CRCGN017_MCF10A.WT.HP_24H:N06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethylbenzidine.2hcl 10.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:N06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.44125
AXIN1 axin 1 5.33225
CXCL2 chemokine (C-X-C motif) ligand 2 4.8204
PRKCQ protein kinase C, theta 3.5585
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.86035
HBB hemoglobin, beta 2.84102
CERK ceramide kinase 2.7484
GPATCH8 G patch domain containing 8 2.61777
BAX BCL2-associated X protein 2.60733
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.4296
CNPY3 canopy FGF signaling regulator 3 2.3276
CCL2 chemokine (C-C motif) ligand 2 2.2837
CXCL3 chemokine (C-X-C motif) ligand 3 2.17565
DENND2D DENN/MADD domain containing 2D 2.15875
FBXO11 F-box protein 11 2.15133
MUC16 mucin 16, cell surface associated 2.0084

decreased expression

Symbol Name Standardized Value
CDC25B cell division cycle 25B -5.1128
NPDC1 neural proliferation, differentiation and control, 1 -5.0
UBE3C ubiquitin protein ligase E3C -4.76605
HMG20B high mobility group 20B -3.96312
EXOSC4 exosome component 4 -3.69657
ARID4B AT rich interactive domain 4B (RBP1-like) -3.2999
TRAPPC3 trafficking protein particle complex 3 -3.0952
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.865
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.5564
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 -2.4069
STAT1 signal transducer and activator of transcription 1, 91kDa -2.17069
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.13975
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.05845
MSN moesin -2.0578
CD320 CD320 molecule -2.0411
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -2.0162
BASP1 brain abundant, membrane attached signal protein 1 -2.00375
FFAR2 free fatty acid receptor 2 -2.00015