CRCGN017_MCF10A.WT.HP_24H:M19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description penicillin-v-potassium 100.91 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 8.99575
SPAG4 sperm associated antigen 4 5.38535
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 5.36795
CNRIP1 cannabinoid receptor interacting protein 1 5.13215
ABHD4 abhydrolase domain containing 4 4.64345
ADAM10 ADAM metallopeptidase domain 10 4.51808
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.3604
HBB hemoglobin, beta 4.18192
MTA2 metastasis associated 1 family, member 2 4.08225
NUTF2 nuclear transport factor 2 4.06715
WIF1 WNT inhibitory factor 1 4.0633
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 4.0559
RBBP5 retinoblastoma binding protein 5 3.82205
HBA1 hemoglobin, alpha 1 3.59334
THRAP3 thyroid hormone receptor associated protein 3 3.4964
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 3.25705
CEPT1 choline/ethanolamine phosphotransferase 1 3.07015
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.9607
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.9544
OSTF1 osteoclast stimulating factor 1 2.94475
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.80495
MDM4 MDM4, p53 regulator 2.79635
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.78715
IFI6 interferon, alpha-inducible protein 6 2.70655
KAT6B K(lysine) acetyltransferase 6B 2.58722
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.51887
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.4268
AGPS alkylglycerone phosphate synthase 2.3985
ADRB2 adrenoceptor beta 2, surface 2.36635
SRSF6 serine/arginine-rich splicing factor 6 2.33728
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 2.31875
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.3127
HP1BP3 heterochromatin protein 1, binding protein 3 2.29805
TLK1 tousled-like kinase 1 2.27725
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.24925
PRPF39 pre-mRNA processing factor 39 2.22565
GSR glutathione reductase 2.1714
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.1506
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 2.11755
ARF6 ADP-ribosylation factor 6 2.10605
RAB3D RAB3D, member RAS oncogene family 2.09665
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.08805
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.0818
RPL39 ribosomal protein L39 2.0759
RPL34 ribosomal protein L34 2.0708
MED18 mediator complex subunit 18 2.05805
WDR76 WD repeat domain 76 2.0532
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2.03515
ZNF652 zinc finger protein 652 2.0344

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.6203
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.1776
CCNB1 cyclin B1 -4.93985
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.2417
BASP1 brain abundant, membrane attached signal protein 1 -2.98695
KIF20A kinesin family member 20A -2.9757
SGK1 serum/glucocorticoid regulated kinase 1 -2.8453
OAT ornithine aminotransferase -2.78465
XPO7 exportin 7 -2.77335
SNX7 sorting nexin 7 -2.63965
CLK3 CDC-like kinase 3 -2.5891
ACAA1 acetyl-CoA acyltransferase 1 -2.5301
RAI14 retinoic acid induced 14 -2.3563
WASHC4 WASH complex subunit 4 -2.219
TMCC2 transmembrane and coiled-coil domain family 2 -2.1973
EXOC3 exocyst complex component 3 -2.19635
TLCD3A TLC domain containing 3A -2.19465
ELMO1 engulfment and cell motility 1 -2.1546
MINDY1 MINDY lysine 48 deubiquitinase 1 -2.13905
CDHR2 cadherin-related family member 2 -2.05365
ZSCAN5A zinc finger and SCAN domain containing 5A -2.0534
WRN Werner syndrome, RecQ helicase-like -2.05065
SLC66A2 solute carrier family 66 member 2 -2.019
YY1AP1 YY1 associated protein 1 -2.0018
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -2.00135