CRCGN017_MCF10A.WT.HP_24H:M08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlordane 33.27 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.8194
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.68615
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 3.4511
PLS1 plastin 1 3.3218
PXMP2 peroxisomal membrane protein 2, 22kDa 3.24373
NLRP4 NLR family, pyrin domain containing 4 3.05375
HBB hemoglobin, beta 2.93513
RAB31 RAB31, member RAS oncogene family 2.72475
PRDX4 peroxiredoxin 4 2.5539
PRR7 proline rich 7 (synaptic) 2.368
ASXL2 additional sex combs like transcriptional regulator 2 2.3058
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 2.2136
LRRC20 leucine rich repeat containing 20 2.1245
STARD13 StAR-related lipid transfer (START) domain containing 13 2.08555

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -6.89735
DSG2 desmoglein 2 -5.07955
PCCB propionyl CoA carboxylase, beta polypeptide -4.87355
HMG20B high mobility group 20B -4.83273
PCNA proliferating cell nuclear antigen -4.81085
CCNB1 cyclin B1 -4.72615
DNM1L dynamin 1-like -4.6995
CAB39 calcium binding protein 39 -4.2888
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.9677
TRAPPC3 trafficking protein particle complex 3 -3.60698
CRNKL1 crooked neck pre-mRNA splicing factor 1 -3.12
ARID4B AT rich interactive domain 4B (RBP1-like) -3.09865
MT2A metallothionein 2A -3.0085
MT1X metallothionein 1X -3.00725
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.93682
ACAA1 acetyl-CoA acyltransferase 1 -2.75353
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.71222
MRPS15 mitochondrial ribosomal protein S15 -2.6329
WASHC4 WASH complex subunit 4 -2.51447
DDRGK1 DDRGK domain containing 1 -2.45655
ZNF350 zinc finger protein 350 -2.432
SQSTM1 sequestosome 1 -2.4007
MSMO1 methylsterol monooxygenase 1 -2.3316
PANK2 pantothenate kinase 2 -2.3024
EFS embryonal Fyn-associated substrate -2.2962
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -2.2593
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.25565
NSFL1C NSFL1 (p97) cofactor (p47) -2.2504
MKKS McKusick-Kaufman syndrome -2.2287
APMAP adipocyte plasma membrane associated protein -2.13195
ZNF112 zinc finger protein 112 -2.1283
MSN moesin -2.1175
CD9 CD9 molecule -2.0925
SGK1 serum/glucocorticoid regulated kinase 1 -2.08925
CAPRIN2 caprin family member 2 -2.08905
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.08305
RESF1 retroelement silencing factor 1 -2.0714
FNBP1L formin binding protein 1-like -2.0673
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.04405
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -2.0316
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.0166
CSRP1 cysteine and glycine-rich protein 1 -2.00827