CRCGN017_MCF10A.WT.HP_24H:M01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzofuran 102.79 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

287 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RAP1GAP RAP1 GTPase activating protein 5.86641
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.61795
NOSIP nitric oxide synthase interacting protein 4.51264
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.35204
WIF1 WNT inhibitory factor 1 4.06836
KDM5A lysine (K)-specific demethylase 5A 3.58439
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.47636
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 3.1272
HOXC5 homeobox C5 2.96087
CHAMP1 chromosome alignment maintaining phosphoprotein 1 2.95966
ZNF589 zinc finger protein 589 2.92109
CPE carboxypeptidase E 2.8815
PRR7 proline rich 7 (synaptic) 2.83193
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.76334
GCG glucagon 2.72014
NEUROD1 neuronal differentiation 1 2.71803
DNASE1 deoxyribonuclease I 2.71548
REG3A regenerating islet-derived 3 alpha 2.71122
HOXC4 homeobox C4 2.69689
CCNJ cyclin J 2.63469
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.5831
LAP3 leucine aminopeptidase 3 2.5786
RSBN1 round spermatid basic protein 1 2.57751
CIAO3 cytosolic iron-sulfur assembly component 3 2.57511
PDE4B phosphodiesterase 4B, cAMP-specific 2.56958
SERHL2 serine hydrolase-like 2 2.56294
ZNF74 zinc finger protein 74 2.5309
TEDC2 tubulin epsilon and delta complex 2 2.53081
ZBTB5 zinc finger and BTB domain containing 5 2.526
KRT24 keratin 24, type I 2.52243
RBM12B RNA binding motif protein 12B 2.51591
ZFP30 ZFP30 zinc finger protein 2.51244
ZNF423 zinc finger protein 423 2.49997
RBM15B RNA binding motif protein 15B 2.49111
CPA1 carboxypeptidase A1 (pancreatic) 2.4791
NRTN neurturin 2.47039
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.45095
IAPP islet amyloid polypeptide 2.44787
CERK ceramide kinase 2.43916
CRELD2 cysteine-rich with EGF-like domains 2 2.43738
HPS4 Hermansky-Pudlak syndrome 4 2.43564
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.43097
TERT telomerase reverse transcriptase 2.4146
H1-3 H1.3 linker histone, cluster member 2.40817
PPOX protoporphyrinogen oxidase 2.40455
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 2.40108
FGF14 fibroblast growth factor 14 2.40106
ZNF318 zinc finger protein 318 2.39004
EIF3L eukaryotic translation initiation factor 3, subunit L 2.3885
PGLYRP1 peptidoglycan recognition protein 1 2.36831
REG1B regenerating islet-derived 1 beta 2.36663
YJU2 YJU2 splicing factor homolog 2.3631
GAN gigaxonin 2.35798
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.35597
PHEX phosphate regulating endopeptidase homolog, X-linked 2.35539
TBC1D31 TBC1 domain family, member 31 2.35304
CPA2 carboxypeptidase A2 (pancreatic) 2.35213
TREML2 triggering receptor expressed on myeloid cells-like 2 2.35085
HYOU1 hypoxia up-regulated 1 2.34898
DSCC1 DNA replication and sister chromatid cohesion 1 2.344
LZTR1 leucine-zipper-like transcription regulator 1 2.33845
TCTN1 tectonic family member 1 2.33738
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.33359
SGSM3 small G protein signaling modulator 3 2.33274
TBC1D15 TBC1 domain family, member 15 2.32989
INSM1 insulinoma-associated 1 2.3292
GPR27 G protein-coupled receptor 27 2.32835
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.3208
DEFA5 defensin, alpha 5, Paneth cell-specific 2.31931
TXLNG taxilin gamma 2.31051
CLCNKB chloride channel, voltage-sensitive Kb 2.29672
PAQR3 progestin and adipoQ receptor family member III 2.29126
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 2.28835
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.28526
PLPP6 phospholipid phosphatase 6 2.28121
RNF19B ring finger protein 19B 2.27918
FAM76A family with sequence similarity 76, member A 2.2789
SP4 Sp4 transcription factor 2.27824
KIF22 kinesin family member 22 2.27463
ARHGAP4 Rho GTPase activating protein 4 2.27191
ARHGAP5 Rho GTPase activating protein 5 2.27158
MKS1 Meckel syndrome, type 1 2.26751
SIRT6 sirtuin 6 2.25827
FSD1 fibronectin type III and SPRY domain containing 1 2.25564
CELA2A chymotrypsin-like elastase family, member 2A 2.25529
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.24769
PELI1 pellino E3 ubiquitin protein ligase 1 2.24547
H2BC21 H2B clustered histone 21 2.24091
MEP1B meprin A, beta 2.2337
AUNIP aurora kinase A and ninein interacting protein 2.22765
NSD1 nuclear receptor binding SET domain protein 1 2.22636
C5 complement component 5 2.22486
CAPN9 calpain 9 2.22054
TCF20 transcription factor 20 (AR1) 2.21998
SAPCD1 suppressor APC domain containing 1 2.21964
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 2.21797
POLK polymerase (DNA directed) kappa 2.21479
TRIB1 tribbles pseudokinase 1 2.21204
STK10 serine/threonine kinase 10 2.20985
ABI3BP ABI family, member 3 (NESH) binding protein 2.20885
DLK2 delta-like 2 homolog (Drosophila) 2.20438
DPT dermatopontin 2.19674
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.18345
HIPK1 homeodomain interacting protein kinase 1 2.1822
SCG3 secretogranin III 2.18076
DRAM1 DNA-damage regulated autophagy modulator 1 2.1761
TCP10L t-complex 10-like 2.1739
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 2.17345
INS insulin 2.1716
TAS2R4 taste receptor, type 2, member 4 2.16823
ZNF835 zinc finger protein 835 2.16653
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2.16375
CUZD1 CUB and zona pellucida-like domains 1 2.16118
H2BC3 H2B clustered histone 3 2.1606
PRKX protein kinase, X-linked 2.15761
MMP2 matrix metallopeptidase 2 2.15625
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 2.15542
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.15466
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.1519
DEFA4 defensin, alpha 4, corticostatin 2.15146
EML1 echinoderm microtubule associated protein like 1 2.14954
SESN1 sestrin 1 2.14737
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.14449
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.14321
BCL7A B-cell CLL/lymphoma 7A 2.13818
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 2.13745
ZNF493 zinc finger protein 493 2.13728
DOT1L DOT1-like histone H3K79 methyltransferase 2.13414
PRSS22 protease, serine, 22 2.13102
WASHC5 WASH complex subunit 5 2.13087
H2BC9 H2B clustered histone 9 2.12524
ADORA2A adenosine A2a receptor 2.11897
TMC5 transmembrane channel-like 5 2.11615
PPP4C protein phosphatase 4, catalytic subunit 2.11082
THAP7 THAP domain containing 7 2.10734
ALDOB aldolase B, fructose-bisphosphate 2.10681
RXRG retinoid X receptor, gamma 2.10652
H2AC4 H2A clustered histone 4 2.10286
MNS1 meiosis-specific nuclear structural 1 2.09991
UNC13B unc-13 homolog B (C. elegans) 2.09847
ZNF696 zinc finger protein 696 2.0932
JADE3 jade family PHD finger 3 2.08817
KATNIP katanin interacting protein 2.08815
CD200 CD200 molecule 2.08723
CD72 CD72 molecule 2.08475
PLA2G1B phospholipase A2, group IB (pancreas) 2.0823
AP1AR adaptor-related protein complex 1 associated regulatory protein 2.08068
GALR3 galanin receptor 3 2.07974
ARRB2 arrestin, beta 2 2.07851
CCL2 chemokine (C-C motif) ligand 2 2.07777
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 2.0758
TLL1 tolloid-like 1 2.07564
DGCR6L DiGeorge syndrome critical region gene 6-like 2.07446
CDHR5 cadherin-related family member 5 2.07408
EREG epiregulin 2.07395
TRABD TraB domain containing 2.07134
GRPR gastrin-releasing peptide receptor 2.07021
KIF18B kinesin family member 18B 2.0673
SIRPA signal-regulatory protein alpha 2.06497
CYRIA CYFIP related Rac1 interactor A 2.06189
HLX H2.0-like homeobox 2.05633
GSTA1 glutathione S-transferase alpha 1 2.05622
ELSPBP1 epididymal sperm binding protein 1 2.05278
NANOS2 nanos homolog 2 (Drosophila) 2.05078
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 2.04916
DNAI7 dynein axonemal intermediate chain 7 2.04879
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.04747
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.04743
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 2.03583
CNTFR ciliary neurotrophic factor receptor 2.03142
CCHCR1 coiled-coil alpha-helical rod protein 1 2.03033
CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough 2.02922
FUBP1 far upstream element (FUSE) binding protein 1 2.02825
IFT54 intraflagellar transport 54 2.02699
CADM1 cell adhesion molecule 1 2.0261
CTBP2 C-terminal binding protein 2 2.0235
CFAP44 cilia and flagella associated protein 44 2.02267
CCNO cyclin O 2.02243
CAV1 caveolin 1, caveolae protein, 22kDa 2.02237
MECP2 methyl CpG binding protein 2 2.02045
CHRM4 cholinergic receptor, muscarinic 4 2.01925
CAV2 caveolin 2 2.01894
PRDM12 PR domain containing 12 2.01831
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 2.01744
RORB RAR-related orphan receptor B 2.01494
CD2AP CD2-associated protein 2.01462
KREMEN2 kringle containing transmembrane protein 2 2.01322
MTRF1L mitochondrial translational release factor 1-like 2.01293
MGAM maltase-glucoamylase 2.01216
ZNF507 zinc finger protein 507 2.01203
GRM6 glutamate receptor, metabotropic 6 2.01011
TRAIP TRAF interacting protein 2.01003
SORCS3 sortilin-related VPS10 domain containing receptor 3 2.01
BLNK B-cell linker 2.00935
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 2.0077
TAS2R1 taste receptor, type 2, member 1 2.0073
MUC6 mucin 6, oligomeric mucus/gel-forming 2.00661
CDADC1 cytidine and dCMP deaminase domain containing 1 2.00386
TSPAN2 tetraspanin 2 2.00225

decreased expression

Symbol Name Standardized Value
SLC25A46 solute carrier family 25, member 46 -6.05335
BAG3 BCL2-associated athanogene 3 -5.34845
CYCS cytochrome c, somatic -5.09112
NUP85 nucleoporin 85kDa -4.9168
TXNDC9 thioredoxin domain containing 9 -4.78652
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.79294
MRPL58 mitochondrial ribosomal protein L58 -3.63747
MSN moesin -3.62752
PHKA1 phosphorylase kinase, alpha 1 (muscle) -3.62468
MRPS7 mitochondrial ribosomal protein S7 -3.53567
ISOC1 isochorismatase domain containing 1 -3.38679
JPT1 Jupiter microtubule associated homolog 1 -3.13588
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -2.99062
NUSAP1 nucleolar and spindle associated protein 1 -2.78117
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.61663
SORBS3 sorbin and SH3 domain containing 3 -2.58977
CBR3 carbonyl reductase 3 -2.53416
UFM1 ubiquitin-fold modifier 1 -2.52578
GIPC1 GIPC PDZ domain containing family, member 1 -2.5231
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -2.5165
CCDC86 coiled-coil domain containing 86 -2.51069
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa -2.5014
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.48989
ACAA1 acetyl-CoA acyltransferase 1 -2.48076
KRCC1 lysine-rich coiled-coil 1 -2.45877
CASC3 cancer susceptibility candidate 3 -2.4471
GGCT gamma-glutamylcyclotransferase -2.43264
TRAPPC12 trafficking protein particle complex 12 -2.41885
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.40612
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.35414
MLEC malectin -2.34741
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.32474
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -2.32225
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.31775
ZNF443 zinc finger protein 443 -2.30792
PDCD10 programmed cell death 10 -2.29609
S100A2 S100 calcium binding protein A2 -2.29027
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.28937
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.27382
ILK integrin-linked kinase -2.27089
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.26629
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -2.26134
EIF4A3 eukaryotic translation initiation factor 4A3 -2.26066
RRAGA Ras-related GTP binding A -2.26023
MRPL17 mitochondrial ribosomal protein L17 -2.23996
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.23506
SH3D19 SH3 domain containing 19 -2.23475
OSTF1 osteoclast stimulating factor 1 -2.22828
SASH3 SAM and SH3 domain containing 3 -2.21396
CTR9 CTR9, Paf1/RNA polymerase II complex component -2.21104
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.20911
RBKS ribokinase -2.20882
BAD BCL2-associated agonist of cell death -2.20522
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor -2.20302
MLH1 mutL homolog 1 -2.19494
REPS2 RALBP1 associated Eps domain containing 2 -2.17207
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.16913
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -2.16534
BCL7B B-cell CLL/lymphoma 7B -2.16229
TMEM94 transmembrane protein 94 -2.15548
DPP3 dipeptidyl-peptidase 3 -2.14445
SCYL3 SCY1-like 3 (S. cerevisiae) -2.13474
NAV3 neuron navigator 3 -2.13193
CDC20 cell division cycle 20 -2.13143
MAGED1 melanoma antigen family D1 -2.13004
NT5C 5', 3'-nucleotidase, cytosolic -2.12607
COG4 component of oligomeric golgi complex 4 -2.12598
KCTD2 potassium channel tetramerization domain containing 2 -2.12414
TUBG2 tubulin, gamma 2 -2.12371
LBHD1 LBH domain containing 1 -2.12079
KMT5B lysine methyltransferase 5B -2.10529
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.10174
EMC7 ER membrane protein complex subunit 7 -2.09267
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.091
TALDO1 transaldolase 1 -2.08361
SNX17 sorting nexin 17 -2.07338
SUMF2 sulfatase modifying factor 2 -2.06916
NRIP3 nuclear receptor interacting protein 3 -2.06461
RWDD1 RWD domain containing 1 -2.06391
XPO7 exportin 7 -2.04469
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -2.03272
AACS acetoacetyl-CoA synthetase -2.0301
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -2.02742
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.01979
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -2.01876
ANXA5 annexin A5 -2.01397
METTL18 methyltransferase like 18 -2.01383
PHKB phosphorylase kinase, beta -2.00478