CRCGN017_MCF10A.WT.HP_24H:M10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description styrene 98.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

77 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.0511
ABHD4 abhydrolase domain containing 4 5.11145
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.04205
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.8878
ACAA1 acetyl-CoA acyltransferase 1 3.27457
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.8727
DTX2 deltex 2, E3 ubiquitin ligase 2.65455
GPC1 glypican 1 2.49288
AGR2 anterior gradient 2 2.42385
FYN FYN proto-oncogene, Src family tyrosine kinase 2.33698
SPDEF SAM pointed domain containing ETS transcription factor 2.32493
INTS3 integrator complex subunit 3 2.2849
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.25835
NCOA6 nuclear receptor coactivator 6 2.24675
POMK protein-O-mannose kinase 2.2293
MEX3C mex-3 RNA binding family member C 2.2175
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.21735
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.2095
ACOT8 acyl-CoA thioesterase 8 2.20805
TGFBR1 transforming growth factor, beta receptor 1 2.15395
ACP6 acid phosphatase 6, lysophosphatidic 2.14095
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.1174
STEAP3 STEAP family member 3, metalloreductase 2.10805
NRBF2 nuclear receptor binding factor 2 2.0844
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.0726
AKAP8 A kinase (PRKA) anchor protein 8 2.0636
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 2.05722
CFAP20 cilia and flagella associated protein 20 2.05345
SPRY2 sprouty homolog 2 (Drosophila) 2.04445
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.0159
PABPC3 poly(A) binding protein, cytoplasmic 3 2.0158

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -9.55755
MRPS2 mitochondrial ribosomal protein S2 -5.327
UFM1 ubiquitin-fold modifier 1 -5.042
LAP3 leucine aminopeptidase 3 -4.9528
NPDC1 neural proliferation, differentiation and control, 1 -4.34225
TUBB6 tubulin, beta 6 class V -4.3055
MT2A metallothionein 2A -4.1289
GDF15 growth differentiation factor 15 -3.9254
S100A8 S100 calcium binding protein A8 -3.84495
BASP1 brain abundant, membrane attached signal protein 1 -3.77525
MTFR1 mitochondrial fission regulator 1 -3.6613
PFN1 profilin 1 -3.53335
PPP1R26 protein phosphatase 1, regulatory subunit 26 -3.4371
TRIB3 tribbles pseudokinase 3 -3.09035
MT1X metallothionein 1X -3.08745
PAEP progestagen-associated endometrial protein -3.07885
KRT14 keratin 14, type I -3.00555
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.93725
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.75505
ARID4B AT rich interactive domain 4B (RBP1-like) -2.73945
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.5563
MED15 mediator complex subunit 15 -2.5529
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.4864
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -2.38945
DUSP14 dual specificity phosphatase 14 -2.37535
WASHC4 WASH complex subunit 4 -2.36937
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.35575
FOS FBJ murine osteosarcoma viral oncogene homolog -2.3185
HAUS3 HAUS augmin-like complex, subunit 3 -2.2893
LRRC40 leucine rich repeat containing 40 -2.2074
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.20255
EMID1 EMI domain containing 1 -2.18355
KANK1 KN motif and ankyrin repeat domains 1 -2.16335
MRPS31 mitochondrial ribosomal protein S31 -2.1545
OBP2B odorant binding protein 2B -2.11165
CD2AP CD2-associated protein -2.1015
DENND4B DENN/MADD domain containing 4B -2.0761
ENPEP glutamyl aminopeptidase (aminopeptidase A) -2.07342
BCL2L13 BCL2-like 13 (apoptosis facilitator) -2.07255
PLA2G12A phospholipase A2, group XIIA -2.062
FAM193A family with sequence similarity 193, member A -2.05365
OBP2A odorant binding protein 2A -2.04625
TSC1 tuberous sclerosis 1 -2.0449
CCNJ cyclin J -2.0346
PTCD2 pentatricopeptide repeat domain 2 -2.02755
SOX9 SRY (sex determining region Y)-box 9 -2.027