| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (3s,16r,17s)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-16-carbonitrile 11.48 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
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66 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:M24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 4.384 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | 4.09925 |
| CNPY3 | canopy FGF signaling regulator 3 | 4.0868 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 3.5974 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 3.33695 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.0733 |
| UGDH | UDP-glucose 6-dehydrogenase | 3.0461 |
| MIS18A | MIS18 kinetochore protein A | 2.8589 |
| PTX3 | pentraxin 3, long | 2.74485 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 2.6876 |
| WDR18 | WD repeat domain 18 | 2.6027 |
| FBXO11 | F-box protein 11 | 2.59818 |
| ERAL1 | Era-like 12S mitochondrial rRNA chaperone 1 | 2.4671 |
| TRAF4 | TNF receptor-associated factor 4 | 2.44845 |
| APH1A | APH1A gamma secretase subunit | 2.403 |
| NTHL1 | nth endonuclease III-like 1 (E. coli) | 2.39975 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 2.3776 |
| MFAP2 | microfibrillar-associated protein 2 | 2.31105 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 2.3071 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 2.2947 |
| PRR7 | proline rich 7 (synaptic) | 2.2872 |
| FCHO1 | FCH domain only 1 | 2.22845 |
| FLOT2 | flotillin 2 | 2.22113 |
| SIX2 | SIX homeobox 2 | 2.21933 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 2.2055 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 2.14578 |
| SPAG5 | sperm associated antigen 5 | 2.12255 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | 2.10975 |
| METTL16 | methyltransferase like 16 | 2.1074 |
| LOC102724594 | splicing factor U2AF 35 kDa subunit | 2.07565 |
| CORO7-PAM16 | CORO7-PAM16 readthrough | 2.07325 |
| RHOG | ras homolog family member G | 2.073 |
| SIX1 | SIX homeobox 1 | 2.03415 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PCNA | proliferating cell nuclear antigen | -4.75895 |
| NUP85 | nucleoporin 85kDa | -4.24295 |
| CD44 | CD44 molecule (Indian blood group) | -3.99154 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -3.90785 |
| NLRP4 | NLR family, pyrin domain containing 4 | -3.80625 |
| TSPAN4 | tetraspanin 4 | -3.7555 |
| GDF15 | growth differentiation factor 15 | -3.49485 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -3.1213 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -2.97075 |
| XPO7 | exportin 7 | -2.89773 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.84408 |
| SETBP1 | SET binding protein 1 | -2.83795 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -2.775 |
| MSN | moesin | -2.6606 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -2.64267 |
| MRPS7 | mitochondrial ribosomal protein S7 | -2.61545 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.58785 |
| ACE2 | angiotensin I converting enzyme 2 | -2.47468 |
| MRPL58 | mitochondrial ribosomal protein L58 | -2.3673 |
| VTI1B | vesicle transport through interaction with t-SNAREs 1B | -2.35695 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | -2.30182 |
| CSRP1 | cysteine and glycine-rich protein 1 | -2.28337 |
| COL4A1 | collagen, type IV, alpha 1 | -2.18068 |
| MPC2 | mitochondrial pyruvate carrier 2 | -2.15725 |
| SUMO4 | small ubiquitin-like modifier 4 | -2.14395 |
| EIF2B2 | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | -2.13365 |
| SAP30BP | SAP30 binding protein | -2.1077 |
| NSUN3 | NOP2/Sun domain family, member 3 | -2.0793 |
| TOMM70 | translocase of outer mitochondrial membrane 70 | -2.07465 |
| DIPK1A | divergent protein kinase domain 1A | -2.07015 |
| PANK2 | pantothenate kinase 2 | -2.06915 |
| VIM | vimentin | -2.0356 |
| ACOX1 | acyl-CoA oxidase 1, palmitoyl | -2.02975 |
