CRCGN017_MCF10A.WT.HP_24H:M22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 103.32 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 4.97246
CORO1A coronin, actin binding protein, 1A 4.7174
HMOX1 heme oxygenase 1 4.19765
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.142
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.9279
HBB hemoglobin, beta 3.6437
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.3944
ACAA1 acetyl-CoA acyltransferase 1 3.32915
OXSR1 oxidative stress responsive 1 3.04415
ZNF589 zinc finger protein 589 3.02042
UGDH UDP-glucose 6-dehydrogenase 2.8746
KDM5A lysine (K)-specific demethylase 5A 2.78673
MYOZ3 myozenin 3 2.68095
GET1 guided entry of tail-anchored proteins factor 1 2.5125
ZNF26 zinc finger protein 26 2.43145
CERK ceramide kinase 2.408
LMO7 LIM domain 7 2.40385
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.36485
TBPL1 TBP-like 1 2.34655
SYNPO2L synaptopodin 2-like 2.3315
MYOZ2 myozenin 2 2.29167
COMP cartilage oligomeric matrix protein 2.2724
PDZRN3 PDZ domain containing ring finger 3 2.2656
AQP9 aquaporin 9 2.24575
SCD5 stearoyl-CoA desaturase 5 2.2082
ART3 ADP-ribosyltransferase 3 2.20815
KLHL41 kelch-like family member 41 2.2039
PYGM phosphorylase, glycogen, muscle 2.19325
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.15845
MYOT myotilin 2.14985
POLR1G RNA polymerase I subunit G 2.14385
CD48 CD48 molecule 2.12985
RHOBTB1 Rho-related BTB domain containing 1 2.1158
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.11335
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.10855
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.0949
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.0879
TRDN triadin 2.08725
APOB apolipoprotein B 2.08595
PRKX protein kinase, X-linked 2.08177
PLSCR1 phospholipid scramblase 1 2.07865
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 2.07105
SMPX small muscle protein, X-linked 2.0651
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.06275
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.05845
GTPBP8 GTP-binding protein 8 (putative) 2.05185
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.04747
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.0448
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.04295
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 2.03135
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.02387
ALAS1 5'-aminolevulinate synthase 1 2.0228
NTAQ1 N-terminal glutamine amidase 1 2.0193
TRAPPC6A trafficking protein particle complex 6A 2.01795
ZNF22 zinc finger protein 22 2.0063
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.00578
PTX3 pentraxin 3, long 2.00455

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -5.55245
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.17295
MT2A metallothionein 2A -4.89535
PCNA proliferating cell nuclear antigen -4.75895
KIF14 kinesin family member 14 -4.74795
COG7 component of oligomeric golgi complex 7 -3.68045
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.4998
STXBP2 syntaxin binding protein 2 -3.38395
KRT14 keratin 14, type I -2.98565
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.98257
ARID4B AT rich interactive domain 4B (RBP1-like) -2.94755
HOXA5 homeobox A5 -2.93365
DDRGK1 DDRGK domain containing 1 -2.8381
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.7445
XPO7 exportin 7 -2.63133
ELP3 elongator acetyltransferase complex subunit 3 -2.60065
ANKFY1 ankyrin repeat and FYVE domain containing 1 -2.5338
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.47455
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.4665
SGK1 serum/glucocorticoid regulated kinase 1 -2.4639
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.4568
GDE1 glycerophosphodiester phosphodiesterase 1 -2.4406
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.4368
PRAF2 PRA1 domain family, member 2 -2.414
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.38142
RRAGA Ras-related GTP binding A -2.2658
TMEM230 transmembrane protein 230 -2.25435
LOC112694756 uncharaterized LOC112694756 -2.22832
ANKRD10 ankyrin repeat domain 10 -2.1088
RPA3 replication protein A3, 14kDa -2.10235
AGBL5 ATP/GTP binding protein-like 5 -2.10185
ANO10 anoctamin 10 -2.0816
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase -2.0743
TM9SF4 transmembrane 9 superfamily protein member 4 -2.06485
MT1X metallothionein 1X -2.05335
CLIP2 CAP-GLY domain containing linker protein 2 -2.0495
GDF15 growth differentiation factor 15 -2.0295
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.02945