CRCGN017_MCF10A.WT.HP_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethylbenzene 100.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 5.10325
GPER1 G protein-coupled estrogen receptor 1 4.7148
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.00555
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.58535
UGDH UDP-glucose 6-dehydrogenase 3.4259
GARRE1 granule associated Rac and RHOG effector 1 2.7562
NPIPA6 nuclear pore complex interacting protein family, member A6 2.3826
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.37435
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.34575
FBXO11 F-box protein 11 2.31525
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.29325
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.25812
TMEM176B transmembrane protein 176B 2.2224
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.1995
TMEM176A transmembrane protein 176A 2.18795
DCAF13 DDB1 and CUL4 associated factor 13 2.1276
OLFML2B olfactomedin-like 2B 2.0568
UBAC1 UBA domain containing 1 2.0462
WIF1 WNT inhibitory factor 1 2.0361
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.03327
TRAPPC6A trafficking protein particle complex 6A 2.0042

decreased expression

Symbol Name Standardized Value
DSG2 desmoglein 2 -10.0
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.33725
ECH1 enoyl CoA hydratase 1, peroxisomal -4.92035
BAG3 BCL2-associated athanogene 3 -4.90955
SNX7 sorting nexin 7 -4.4347
PMM2 phosphomannomutase 2 -4.12245
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.88578
HAT1 histone acetyltransferase 1 -3.69965
PHKA1 phosphorylase kinase, alpha 1 (muscle) -3.66095
STXBP2 syntaxin binding protein 2 -3.6504
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.60585
RPA3 replication protein A3, 14kDa -3.18285
MTERF3 mitochondrial transcription termination factor 3 -2.8702
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.70893
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.625
SLC35B1 solute carrier family 35, member B1 -2.27325
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.22785
SORBS3 sorbin and SH3 domain containing 3 -2.0145