CRCGN017_MCF10A.WT.HP_24H:M14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole 33.32 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.50435
STK10 serine/threonine kinase 10 5.13363
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.9059
CXCR4 chemokine (C-X-C motif) receptor 4 4.52972
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.09035
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.97685
HBA1 hemoglobin, alpha 1 3.56159
ACAA1 acetyl-CoA acyltransferase 1 3.34355
HBB hemoglobin, beta 3.08628
TPGS1 tubulin polyglutamylase complex subunit 1 3.03295
GRB10 growth factor receptor-bound protein 10 2.99555
VAV3 vav 3 guanine nucleotide exchange factor 2.83042
GPS1 G protein pathway suppressor 1 2.81285
ACLY ATP citrate lyase 2.73545
SNX11 sorting nexin 11 2.69705
PRPF8 pre-mRNA processing factor 8 2.64895
TIAM1 T-cell lymphoma invasion and metastasis 1 2.62605
VAMP5 vesicle-associated membrane protein 5 2.4854
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 2.24905
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.19533
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.1553
CNRIP1 cannabinoid receptor interacting protein 1 2.14535
TSPYL5 TSPY-like 5 2.09235
APH1A APH1A gamma secretase subunit 2.08935
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 2.06445
DYNLT1 dynein, light chain, Tctex-type 1 2.05815
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.05025
HMOX1 heme oxygenase 1 2.0403
ACTN4 actinin, alpha 4 2.03195
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.02835
AKTIP AKT interacting protein 2.0179
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 2.0165
MOGAT1 monoacylglycerol O-acyltransferase 1 2.01515
DHCR7 7-dehydrocholesterol reductase 2.00275

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.7928
HSPA8 heat shock 70kDa protein 8 -5.36278
PCCB propionyl CoA carboxylase, beta polypeptide -5.3127
HAT1 histone acetyltransferase 1 -5.1192
HMG20B high mobility group 20B -5.00003
TRAPPC3 trafficking protein particle complex 3 -4.9861
VDAC1 voltage-dependent anion channel 1 -4.40037
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.73275
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.66093
ETFB electron-transfer-flavoprotein, beta polypeptide -3.5911
KIF20A kinesin family member 20A -3.47975
SGK1 serum/glucocorticoid regulated kinase 1 -3.3785
GLB1L2 galactosidase, beta 1-like 2 -3.04195
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.84608
PSRC1 proline/serine-rich coiled-coil 1 -2.6739
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.5466
ADGRL1 adhesion G protein-coupled receptor L1 -2.51345
MRPS15 mitochondrial ribosomal protein S15 -2.38455
CNMD chondromodulin -2.36165
EIF3L eukaryotic translation initiation factor 3, subunit L -2.31475
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.28752
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.2664
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.24895
LAX1 lymphocyte transmembrane adaptor 1 -2.18245
MFSD12 major facilitator superfamily domain containing 12 -2.17652
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.15457
BSG basigin (Ok blood group) -2.14375
KRT14 keratin 14, type I -2.14355
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.13915
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.13517
SYTL3 synaptotagmin-like 3 -2.1325
CDK1 cyclin-dependent kinase 1 -2.10777
GPC3 glypican 3 -2.1036
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.09165
RNASE6 ribonuclease, RNase A family, k6 -2.0794
CD1C CD1c molecule -2.07385
ASPHD1 aspartate beta-hydroxylase domain containing 1 -2.06435
CD1E CD1e molecule -2.06333
ZFYVE26 zinc finger, FYVE domain containing 26 -2.06087
ANKRD10 ankyrin repeat domain 10 -2.0574
SIK2 salt-inducible kinase 2 -2.0441
MRPS31 mitochondrial ribosomal protein S31 -2.03597
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.02445
TTLL1 tubulin tyrosine ligase-like family member 1 -2.01715
METTL9 methyltransferase like 9 -2.01645