CRCGN017_MCF10A.WT.HP_24H:M20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description penicillin-v-potassium 33.64 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.1113
SNAP25 synaptosomal-associated protein, 25kDa 4.91415
WIF1 WNT inhibitory factor 1 4.79375
RPP38 ribonuclease P/MRP 38kDa subunit 3.7402
AXIN1 axin 1 3.3195
NOSIP nitric oxide synthase interacting protein 2.9565
RFX5 regulatory factor X, 5 (influences HLA class II expression) 2.8242
MCUR1 mitochondrial calcium uniporter regulator 1 2.51385
CCDC85B coiled-coil domain containing 85B 2.5106
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.24435
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.10255

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -5.28015
COG2 component of oligomeric golgi complex 2 -5.14875
SGK1 serum/glucocorticoid regulated kinase 1 -4.80235
TSPAN4 tetraspanin 4 -4.79358
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.6524
ANKRD10 ankyrin repeat domain 10 -2.90545
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.7197
CSRP1 cysteine and glycine-rich protein 1 -2.70288
SNX7 sorting nexin 7 -2.3704
WASHC4 WASH complex subunit 4 -2.34152
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -2.33755
EXOSC10 exosome component 10 -2.2998
WDR46 WD repeat domain 46 -2.2886
GBP2 guanylate binding protein 2, interferon-inducible -2.2767
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -2.27255
AADAC arylacetamide deacetylase -2.18075
CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough -2.1031
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.0679
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.05475
IL4R interleukin 4 receptor -2.0324