CRCGN017_MCF10A.WT.HP_24H:N04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 98.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:N04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.22673
CARMIL1 capping protein regulator and myosin 1 linker 1 4.55241
MAST2 microtubule associated serine/threonine kinase 2 4.14617
HMOX1 heme oxygenase 1 3.70155
SPAG4 sperm associated antigen 4 3.6433
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.54628
METRN meteorin, glial cell differentiation regulator 3.02185
USP6NL USP6 N-terminal like 2.9343
TATDN2 TatD DNase domain containing 2 2.82235
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.79011
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.66775
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.45732
VAV3 vav 3 guanine nucleotide exchange factor 2.4405
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.32398
HKDC1 hexokinase domain containing 1 2.22966
GPA33 glycoprotein A33 (transmembrane) 2.19625
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.18977
HOXA5 homeobox A5 2.16522
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.08071
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.07618
RNF11 ring finger protein 11 2.06461
PHACTR4 phosphatase and actin regulator 4 2.03167

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -7.06266
MAPK13 mitogen-activated protein kinase 13 -5.28747
PCNA proliferating cell nuclear antigen -5.16348
CHMP4B charged multivesicular body protein 4B -5.11138
HMG20B high mobility group 20B -4.84497
KIF14 kinesin family member 14 -3.85397
CD81 CD81 molecule -3.7167
MPC2 mitochondrial pyruvate carrier 2 -3.21141
TLCD3A TLC domain containing 3A -3.04584
C2CD5 C2 calcium-dependent domain containing 5 -2.96104
IGFBP7 insulin-like growth factor binding protein 7 -2.86926
MT2A metallothionein 2A -2.86759
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.7826
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -2.53045
SLIT2 slit homolog 2 (Drosophila) -2.49415
THAP11 THAP domain containing 11 -2.43977
CTNND1 catenin (cadherin-associated protein), delta 1 -2.42846
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.41678
PANK2 pantothenate kinase 2 -2.32363
APMAP adipocyte plasma membrane associated protein -2.32152
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.31457
IST1 increased sodium tolerance 1 homolog (yeast) -2.26281
MIS18BP1 MIS18 binding protein 1 -2.22835
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.15741
TASP1 taspase, threonine aspartase, 1 -2.14578
DDRGK1 DDRGK domain containing 1 -2.13898
SEC23B Sec23 homolog B (S. cerevisiae) -2.12652
CD320 CD320 molecule -2.09111
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -2.07319
PFN1 profilin 1 -2.02906
KIF15 kinesin family member 15 -2.02218