CRCGN017_MCF10A.WT.HP_24H:M11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description styrene 32.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

86 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.36075
GTPBP8 GTP-binding protein 8 (putative) 3.2982
LYN LYN proto-oncogene, Src family tyrosine kinase 3.25798
PRKCQ protein kinase C, theta 3.24023
RAB27A RAB27A, member RAS oncogene family 3.18775
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 3.16975
COQ8A coenzyme Q8A 2.8212
SYK spleen tyrosine kinase 2.74547
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.71025
SLC75A1 solute carrier family 75 member 1 2.6963
COL4A5 collagen, type IV, alpha 5 2.5737
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 2.55325
C5 complement component 5 2.5369
DPP6 dipeptidyl-peptidase 6 2.53245
CCL2 chemokine (C-C motif) ligand 2 2.424
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.3981
IFT52 intraflagellar transport 52 2.382
S100A7 S100 calcium binding protein A7 2.34995
ZNF516 zinc finger protein 516 2.33495
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 2.3118
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.2725
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.27055
SINHCAF SIN3-HDAC complex associated factor 2.26755
SOX2 SRY (sex determining region Y)-box 2 2.2478
METRN meteorin, glial cell differentiation regulator 2.239
ATG7 autophagy related 7 2.218
NOL4 nucleolar protein 4 2.20465
DENND2D DENN/MADD domain containing 2D 2.20385
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.20215
SYT17 synaptotagmin XVII 2.1665
ACTG2 actin, gamma 2, smooth muscle, enteric 2.16415
APOE apolipoprotein E 2.15953
SATB1 SATB homeobox 1 2.15645
TOPBP1 topoisomerase (DNA) II binding protein 1 2.14995
DOCK2 dedicator of cytokinesis 2 2.14235
FGL1 fibrinogen-like 1 2.13175
NOSIP nitric oxide synthase interacting protein 2.1198
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.11387
GATA3 GATA binding protein 3 2.10877
PADI1 peptidyl arginine deiminase, type I 2.10865
TERT telomerase reverse transcriptase 2.1059
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.09645
LGMN legumain 2.08615
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.0664
CD302 CD302 molecule 2.04465
GCA grancalcin, EF-hand calcium binding protein 2.03975
HAMP hepcidin antimicrobial peptide 2.0316
CPM carboxypeptidase M 2.027
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.0224
MNS1 meiosis-specific nuclear structural 1 2.02105
NT5DC3 5'-nucleotidase domain containing 3 2.01865
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.0153
EPCIP exosomal polycystin 1 interacting protein 2.01015

decreased expression

Symbol Name Standardized Value
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.10715
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0
HMG20B high mobility group 20B -4.67088
COPS7A COP9 signalosome subunit 7A -4.0521
MSN moesin -3.85625
NGRN neugrin, neurite outgrowth associated -3.2082
CD58 CD58 molecule -3.0233
MTERF3 mitochondrial transcription termination factor 3 -2.99895
FPGS folylpolyglutamate synthase -2.951
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.89007
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.68035
CAB39 calcium binding protein 39 -2.61585
TLCD3A TLC domain containing 3A -2.4457
SMIM10L1 small integral membrane protein 10 like 1 -2.33235
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.3206
RBM34 RNA binding motif protein 34 -2.29355
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.2455
GNPAT glyceronephosphate O-acyltransferase -2.2447
TMEM115 transmembrane protein 115 -2.23595
FOXJ2 forkhead box J2 -2.14265
IFRD2 interferon-related developmental regulator 2 -2.11678
FBXO7 F-box protein 7 -2.116
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.06795
KRT14 keratin 14, type I -2.06565
YY1AP1 YY1 associated protein 1 -2.0595
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.04525
GGPS1 geranylgeranyl diphosphate synthase 1 -2.03612
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.0322
CUL1 cullin 1 -2.02955
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.02445
GTF2H5 general transcription factor IIH, polypeptide 5 -2.0197
GARS1 glycyl-tRNA synthetase 1 -2.01705
PRRX2 paired related homeobox 2 -2.0046