| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 34.44 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
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62 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 5.29165 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 4.96355 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 4.9291 |
| CCDC92 | coiled-coil domain containing 92 | 4.77345 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 4.2206 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | 4.1118 |
| PRKCH | protein kinase C, eta | 3.68513 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 3.5928 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.5108 |
| NARS2 | asparaginyl-tRNA synthetase 2, mitochondrial (putative) | 3.41915 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 3.13745 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 2.9465 |
| ADRB2 | adrenoceptor beta 2, surface | 2.82015 |
| CCDC85B | coiled-coil domain containing 85B | 2.7386 |
| PKN1 | protein kinase N1 | 2.71762 |
| THAP12 | THAP domain containing 12 | 2.64855 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | 2.57095 |
| GPATCH8 | G patch domain containing 8 | 2.42365 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 2.3558 |
| FADD | Fas (TNFRSF6)-associated via death domain | 2.3523 |
| MOK | MOK protein kinase | 2.3476 |
| SAC3D1 | SAC3 domain containing 1 | 2.29535 |
| MEMO1 | mediator of cell motility 1 | 2.28825 |
| RSF1 | remodeling and spacing factor 1 | 2.10925 |
| UPK1B | uroplakin 1B | 2.10578 |
| INTS5 | integrator complex subunit 5 | 2.1001 |
| BPIFA1 | BPI fold containing family A, member 1 | 2.0683 |
| PRELID3A | PRELI domain containing 3A | 2.0641 |
| BSPRY | B-box and SPRY domain containing | 2.05395 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 2.0271 |
| TNIK | TRAF2 and NCK interacting kinase | 2.01643 |
| ATP5PO | ATP synthase peripheral stalk subunit OSCP | 2.00455 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.32815 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -5.18815 |
| GDF15 | growth differentiation factor 15 | -5.00525 |
| UFM1 | ubiquitin-fold modifier 1 | -4.7979 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -4.57242 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -4.47565 |
| COG2 | component of oligomeric golgi complex 2 | -4.33765 |
| MPC2 | mitochondrial pyruvate carrier 2 | -4.1889 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -3.94845 |
| MSMO1 | methylsterol monooxygenase 1 | -3.88605 |
| CLTB | clathrin, light chain B | -3.88071 |
| VDAC1 | voltage-dependent anion channel 1 | -3.79655 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -3.32028 |
| HEATR1 | HEAT repeat containing 1 | -3.27255 |
| ANKRD10 | ankyrin repeat domain 10 | -3.12025 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -2.54492 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | -2.43085 |
| BAD | BCL2-associated agonist of cell death | -2.41685 |
| NLGN4X | neuroligin 4, X-linked | -2.3214 |
| DEFB1 | defensin, beta 1 | -2.2942 |
| WDR91 | WD repeat domain 91 | -2.2625 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -2.21335 |
| PLTP | phospholipid transfer protein | -2.19105 |
| CDK11A | cyclin-dependent kinase 11A | -2.17455 |
| PFN1 | profilin 1 | -2.1439 |
| RCL1 | RNA terminal phosphate cyclase-like 1 | -2.11865 |
| MYBPC1 | myosin binding protein C, slow type | -2.0612 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -2.0499 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | -2.00285 |
| NCSTN | nicastrin | -2.00185 |
