CRCGN017_MCF10A.WT.HP_24H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-amino-5-(5-nitro-2-furyl)-1,3,4-oxadiazole 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.04135
CNRIP1 cannabinoid receptor interacting protein 1 4.8666
STK10 serine/threonine kinase 10 4.66815
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.66275
ABHD4 abhydrolase domain containing 4 4.57405
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.56575
FZD7 frizzled class receptor 7 4.46577
NNT nicotinamide nucleotide transhydrogenase 4.16603
RPP38 ribonuclease P/MRP 38kDa subunit 3.7992
ACAA1 acetyl-CoA acyltransferase 1 3.5747
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.17357
METRN meteorin, glial cell differentiation regulator 3.0009
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.82693
IGHMBP2 immunoglobulin mu binding protein 2 2.82298
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 2.48615
SATB1 SATB homeobox 1 2.39055
PTK7 protein tyrosine kinase 7 (inactive) 2.28935
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.2783
GSDMD gasdermin D 2.2479
CLIC3 chloride intracellular channel 3 2.2279
FIP1L1 factor interacting with PAPOLA and CPSF1 2.20645
HBA1 hemoglobin, alpha 1 2.20217
PRR15L proline rich 15-like 2.1862
MATN4 matrilin 4 2.16405
CCNA1 cyclin A1 2.16395
EVL Enah/Vasp-like 2.1571
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.142
HBB hemoglobin, beta 2.08822
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.0492
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.03533
ZNF84 zinc finger protein 84 2.02995
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.0

decreased expression

Symbol Name Standardized Value
RPIA ribose 5-phosphate isomerase A -9.0656
GDF15 growth differentiation factor 15 -6.7563
BAG3 BCL2-associated athanogene 3 -5.5875
COG2 component of oligomeric golgi complex 2 -5.09135
GLRX glutaredoxin (thioltransferase) -5.05653
S100A8 S100 calcium binding protein A8 -5.0
UFM1 ubiquitin-fold modifier 1 -4.9863
VAT1 vesicle amine transport 1 -4.91265
UBE3C ubiquitin protein ligase E3C -4.87945
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.12455
HMG20B high mobility group 20B -4.09347
SNX7 sorting nexin 7 -4.06325
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.82635
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.34075
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.03077
HSPA1A heat shock 70kDa protein 1A -2.9302
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.79205
RAD51C RAD51 paralog C -2.7706
ATF6 activating transcription factor 6 -2.58717
DCLK1 doublecortin-like kinase 1 -2.52208
RHOBTB1 Rho-related BTB domain containing 1 -2.44145
PROSER1 proline and serine rich 1 -2.3974
PLA1A phospholipase A1 member A -2.33565
MRPS31 mitochondrial ribosomal protein S31 -2.33542
QPCT glutaminyl-peptide cyclotransferase -2.2747
GSTT1 glutathione S-transferase theta 1 -2.26665
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.20015
DUSP4 dual specificity phosphatase 4 -2.18445
ALX1 ALX homeobox 1 -2.1712
KRT1 keratin 1, type II -2.1636
ASB9 ankyrin repeat and SOCS box containing 9 -2.04795