CRCGN017_MCF10A.WT.HP_24H:N24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indeno[1,2,3-cd]pyrene 11.31 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:N24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PROS1 protein S (alpha) 4.7516
LYN LYN proto-oncogene, Src family tyrosine kinase 4.38315
CNRIP1 cannabinoid receptor interacting protein 1 4.26865
HBB hemoglobin, beta 3.68422
HBA1 hemoglobin, alpha 1 3.56339
IGHMBP2 immunoglobulin mu binding protein 2 3.35743
ISOC1 isochorismatase domain containing 1 3.03615
WDR7 WD repeat domain 7 3.01285
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.0085
ACAA1 acetyl-CoA acyltransferase 1 2.9386
SLC35B1 solute carrier family 35, member B1 2.90545
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.89075
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.8093
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.7064
FGL1 fibrinogen-like 1 2.65555
TLR4 toll-like receptor 4 2.49775
LOC122526780 uncharacterized LOC122526780 2.4735
RHOBTB1 Rho-related BTB domain containing 1 2.45295
C5 complement component 5 2.37835
DENND2D DENN/MADD domain containing 2D 2.3128
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.2701
ELOVL2 ELOVL fatty acid elongase 2 2.2627
LGMN legumain 2.25425
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.19335
GZMK granzyme K (granzyme 3; tryptase II) 2.14585
NOSIP nitric oxide synthase interacting protein 2.1344
PLXDC1 plexin domain containing 1 2.12437
RAB27A RAB27A, member RAS oncogene family 2.1161
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 2.10555
OLFML2B olfactomedin-like 2B 2.08565
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.0689
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.06845
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.0312
BAZ2B bromodomain adjacent to zinc finger domain, 2B 2.0304
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.0275
H2AX H2A.X variant histone 2.00375

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -4.79025
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.1686
RBM34 RNA binding motif protein 34 -2.87707
THAP11 THAP domain containing 11 -2.7919
RGS2 regulator of G-protein signaling 2 -2.68445
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.62537
NUP88 nucleoporin 88kDa -2.59127
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.57445
CBR3 carbonyl reductase 3 -2.3272
MXI1 MAX interactor 1, dimerization protein -2.25875
SLAMF1 signaling lymphocytic activation molecule family member 1 -2.20025
PFN1 profilin 1 -2.1577
CNIH4 cornichon family AMPA receptor auxiliary protein 4 -2.14975
EFL1 elongation factor like GTPase 1 -2.14475
SGF29 SAGA complex associated factor 29 -2.12015
EXOSC4 exosome component 4 -2.11715
ANKFY1 ankyrin repeat and FYVE domain containing 1 -2.03695
MRPL37 mitochondrial ribosomal protein L37 -2.03505
GBP2 guanylate binding protein 2, interferon-inducible -2.02475
LAMA5 laminin, alpha 5 -2.00975