CRCGN017_MCF10A.WT.HP_24H:N08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethylbenzene 33.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:N08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCNA1 cyclin A1 5.54775
LOXL1 lysyl oxidase-like 1 4.8677
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.75077
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.5083
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 4.44785
WIF1 WNT inhibitory factor 1 3.8596
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.7717
KLHL21 kelch-like family member 21 3.62425
CHEK1 checkpoint kinase 1 3.48347
HBB hemoglobin, beta 3.29705
WASF3 WAS protein family, member 3 3.2391
TBX2 T-box 2 3.13583
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.9712
USP6NL USP6 N-terminal like 2.88355
KDM5A lysine (K)-specific demethylase 5A 2.83695
MTA2 metastasis associated 1 family, member 2 2.7722
RBBP5 retinoblastoma binding protein 5 2.5851
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.5487
GSTK1 glutathione S-transferase kappa 1 2.39215
HBA1 hemoglobin, alpha 1 2.37707
LHFPL6 LHFPL tetraspan subfamily member 6 2.31095
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.28525
TRIM5 tripartite motif containing 5 2.2811
PLTP phospholipid transfer protein 2.2701
NUTF2 nuclear transport factor 2 2.15505
ZW10 zw10 kinetochore protein 2.1107
XKR8 XK, Kell blood group complex subunit-related family, member 8 2.0782
ZMIZ1 zinc finger, MIZ-type containing 1 2.06395

decreased expression

Symbol Name Standardized Value
PARP2 poly (ADP-ribose) polymerase 2 -4.93067
CCNB1 cyclin B1 -4.81075
HMG20B high mobility group 20B -4.69945
TLCD3A TLC domain containing 3A -4.60555
NLRP4 NLR family, pyrin domain containing 4 -3.26765
PLK1 polo-like kinase 1 -3.07505
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.98055
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.9455
GDF15 growth differentiation factor 15 -2.79415
NGRN neugrin, neurite outgrowth associated -2.74945
METTL17 methyltransferase like 17 -2.41325
RPA3 replication protein A3, 14kDa -2.3633
SORBS3 sorbin and SH3 domain containing 3 -2.24775
ADGRL3 adhesion G protein-coupled receptor L3 -2.13265
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -2.1306
FAM169A family with sequence similarity 169, member A -2.0403
BCHE butyrylcholinesterase -2.00425