CRCGN017_MCF10A.WT.HP_24H:N14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenacetin 32.81 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

175 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:N14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 8.22285
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.53355
UGDH UDP-glucose 6-dehydrogenase 4.47765
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.3604
USP6NL USP6 N-terminal like 3.57655
KCTD5 potassium channel tetramerization domain containing 5 3.515
ADRB2 adrenoceptor beta 2, surface 3.35195
TIAM1 T-cell lymphoma invasion and metastasis 1 3.04857
GHR growth hormone receptor 2.966
RPL39L ribosomal protein L39-like 2.91085
E2F2 E2F transcription factor 2 2.7556
DENND2D DENN/MADD domain containing 2D 2.75525
MEOX1 mesenchyme homeobox 1 2.63025
TBPL1 TBP-like 1 2.55245
KDM3B lysine (K)-specific demethylase 3B 2.53555
RAB5B RAB5B, member RAS oncogene family 2.5193
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.4225
OBP2B odorant binding protein 2B 2.38125
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.37155
NELL1 NEL-like 1 (chicken) 2.363
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.3584
TMEM260 transmembrane protein 260 2.3484
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.31085
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.29205
MATN2 matrilin 2 2.28985
RPAP2 RNA polymerase II associated protein 2 2.28635
MYLIP myosin regulatory light chain interacting protein 2.26085
LYRM1 LYR motif containing 1 2.235
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.2343
SSBP2 single-stranded DNA binding protein 2 2.22385
RNF170 ring finger protein 170 2.19995
ZNF124 zinc finger protein 124 2.15645
MPC2 mitochondrial pyruvate carrier 2 2.12785
TNRC6B trinucleotide repeat containing 6B 2.10305
SUMO4 small ubiquitin-like modifier 4 2.09865
ZNF84 zinc finger protein 84 2.09115
CCNA1 cyclin A1 2.085
ODR4 odr-4 GPCR localization factor homolog 2.0805
REV1 REV1, polymerase (DNA directed) 2.06965
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.0487
SYCP2 synaptonemal complex protein 2 2.04853
TUSC3 tumor suppressor candidate 3 2.0404
ZNF587 zinc finger protein 587 2.0357
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2.023

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -7.17185
MT2A metallothionein 2A -5.65735
KRT14 keratin 14, type I -5.59995
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -5.11785
TUBA4A tubulin, alpha 4a -5.0
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -4.9726
AKT1 v-akt murine thymoma viral oncogene homolog 1 -4.91975
UFM1 ubiquitin-fold modifier 1 -4.4119
MSN moesin -4.3369
ETFB electron-transfer-flavoprotein, beta polypeptide -4.3333
TRAPPC3 trafficking protein particle complex 3 -4.1264
FPGS folylpolyglutamate synthase -4.1237
GFUS GDP-L-fucose synthase -3.96275
CTNND1 catenin (cadherin-associated protein), delta 1 -3.94975
NT5DC2 5'-nucleotidase domain containing 2 -3.94855
EXOSC4 exosome component 4 -3.94292
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -3.7602
SCRIB scribbled planar cell polarity protein -3.7265
PTDSS2 phosphatidylserine synthase 2 -3.68715
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -3.6728
PNKP polynucleotide kinase 3'-phosphatase -3.5673
COG4 component of oligomeric golgi complex 4 -3.5377
CNN2 calponin 2 -3.5273
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -3.43138
PLK1 polo-like kinase 1 -3.36185
DGAT1 diacylglycerol O-acyltransferase 1 -3.32375
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.32145
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -3.2991
ILK integrin-linked kinase -3.1881
CSK c-src tyrosine kinase -3.15505
CLTB clathrin, light chain B -3.1511
BOP1 block of proliferation 1 -3.10413
NUDC nudC nuclear distribution protein -3.0907
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -3.05543
RIC8A RIC8 guanine nucleotide exchange factor A -3.01665
AMDHD2 amidohydrolase domain containing 2 -2.93545
CLASRP CLK4-associating serine/arginine rich protein -2.93345
MT1X metallothionein 1X -2.93085
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.93045
TWF2 twinfilin actin binding protein 2 -2.91495
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.89325
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -2.88355
CD81 CD81 molecule -2.8591
AURKB aurora kinase B -2.7757
TRAP1 TNF receptor-associated protein 1 -2.72105
SORBS3 sorbin and SH3 domain containing 3 -2.71815
PFN1 profilin 1 -2.67065
CDC20 cell division cycle 20 -2.64535
MVP major vault protein -2.61355
GSDMD gasdermin D -2.5942
HSF1 heat shock transcription factor 1 -2.59107
MAP7D1 MAP7 domain containing 1 -2.58735
MTA1 metastasis associated 1 -2.5425
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.5413
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -2.5091
DDIT4 DNA-damage-inducible transcript 4 -2.49775
CHPF2 chondroitin polymerizing factor 2 -2.49673
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -2.4924
RAD51C RAD51 paralog C -2.4631
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.4521
TSSC4 tumor suppressing subtransferable candidate 4 -2.441
BSG basigin (Ok blood group) -2.4353
RNF126 ring finger protein 126 -2.4314
ZYX zyxin -2.42545
ANXA2 annexin A2 -2.41285
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -2.39755
TOLLIP toll interacting protein -2.39725
ENG endoglin -2.39625
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.387
HGH1 HGH1 homolog (S. cerevisiae) -2.38412
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.3741
MYDGF myeloid-derived growth factor -2.37098
ACTN1 actinin, alpha 1 -2.35371
RHOF ras homolog family member F (in filopodia) -2.34525
CCNP cyclin P -2.3438
MRPS2 mitochondrial ribosomal protein S2 -2.34135
ERCC2 excision repair cross-complementation group 2 -2.34085
PRPF19 pre-mRNA processing factor 19 -2.33435
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.30842
IFRD2 interferon-related developmental regulator 2 -2.3064
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.29695
HSPB1 heat shock 27kDa protein 1 -2.294
STX1A syntaxin 1A (brain) -2.29265
SBNO2 strawberry notch homolog 2 (Drosophila) -2.29035
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.2862
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.27145
TKT transketolase -2.2597
NAXD NAD(P)HX dehydratase -2.2573
PNPLA6 patatin-like phospholipase domain containing 6 -2.25725
RBM42 RNA binding motif protein 42 -2.2464
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.24193
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.2244
RPL8 ribosomal protein L8 -2.209
ACOD1 aconitate decarboxylase 1 -2.19645
WDR1 WD repeat domain 1 -2.17955
TNIP1 TNFAIP3 interacting protein 1 -2.1725
STK25 serine/threonine kinase 25 -2.1615
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.15885
PTBP1 polypyrimidine tract binding protein 1 -2.15848
PLEC plectin -2.15145
IER3 immediate early response 3 -2.14675
ZC3H3 zinc finger CCCH-type containing 3 -2.14625
LOC102724594 splicing factor U2AF 35 kDa subunit -2.1435
TFDP1 transcription factor Dp-1 -2.1213
CCDC68 coiled-coil domain containing 68 -2.1198
SLC35F6 solute carrier family 35, member F6 -2.11775
RUVBL1 RuvB-like AAA ATPase 1 -2.1159
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -2.1135
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.1108
PLSCR4 phospholipid scramblase 4 -2.10695
HRAS Harvey rat sarcoma viral oncogene homolog -2.10515
NPDC1 neural proliferation, differentiation and control, 1 -2.0971
LOC112694756 uncharaterized LOC112694756 -2.09562
CDT1 chromatin licensing and DNA replication factor 1 -2.0899
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -2.0854
PHC2 polyhomeotic homolog 2 (Drosophila) -2.08525
THOP1 thimet oligopeptidase 1 -2.08335
UNC13D unc-13 homolog D (C. elegans) -2.08265
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.07955
RANGAP1 Ran GTPase activating protein 1 -2.07472
MCOLN1 mucolipin 1 -2.06135
DAPK3 death-associated protein kinase 3 -2.06072
WRAP53 WD repeat containing, antisense to TP53 -2.05265
AGBL5 ATP/GTP binding protein-like 5 -2.04285
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -2.03455
FLNA filamin A, alpha -2.02865
FOSL1 FOS-like antigen 1 -2.02565
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -2.0204
MECR mitochondrial trans-2-enoyl-CoA reductase -2.01265
SSRP1 structure specific recognition protein 1 -2.0043
CLIP2 CAP-GLY domain containing linker protein 2 -2.00295