2 beta-site APP-cleaving enzyme 2 -3.01035
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.9686
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -2.93038
TRIP13 thyroid hormone receptor interactor 13 -2.92395
NUP153 nucleoporin 153kDa -2.9221
CD320 CD320 molecule -2.9149
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 -2.91395
KRT14 keratin 14, type I -2.9064
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -2.89065
QSER1 glutamine and serine rich 1 -2.83725
TK1 thymidine kinase 1, soluble -2.7848
WDR76 WD repeat domain 76 -2.7562
IL18 interleukin 18 -2.7332
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.69345
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.68855
ADRM1 adhesion regulating molecule 1 -2.68345
NUP93 nucleoporin 93kDa -2.64375
LMTK2 lemur tyrosine kinase 2 -2.6171
RFC3 replication factor C (activator 1) 3, 38kDa -2.60755
CTBP2 C-terminal binding protein 2 -2.5692
NUP85 nucleoporin 85kDa -2.56285
MRPS17 mitochondrial ribosomal protein S17 -2.56015
HPS6 Hermansky-Pudlak syndrome 6 -2.55455
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.54745
ICE1 interactor of little elongation complex ELL subunit 1 -2.5059
STMN1 stathmin 1 -2.50005
PPID peptidylprolyl isomerase D -2.48637
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.48445
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.4774
PCNA proliferating cell nuclear antigen -2.4361
MED28 mediator complex subunit 28 -2.431
TMEM109 transmembrane protein 109 -2.4219
PFAS phosphoribosylformylglycinamidine synthase -2.4209
YJU2 YJU2 splicing factor homolog -2.3991
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.3946
MCM3 minichromosome maintenance complex component 3 -2.3941
KIF18A kinesin family member 18A -2.3818
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.37705
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.372
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.36125
TMEM132A transmembrane protein 132A -2.35155
MRPL44 mitochondrial ribosomal protein L44 -2.338
ELOVL6 ELOVL fatty acid elongase 6 -2.3377
ADRB2 adrenoceptor beta 2, surface -2.32535
NUP160 nucleoporin 160kDa -2.3189
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -2.3162
KLK8 kallikrein-related peptidase 8 -2.3151
FFAR2 free fatty acid receptor 2 -2.3082
FBXO3 F-box protein 3 -2.3057
RBBP5 retinoblastoma binding protein 5 -2.29925
SAFB scaffold attachment factor B -2.29733
ASF1B anti-silencing function 1B histone chaperone -2.29005
MAP7D3 MAP7 domain containing 3 -2.28457
BASP1 brain abundant, membrane attached signal protein 1 -2.2836
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.27345
TGIF2 TGFB-induced factor homeobox 2 -2.26772
HEYL hes-related family bHLH transcription factor with YRPW motif-like -2.26655
SOX18 SRY (sex determining region Y)-box 18 -2.25985
CENPM centromere protein M -2.25905
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.2501
NRTN neurturin -2.248
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.2451
E4F1 E4F transcription factor 1 -2.24225
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -2.23175
BCCIP BRCA2 and CDKN1A interacting protein -2.23005
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.22705
TMEM177 transmembrane protein 177 -2.2189
GTF2A1 general transcription factor IIA, 1, 19/37kDa -2.2177
GFRA3 GDNF family receptor alpha 3 -2.2157
ADGRB1 adhesion G protein-coupled receptor B1 -2.2137
FANCA Fanconi anemia, complementation group A -2.21068
LIFR leukemia inhibitory factor receptor alpha -2.20195
PODXL2 podocalyxin-like 2 -2.2
PRR15L proline rich 15-like -2.19965
GJA8 gap junction protein, alpha 8, 50kDa -2.1972
WRAP53 WD repeat containing, antisense to TP53 -2.1972
HSPB1 heat shock 27kDa protein 1 -2.19305
MCMBP minichromosome maintenance complex binding protein -2.1847
BTBD1 BTB (POZ) domain containing 1 -2.18295
CCDC86 coiled-coil domain containing 86 -2.1823
FAAP24 FA core complex associated protein 24 -2.16015
ZNF586 zinc finger protein 586 -2.1567
ABHD11 abhydrolase domain containing 11 -2.155
IREB2 iron-responsive element binding protein 2 -2.1532
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.1532
MAP1S microtubule-associated protein 1S -2.14845
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -2.14768
TCF20 transcription factor 20 (AR1) -2.14235
ADAMDEC1 ADAM-like, decysin 1 -2.14205
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.13145
CMKLR1 chemerin chemokine-like receptor 1 -2.1286
SMAD9 SMAD family member 9 -2.12675
EXD3 exonuclease 3'-5' domain containing 3 -2.1227
CD81 CD81 molecule -2.12015
TMEM160 transmembrane protein 160 -2.1191
SMAD6 SMAD family member 6 -2.11538
HAT1 histone acetyltransferase 1 -2.114
MGA MGA, MAX dimerization protein -2.1069
CDC6 cell division cycle 6 -2.1066
ERCC6L excision repair cross-complementation group 6-like -2.1002
FEV FEV (ETS oncogene family) -2.0997
TNIP3 TNFAIP3 interacting protein 3 -2.0919
MAP7D1 MAP7 domain containing 1 -2.09115
MAB21L1 mab-21-like 1 (C. elegans) -2.0835
ZNF318 zinc finger protein 318 -2.0829
THOC6 THO complex 6 -2.0795
PDE7B phosphodiesterase 7B -2.07775
STIMATE STIM activating enhancer -2.0727
ZNF124 zinc finger protein 124 -2.07205
SOCS1 suppressor of cytokine signaling 1 -2.07057
CCNA2 cyclin A2 -2.06785
CDK2 cyclin-dependent kinase 2 -2.06728
S100A8 S100 calcium binding protein A8 -2.06395
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.06065
LOC124900193 uncharacterized LOC124900193 -2.05915
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) -2.05368
PCDHB13 protocadherin beta 13 -2.05285
RASIP1 Ras interacting protein 1 -2.0504
S100A5 S100 calcium binding protein A5 -2.04765
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.04745
WDR4 WD repeat domain 4 -2.0425
NCAPD2 non-SMC condensin I complex, subunit D2 -2.0406
EXOSC4 exosome component 4 -2.03318
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -2.02605
MT2A metallothionein 2A -2.026
WNT7B wingless-type MMTV integration site family, member 7B -2.02355
ARHGAP11A Rho GTPase activating protein 11A -2.0198
PPP4C protein phosphatase 4, catalytic subunit -2.0186
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.0148
ATAD3A ATPase family, AAA domain containing 3A -2.01245
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F -2.01068
OXSR1 oxidative stress responsive 1 -2.01005
FGF8 fibroblast growth factor 8 (androgen-induced) -2.00795
DSN1 DSN1, MIS12 kinetochore complex component -2.00495
A4GALT alpha 1,4-galactosyltransferase -2.0028
TBCCD1 TBCC domain containing 1 -2.0003