CRCGN017_MCF10A.WT.HP_24H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 32.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 4.68681
TBX2 T-box 2 4.26392
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.8774
ANO1 anoctamin 1, calcium activated chloride channel 3.68318
COMP cartilage oligomeric matrix protein 3.52937
CXCL2 chemokine (C-X-C motif) ligand 2 3.47773
WASF3 WAS protein family, member 3 3.47643
VAV3 vav 3 guanine nucleotide exchange factor 3.29393
ZW10 zw10 kinetochore protein 2.95495
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.83324
CNRIP1 cannabinoid receptor interacting protein 1 2.74416
CERK ceramide kinase 2.35201
METRN meteorin, glial cell differentiation regulator 2.31588
PKN1 protein kinase N1 2.29922
CCL2 chemokine (C-C motif) ligand 2 2.28625
AXIN1 axin 1 2.26864
MMP1 matrix metallopeptidase 1 2.18313
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.1546
TSPAN6 tetraspanin 6 2.10407
IL13RA1 interleukin 13 receptor, alpha 1 2.07121
GALK1 galactokinase 1 2.02062

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -5.0095
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.79975
MPC2 mitochondrial pyruvate carrier 2 -4.64414
RPIA ribose 5-phosphate isomerase A -3.62005
GDF15 growth differentiation factor 15 -3.32985
FASTKD5 FAST kinase domains 5 -3.0311
SCYL3 SCY1-like 3 (S. cerevisiae) -2.92458
ACAA1 acetyl-CoA acyltransferase 1 -2.86189
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.77714
COPS7A COP9 signalosome subunit 7A -2.7479
RNF167 ring finger protein 167 -2.03428