| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole 99.95 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
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122 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 7.123 |
| HMOX1 | heme oxygenase 1 | 7.0921 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 4.90685 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 4.70565 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 4.54295 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 4.53495 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 4.03398 |
| SESN1 | sestrin 1 | 3.59865 |
| SQOR | sulfide quinone oxidoreductase | 3.3744 |
| TICAM1 | toll-like receptor adaptor molecule 1 | 3.33455 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 3.2318 |
| WIF1 | WNT inhibitory factor 1 | 3.1662 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 3.0238 |
| GLRX | glutaredoxin (thioltransferase) | 2.96312 |
| SQSTM1 | sequestosome 1 | 2.93005 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 2.9239 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.84065 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.67515 |
| CBR1 | carbonyl reductase 1 | 2.6728 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 2.49195 |
| GSR | glutathione reductase | 2.4519 |
| MRPL18 | mitochondrial ribosomal protein L18 | 2.44905 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 2.44733 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 2.40878 |
| ABHD4 | abhydrolase domain containing 4 | 2.40095 |
| STAP2 | signal transducing adaptor family member 2 | 2.39735 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.3679 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.34385 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 2.29945 |
| UBQLN2 | ubiquilin 2 | 2.27835 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 2.26375 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 2.24495 |
| METRN | meteorin, glial cell differentiation regulator | 2.23215 |
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | 2.2157 |
| RAB5IF | RAB5 interacting factor | 2.1759 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.16595 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 2.1368 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 2.1335 |
| ASF1A | anti-silencing function 1A histone chaperone | 2.125 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 2.1233 |
| SDHC | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 2.12304 |
| GTF2H5 | general transcription factor IIH, polypeptide 5 | 2.1021 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | 2.09945 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 2.0847 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 2.07065 |
| FHOD1 | formin homology 2 domain containing 1 | 2.0652 |
| DUSP4 | dual specificity phosphatase 4 | 2.05487 |
| NDUFAF3 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 | 2.04955 |
| HPS5 | Hermansky-Pudlak syndrome 5 | 2.041 |
| TSPAN13 | tetraspanin 13 | 2.03545 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 2.0321 |
| DUSP5 | dual specificity phosphatase 5 | 2.0172 |
| KLHL21 | kelch-like family member 21 | 2.01535 |
| TMEM248 | transmembrane protein 248 | 2.0019 |
| NPC1 | Niemann-Pick disease, type C1 | 2.0005 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC20 | cell division cycle 20 | -5.60365 |
| RPIA | ribose 5-phosphate isomerase A | -5.39665 |
| HSPA8 | heat shock 70kDa protein 8 | -5.01528 |
| NUP85 | nucleoporin 85kDa | -4.54995 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -4.2841 |
| CCNB2 | cyclin B2 | -4.15865 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -4.09713 |
| STMN1 | stathmin 1 | -4.09445 |
| CDC45 | cell division cycle 45 | -3.55935 |
| BAD | BCL2-associated agonist of cell death | -3.35892 |
| WASHC4 | WASH complex subunit 4 | -3.16088 |
| ANKRD10 | ankyrin repeat domain 10 | -3.1027 |
| NRIP1 | nuclear receptor interacting protein 1 | -3.00898 |
| IFRD2 | interferon-related developmental regulator 2 | -2.9615 |
| SNX7 | sorting nexin 7 | -2.94545 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -2.91313 |
| KIF15 | kinesin family member 15 | -2.8755 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.85945 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.8292 |
| ZNF318 | zinc finger protein 318 | -2.81635 |
| KIF20A | kinesin family member 20A | -2.78825 |
| CD81 | CD81 molecule | -2.66495 |
| KIF11 | kinesin family member 11 | -2.65355 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.64245 |
| KIF18A | kinesin family member 18A | -2.57365 |
| SLC16A5 | solute carrier family 16 (monocarboxylate transporter), member 5 | -2.49275 |
| MRPS7 | mitochondrial ribosomal protein S7 | -2.4894 |
| PCDHGA5 | protocadherin gamma subfamily A, 5 | -2.47965 |
| CKMT2 | creatine kinase, mitochondrial 2 (sarcomeric) | -2.41205 |
| TRAIP | TRAF interacting protein | -2.40305 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -2.4006 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -2.374 |
| ZNF112 | zinc finger protein 112 | -2.36525 |
| HROB | homologous recombination factor with OB-fold | -2.31585 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -2.30455 |
| ACSM1 | acyl-CoA synthetase medium-chain family member 1 | -2.29325 |
| TUBA3E | tubulin, alpha 3e | -2.2782 |
| FILIP1L | filamin A interacting protein 1-like | -2.2776 |
| AURKB | aurora kinase B | -2.26625 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -2.25585 |
| SUMO4 | small ubiquitin-like modifier 4 | -2.24755 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -2.2218 |
| DPF1 | D4, zinc and double PHD fingers family 1 | -2.19695 |
| KLHDC2 | kelch domain containing 2 | -2.1963 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -2.1736 |
| MRPL58 | mitochondrial ribosomal protein L58 | -2.1698 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.16445 |
| CEP72 | centrosomal protein 72kDa | -2.12975 |
| KLHL29 | kelch-like family member 29 | -2.1286 |
| CDC25C | cell division cycle 25C | -2.12448 |
| MYBPC2 | myosin binding protein C, fast type | -2.10475 |
| ARHGAP11A | Rho GTPase activating protein 11A | -2.0993 |
| TMEM39B | transmembrane protein 39B | -2.09315 |
| NUP107 | nucleoporin 107kDa | -2.08745 |
| HOXA2 | homeobox A2 | -2.08505 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | -2.0801 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | -2.06995 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -2.05442 |
| PCYOX1 | prenylcysteine oxidase 1 | -2.0308 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -2.02955 |
| NXF3 | nuclear RNA export factor 3 | -2.024 |
| RNASE6 | ribonuclease, RNase A family, k6 | -2.0134 |
| ACADL | acyl-CoA dehydrogenase, long chain | -2.0113 |
| HOXA5 | homeobox A5 | -2.00565 |
| MB | myoglobin | -2.00545 |
| ZBED5 | zinc finger, BED-type containing 5 | -2.004 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -2.00195 |
