CRCGN017_MCF10A.WT.HP_24H:N11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description griseofulvin 33.52 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

307 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:N11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
H2BC12 H2B clustered histone 12 5.885
STK10 serine/threonine kinase 10 5.70515
SSBP2 single-stranded DNA binding protein 2 5.30067
ADAM10 ADAM metallopeptidase domain 10 5.02855
NUP133 nucleoporin 133kDa 4.84375
HBA1 hemoglobin, alpha 1 4.55012
H2BC9 H2B clustered histone 9 4.11565
CDPF1 cysteine-rich, DPF motif domain containing 1 4.0543
CXCL2 chemokine (C-X-C motif) ligand 2 3.8757
IDE insulin-degrading enzyme 3.8497
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.838
GATA2 GATA binding protein 2 3.77822
H2BC5 H2B clustered histone 5 3.52375
HBB hemoglobin, beta 3.5184
H2BC4 H2B clustered histone 4 3.51577
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.49673
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 3.32827
PECR peroxisomal trans-2-enoyl-CoA reductase 3.32205
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 3.24398
TIGAR TP53 induced glycolysis regulatory phosphatase 3.17775
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.1262
SLC75A1 solute carrier family 75 member 1 3.1085
NOSIP nitric oxide synthase interacting protein 3.02825
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.98425
ADAT1 adenosine deaminase, tRNA-specific 1 2.96695
NPIPA6 nuclear pore complex interacting protein family, member A6 2.9615
H1-2 H1.2 linker histone, cluster member 2.95405
GATA3 GATA binding protein 3 2.9211
HYAL4 hyaluronoglucosaminidase 4 2.90105
LCE2B late cornified envelope 2B 2.86145
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 2.8543
TMCO1 transmembrane and coiled-coil domains 1 2.83122
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.8238
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.81975
S100A4 S100 calcium binding protein A4 2.7978
OXSR1 oxidative stress responsive 1 2.78695
SH2B3 SH2B adaptor protein 3 2.7677
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.7432
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.7407
MMP1 matrix metallopeptidase 1 2.72315
FCHO1 FCH domain only 1 2.7215
RGS2 regulator of G-protein signaling 2 2.72075
FOXO4 forkhead box O4 2.7106
H2AC6 H2A clustered histone 6 2.71055
CYB5R2 cytochrome b5 reductase 2 2.70455
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.69915
MYOD1 myogenic differentiation 1 2.6827
RAB3B RAB3B, member RAS oncogene family 2.67595
H2AC7 H2A clustered histone 7 2.6714
VLDLR very low density lipoprotein receptor 2.64235
MINDY2 MINDY lysine 48 deubiquitinase 2 2.61572
ZMAT3 zinc finger, matrin-type 3 2.61365
RAB31 RAB31, member RAS oncogene family 2.60082
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.599
SMIM41 small integral membrane protein 41 2.5981
TERF2IP telomeric repeat binding factor 2, interacting protein 2.54665
LYN LYN proto-oncogene, Src family tyrosine kinase 2.54392
CD83 CD83 molecule 2.52835
OSR2 odd-skipped related transciption factor 2 2.515
H2AC19 H2A clustered histone 19 2.51355
IER5 immediate early response 5 2.49925
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.4974
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.45925
TASOR2 transcription activation suppressor family member 2 2.44195
PRSS23 protease, serine, 23 2.41545
STIMATE STIM activating enhancer 2.41245
KPLCE KPRP N-terminal and LCE C-terminal like protein 2.41225
H2BC21 H2B clustered histone 21 2.4106
DLC1 DLC1 Rho GTPase activating protein 2.40914
CRELD2 cysteine-rich with EGF-like domains 2 2.3855
CCDC86 coiled-coil domain containing 86 2.3795
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.3711
EGLN1 egl-9 family hypoxia-inducible factor 1 2.35735
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.33815
PLAG1 pleiomorphic adenoma gene 1 2.33685
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.3311
HAL histidine ammonia-lyase 2.32807
CDSN corneodesmosin 2.32435
RBBP9 retinoblastoma binding protein 9 2.321
COL9A2 collagen, type IX, alpha 2 2.31345
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.30355
CGB8 chorionic gonadotropin, beta polypeptide 8 2.29875
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.29445
DUSP14 dual specificity phosphatase 14 2.29435
HLX H2.0-like homeobox 2.29395
SLC35B1 solute carrier family 35, member B1 2.2782
CEMIP2 cell migration inducing hyaluronidase 2 2.2778
CORO2B coronin, actin binding protein, 2B 2.26945
OXTR oxytocin receptor 2.26485
ZC3H15 zinc finger CCCH-type containing 15 2.2558
PTEN phosphatase and tensin homolog 2.25383
CBARP CACN subunit beta associated regulatory protein 2.2484
SSX3 synovial sarcoma, X breakpoint 3 2.24727
PALMD palmdelphin 2.2398
CPM carboxypeptidase M 2.22785
TICAM1 toll-like receptor adaptor molecule 1 2.22645
FERMT2 fermitin family member 2 2.2233
LORICRIN loricrin cornified envelope precursor protein 2.2229
UNC13A unc-13 homolog A (C. elegans) 2.22245
LOC124906748 beta-defensin 4A 2.22235
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.2211
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.21615
FZD4 frizzled class receptor 4 2.209
ISG15 ISG15 ubiquitin-like modifier 2.19765
CAPN9 calpain 9 2.19738
FAT1 FAT atypical cadherin 1 2.19335
ALOXE3 arachidonate lipoxygenase 3 2.19117
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 2.1887
ZNF155 zinc finger protein 155 2.1837
ADAP2 ArfGAP with dual PH domains 2 2.1807
KRT9 keratin 9, type I 2.1781
H2BC3 H2B clustered histone 3 2.17775
OPN1MW3 opsin 1, medium wave sensitive 3 2.1715
DCAF13 DDB1 and CUL4 associated factor 13 2.16995
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.16965
RECK reversion-inducing-cysteine-rich protein with kazal motifs 2.16755
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 2.16705
MEIS1 Meis homeobox 1 2.15875
CDH5 cadherin 5, type 2 (vascular endothelium) 2.1578
MTCH1 mitochondrial carrier 1 2.13585
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 2.1328
CXCR4 chemokine (C-X-C motif) receptor 4 2.1307
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 2.1259
PCDH12 protocadherin 12 2.12575
UFSP2 UFM1-specific peptidase 2 2.12495
SPI1 Spi-1 proto-oncogene 2.1233
GHR growth hormone receptor 2.1215
METTL22 methyltransferase like 22 2.1213
SIM1 single-minded family bHLH transcription factor 1 2.1207
EXD3 exonuclease 3'-5' domain containing 3 2.12055
HEMK2 HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine 2.105
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.10295
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.10135
VSX1 visual system homeobox 1 2.10055
SQLE squalene epoxidase 2.09973
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.09483
KRT2 keratin 2, type II 2.08875
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.08605
CTSG cathepsin G 2.07805
RBMS1 RNA binding motif, single stranded interacting protein 1 2.07422
BEX4 brain expressed, X-linked 4 2.07095
CLCN1 chloride channel, voltage-sensitive 1 2.0645
KTN1 kinectin 1 (kinesin receptor) 2.06447
SPAG16 sperm associated antigen 16 2.062
LRRC32 leucine rich repeat containing 32 2.0601
TMEM184C transmembrane protein 184C 2.0576
LOC107985101 uncharacterized LOC107985101 2.048
FAM107A family with sequence similarity 107, member A 2.04665
PYCARD PYD and CARD domain containing 2.0461
FLG filaggrin 2.04515
SPEG SPEG complex locus 2.0451
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 2.0432
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) 2.0337
RFTN1 raftlin, lipid raft linker 1 2.0325
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 2.02835
ZFP36 ZFP36 ring finger protein 2.0262
CNPY4 canopy FGF signaling regulator 4 2.0243
FSHB follicle stimulating hormone, beta polypeptide 2.02045
NECAP1 NECAP endocytosis associated 1 2.01805
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) 2.01712
COL4A5 collagen, type IV, alpha 5 2.01415
ADRM1 adhesion regulating molecule 1 2.00775
BCAS2 breast carcinoma amplified sequence 2 2.00685
TBC1D31 TBC1 domain family, member 31 2.0034
PRKCQ protein kinase C, theta 2.0027
ARHGAP29 Rho GTPase activating protein 29 2.00075

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -7.56
ADI1 acireductone dioxygenase 1 -6.8307
KRT14 keratin 14, type I -5.98945
HMG20B high mobility group 20B -5.87342
DCK deoxycytidine kinase -5.4505
SLC35F2 solute carrier family 35, member F2 -5.4092
NLRP4 NLR family, pyrin domain containing 4 -5.38055
HADH hydroxyacyl-CoA dehydrogenase -5.2125
TOP2A topoisomerase (DNA) II alpha 170kDa -5.04385
CCNB1 cyclin B1 -5.0
ETFB electron-transfer-flavoprotein, beta polypeptide -4.708
DSG2 desmoglein 2 -4.68205
CCNB2 cyclin B2 -4.48415
CDK1 cyclin-dependent kinase 1 -4.427
AURKB aurora kinase B -4.4153
ANKRD10 ankyrin repeat domain 10 -4.38525
GALE UDP-galactose-4-epimerase -4.2378
CD44 CD44 molecule (Indian blood group) -4.03494
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.57083
CIRBP cold inducible RNA binding protein -3.4307
GTF2IRD1 GTF2I repeat domain containing 1 -3.39885
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.39845
DDIT4 DNA-damage-inducible transcript 4 -3.337
CDCA4 cell division cycle associated 4 -3.3104
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.26775
MACROD1 MACRO domain containing 1 -3.26255
CDC45 cell division cycle 45 -3.21835
TP53 tumor protein p53 -3.18618
TTC19 tetratricopeptide repeat domain 19 -3.08535
CKAP2 cytoskeleton associated protein 2 -3.06855
COG4 component of oligomeric golgi complex 4 -3.05065
PLK1 polo-like kinase 1 -3.045
ASF1B anti-silencing function 1B histone chaperone -3.04265
RFC2 replication factor C (activator 1) 2, 40kDa -2.99585
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.9939
NUP93 nucleoporin 93kDa -2.96795
CDK4 cyclin-dependent kinase 4 -2.9573
PCCB propionyl CoA carboxylase, beta polypeptide -2.93565
RACGAP1 Rac GTPase activating protein 1 -2.92865
KIF11 kinesin family member 11 -2.9003
LOC112694756 uncharaterized LOC112694756 -2.8981
MKI67 marker of proliferation Ki-67 -2.82139
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.81405
FBXO5 F-box protein 5 -2.783
BLM Bloom syndrome, RecQ helicase-like -2.7429
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.70285
NUSAP1 nucleolar and spindle associated protein 1 -2.68675
BIRC5 baculoviral IAP repeat containing 5 -2.66248
CBR3 carbonyl reductase 3 -2.66115
CCNA2 cyclin A2 -2.66103
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -2.65205
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.6513
NCAPH non-SMC condensin I complex, subunit H -2.62915
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.60247
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.59275
PRC1 protein regulator of cytokinesis 1 -2.5793
ZDHHC6 zinc finger, DHHC-type containing 6 -2.5696
CENPA centromere protein A -2.5551
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.546
GFUS GDP-L-fucose synthase -2.54532
NUP85 nucleoporin 85kDa -2.54445
RUVBL1 RuvB-like AAA ATPase 1 -2.5271
CCL21 chemokine (C-C motif) ligand 21 -2.51345
TOR3A torsin family 3, member A -2.5121
POGK pogo transposable element with KRAB domain -2.5102
RBM47 RNA binding motif protein 47 -2.47735
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.47535
RLIM ring finger protein, LIM domain interacting -2.46105
S100A2 S100 calcium binding protein A2 -2.4493
MRPS16 mitochondrial ribosomal protein S16 -2.44865
SREBF1 sterol regulatory element binding transcription factor 1 -2.43445
RPL39L ribosomal protein L39-like -2.4294
BORA bora, aurora kinase A activator -2.41085
RNF43 ring finger protein 43 -2.4002
NCAPG2 non-SMC condensin II complex, subunit G2 -2.38705
MCM9 minichromosome maintenance complex component 9 -2.37045
PBK PDZ binding kinase -2.37
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -2.36395
YEATS4 YEATS domain containing 4 -2.3499
CDCA8 cell division cycle associated 8 -2.34335
RPA3 replication protein A3, 14kDa -2.3424
RMI1 RecQ mediated genome instability 1 -2.3399
PSRC1 proline/serine-rich coiled-coil 1 -2.339
PENK proenkephalin -2.3372
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.334
TECR trans-2,3-enoyl-CoA reductase -2.33385
EMC9 ER membrane protein complex subunit 9 -2.32885
DNM1 dynamin 1 -2.3284
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.3256
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.31275
CDT1 chromatin licensing and DNA replication factor 1 -2.30875
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.2847
MICALL2 MICAL-like 2 -2.2833
CDC20 cell division cycle 20 -2.26495
CDC25B cell division cycle 25B -2.25445
ADD3 adducin 3 (gamma) -2.25425
SPC25 SPC25, NDC80 kinetochore complex component -2.24495
RANGAP1 Ran GTPase activating protein 1 -2.24327
KIF2C kinesin family member 2C -2.24288
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.2328
KIF4A kinesin family member 4A -2.22245
GPSM2 G-protein signaling modulator 2 -2.22183
NPM3 nucleophosmin/nucleoplasmin 3 -2.2206
WASF1 WAS protein family, member 1 -2.20735
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.1864
TROAP trophinin associated protein -2.1826
CRTC3 CREB regulated transcription coactivator 3 -2.15865
PGM1 phosphoglucomutase 1 -2.1585
TACC3 transforming, acidic coiled-coil containing protein 3 -2.1582
NCAPD2 non-SMC condensin I complex, subunit D2 -2.15795
MBIP MAP3K12 binding inhibitory protein 1 -2.1524
FOXM1 forkhead box M1 -2.14945
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.14925
MCM5 minichromosome maintenance complex component 5 -2.14097
GMDS GDP-mannose 4,6-dehydratase -2.1381
CCL13 chemokine (C-C motif) ligand 13 -2.1235
CDKN3 cyclin-dependent kinase inhibitor 3 -2.1165
PHGDH phosphoglycerate dehydrogenase -2.11485
PCNA proliferating cell nuclear antigen -2.1048
PTTG1 pituitary tumor-transforming 1 -2.09765
PTBP1 polypyrimidine tract binding protein 1 -2.08651
UROS uroporphyrinogen III synthase -2.0823
KAT5 K(lysine) acetyltransferase 5 -2.07355
DCAF11 DDB1 and CUL4 associated factor 11 -2.07317
PPIE peptidylprolyl isomerase E (cyclophilin E) -2.07095
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.0634
ELP4 elongator acetyltransferase complex subunit 4 -2.0547
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.05153
NMU neuromedin U -2.05075
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.04715
R3HDM4 R3H domain containing 4 -2.04463
HAUS4 HAUS augmin-like complex, subunit 4 -2.04315
PIMREG PICALM interacting mitotic regulator -2.0419
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.0385
KIF14 kinesin family member 14 -2.03475
CBX3 chromobox homolog 3 -2.0289
CENPN centromere protein N -2.02472
TLCD3A TLC domain containing 3A -2.0238
XPO7 exportin 7 -2.01235
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.00745
TPX2 TPX2, microtubule-associated -2.0032