CRCGN017_MCF10A.WT.HP_24H:O02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

332 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:O02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 5.6704
MAMLD1 mastermind-like domain containing 1 5.12328
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.65893
WFS1 Wolfram syndrome 1 (wolframin) 4.52261
ITFG1 integrin alpha FG-GAP repeat containing 1 4.25128
COMP cartilage oligomeric matrix protein 4.09526
COL11A1 collagen, type XI, alpha 1 4.05509
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.95416
EMSY EMSY transcriptional repressor, BRCA2 interacting 3.8436
CBR4 carbonyl reductase 4 3.65556
ZNF45 zinc finger protein 45 3.50837
ABHD18 abhydrolase domain containing 18 3.43773
TASL TLR adaptor interacting with endolysosomal SLC15A4 3.40853
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 3.34629
DACT1 dishevelled-binding antagonist of beta-catenin 1 3.28496
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 3.15255
RSF1 remodeling and spacing factor 1 3.14847
TRDMT1 tRNA aspartic acid methyltransferase 1 3.14014
KATNBL1 katanin p80 subunit B-like 1 3.06444
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 3.02859
ZNF112 zinc finger protein 112 3.02054
ACAA1 acetyl-CoA acyltransferase 1 3.00881
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.98917
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 2.97608
NOD2 nucleotide-binding oligomerization domain containing 2 2.97424
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 2.91878
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.9082
ZNF180 zinc finger protein 180 2.8812
GPATCH8 G patch domain containing 8 2.85607
TRAPPC11 trafficking protein particle complex 11 2.85441
RASL11B RAS-like, family 11, member B 2.83038
ZNF518A zinc finger protein 518A 2.78214
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.77787
ZNF227 zinc finger protein 227 2.77269
ZNF696 zinc finger protein 696 2.76254
IGHMBP2 immunoglobulin mu binding protein 2 2.73225
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.72068
ZNF623 zinc finger protein 623 2.7031
CCDC69 coiled-coil domain containing 69 2.64333
MICB MHC class I polypeptide-related sequence B 2.64126
LY6H lymphocyte antigen 6 complex, locus H 2.62445
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 2.62079
CCNA1 cyclin A1 2.61592
ZNF34 zinc finger protein 34 2.59544
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.58664
RECK reversion-inducing-cysteine-rich protein with kazal motifs 2.56682
ZNF224 zinc finger protein 224 2.55643
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.54816
ZNF365 zinc finger protein 365 2.54221
ZNF322 zinc finger protein 322 2.54042
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 2.53881
CSAD cysteine sulfinic acid decarboxylase 2.53834
MPPED2 metallophosphoesterase domain containing 2 2.53514
DEPDC5 DEP domain containing 5 2.53146
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.5151
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.50405
DNA2 DNA replication helicase/nuclease 2 2.49567
IFT81 intraflagellar transport 81 2.49053
PLA2G15 phospholipase A2, group XV 2.48076
METTL2A methyltransferase like 2A 2.47932
GOLGA8N golgin A8 family, member N 2.4787
FMO3 flavin containing monooxygenase 3 2.47709
ZNF223 zinc finger protein 223 2.47518
KANSL1L KAT8 regulatory NSL complex subunit 1-like 2.46447
CAMK1D calcium/calmodulin-dependent protein kinase ID 2.44874
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.44396
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa 2.43978
STK38L serine/threonine kinase 38 like 2.43619
RECQL RecQ helicase-like 2.4358
FRMD4A FERM domain containing 4A 2.43505
RBM41 RNA binding motif protein 41 2.43064
EXO5 exonuclease 5 2.42181
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.42176
SAXO6 stabilizer of axonemal microtubules 6 2.42101
KLHL3 kelch-like family member 3 2.42019
ZFPM2 zinc finger protein, FOG family member 2 2.41389
NRBF2 nuclear receptor binding factor 2 2.37844
MAST3 microtubule associated serine/threonine kinase 3 2.37841
E2F1 E2F transcription factor 1 2.37749
DBF4B DBF4 zinc finger B 2.37725
CENPQ centromere protein Q 2.37628
GPR65 G protein-coupled receptor 65 2.37078
ZSCAN26 zinc finger and SCAN domain containing 26 2.36365
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 2.35624
ALPK1 alpha-kinase 1 2.35367
UVRAG UV radiation resistance associated 2.34913
WNT2 wingless-type MMTV integration site family member 2 2.34612
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.33891
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.33812
FXYD7 FXYD domain containing ion transport regulator 7 2.33683
GCA grancalcin, EF-hand calcium binding protein 2.33537
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.33401
ZNF135 zinc finger protein 135 2.3272
CEP135 centrosomal protein 135kDa 2.3204
BBS7 Bardet-Biedl syndrome 7 2.30887
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.30853
DSCC1 DNA replication and sister chromatid cohesion 1 2.30851
PCDHGA5 protocadherin gamma subfamily A, 5 2.30403
ADGRB2 adhesion G protein-coupled receptor B2 2.30161
NME5 NME/NM23 family member 5 2.29839
DZANK1 double zinc ribbon and ankyrin repeat domains 1 2.29117
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.28874
KLHL2 kelch-like family member 2 2.28834
ABI3BP ABI family, member 3 (NESH) binding protein 2.28692
HLF hepatic leukemia factor 2.28534
ZNF184 zinc finger protein 184 2.28408
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.28164
RIT2 Ras-like without CAAX 2 2.28131
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.27829
MARK3 MAP/microtubule affinity-regulating kinase 3 2.27546
JRKL JRK-like 2.27404
FBXL2 F-box and leucine-rich repeat protein 2 2.2658
TRAPPC13 trafficking protein particle complex 13 2.26409
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.26283
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) 2.2603
RNF38 ring finger protein 38 2.25773
ZNF280D zinc finger protein 280D 2.25625
OLIG2 oligodendrocyte lineage transcription factor 2 2.25452
CFAP20 cilia and flagella associated protein 20 2.24715
GLRB glycine receptor, beta 2.24563
TMEM35A transmembrane protein 35A 2.24545
TM6SF1 transmembrane 6 superfamily member 1 2.24491
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.24224
GFRA3 GDNF family receptor alpha 3 2.23618
CPEB3 cytoplasmic polyadenylation element binding protein 3 2.23263
LEMD3 LEM domain containing 3 2.22925
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.22048
THAP12 THAP domain containing 12 2.2197
CUL3 cullin 3 2.2172
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.20847
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.20664
TTC33 tetratricopeptide repeat domain 33 2.20155
GPM6B glycoprotein M6B 2.20137
TRAPPC6A trafficking protein particle complex 6A 2.1987
ZMYM1 zinc finger, MYM-type 1 2.19389
CRYM crystallin, mu 2.1936
SCRN3 secernin 3 2.1936
EGFL6 EGF-like-domain, multiple 6 2.18746
NTF3 neurotrophin 3 2.18491
ISOC1 isochorismatase domain containing 1 2.18202
ZBTB3 zinc finger and BTB domain containing 3 2.17356
ECEL1 endothelin converting enzyme-like 1 2.17239
ZNF551 zinc finger protein 551 2.17143
ACADL acyl-CoA dehydrogenase, long chain 2.16948
MAPK10 mitogen-activated protein kinase 10 2.16701
BET1 Bet1 golgi vesicular membrane trafficking protein 2.16346
ZNF232 zinc finger protein 232 2.16211
ZNF362 zinc finger protein 362 2.15878
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.15842
ZNF257 zinc finger protein 257 2.15629
KDM8 lysine (K)-specific demethylase 8 2.15479
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2.1545
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.15132
POLK polymerase (DNA directed) kappa 2.14468
ZNF350 zinc finger protein 350 2.14371
ATRNL1 attractin-like 1 2.14322
ZW10 zw10 kinetochore protein 2.14246
CEP41 centrosomal protein 41kDa 2.13772
CSPP1 centrosome and spindle pole associated protein 1 2.13563
ADPGK ADP-dependent glucokinase 2.1356
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2.13536
SULT4A1 sulfotransferase family 4A, member 1 2.13317
GHR growth hormone receptor 2.13258
MBTD1 mbt domain containing 1 2.13191
CD180 CD180 molecule 2.13087
RBBP5 retinoblastoma binding protein 5 2.13021
ZNF667 zinc finger protein 667 2.13013
CCN5 cellular communication network factor 5 2.12783
FGD2 FYVE, RhoGEF and PH domain containing 2 2.12713
CPNE6 copine VI (neuronal) 2.12583
AAMDC adipogenesis associated, Mth938 domain containing 2.12508
OPCML opioid binding protein/cell adhesion molecule-like 2.12434
CXCR4 chemokine (C-X-C motif) receptor 4 2.12341
FMR1 fragile X mental retardation 1 2.12246
FAM131B family with sequence similarity 131, member B 2.12193
VTCN1 V-set domain containing T cell activation inhibitor 1 2.12079
RHEB Ras homolog enriched in brain 2.11938
NGRN neugrin, neurite outgrowth associated 2.11735
PCDHGA8 protocadherin gamma subfamily A, 8 2.11435
EHD4 EH-domain containing 4 2.11403
SMIM41 small integral membrane protein 41 2.10952
IL12RB2 interleukin 12 receptor, beta 2 2.10722
TLR1 toll-like receptor 1 2.1055
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 2.09985
DOC2A double C2-like domains, alpha 2.0896
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.08928
KRIT1 KRIT1, ankyrin repeat containing 2.08828
PLPBP pyridoxal phosphate binding protein 2.08801
DOCK3 dedicator of cytokinesis 3 2.0878
ATF7IP2 activating transcription factor 7 interacting protein 2 2.08451
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.08373
ASTN1 astrotactin 1 2.08125
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 2.07957
S1PR2 sphingosine-1-phosphate receptor 2 2.07589
PCNP PEST proteolytic signal containing nuclear protein 2.07448
ZNF107 zinc finger protein 107 2.07378
RAG2 recombination activating gene 2 2.07042
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.06908
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.06819
FAM149A family with sequence similarity 149, member A 2.06805
STAU2 staufen double-stranded RNA binding protein 2 2.05766
PBX3 pre-B-cell leukemia homeobox 3 2.05467
NKIRAS2 NFKB inhibitor interacting Ras-like 2 2.05375
BMP4 bone morphogenetic protein 4 2.05038
ZNF75D zinc finger protein 75D 2.05031
FOXL2 forkhead box L2 2.04933
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.04642
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.04508
TCEAL1 transcription elongation factor A (SII)-like 1 2.04403
AASS aminoadipate-semialdehyde synthase 2.04375
CA10 carbonic anhydrase X 2.04367
RPGRIP1L RPGRIP1-like 2.04352
PSME3IP1 proteasome activator subunit 3 interacting protein 1 2.03943
GOLGA6L9 golgin A6 family-like 9 2.03678
NME6 NME/NM23 nucleoside diphosphate kinase 6 2.0364
ZNF813 zinc finger protein 813 2.03377
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 2.03331
CDADC1 cytidine and dCMP deaminase domain containing 1 2.0321
HBB hemoglobin, beta 2.03086
PLGLB2 plasminogen-like B2 2.03086
AGK acylglycerol kinase 2.02985
RPA4 replication protein A4, 30kDa 2.02947
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.0263
ANKRD37 ankyrin repeat domain 37 2.02622
SFTPD surfactant protein D 2.02536
OVGP1 oviductal glycoprotein 1, 120kDa 2.02411
SPATA7 spermatogenesis associated 7 2.02137
PTGDR prostaglandin D2 receptor (DP) 2.02118
CCNH cyclin H 2.02049
DCHS2 dachsous cadherin-related 2 2.01866
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.01823
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 2.018
ACSM3 acyl-CoA synthetase medium-chain family member 3 2.01565
GDAP2 ganglioside induced differentiation associated protein 2 2.00964
RYR2 ryanodine receptor 2 (cardiac) 2.00962
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.00848
TMPRSS3 transmembrane protease, serine 3 2.00706
ZNF606 zinc finger protein 606 2.00407
ALMS1 Alstrom syndrome protein 1 2.00363
FPGT fucose-1-phosphate guanylyltransferase 2.00331
ZNF701 zinc finger protein 701 2.00267
C5 complement component 5 2.00248

decreased expression

Symbol Name Standardized Value
BAG3 BCL2-associated athanogene 3 -5.59671
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.9402
CCNB2 cyclin B2 -4.67507
CCNB1 cyclin B1 -4.62918
TSPAN4 tetraspanin 4 -4.62035
CCDC86 coiled-coil domain containing 86 -4.56699
HSPD1 heat shock 60kDa protein 1 (chaperonin) -4.33657
LAP3 leucine aminopeptidase 3 -4.07665
AKT1 v-akt murine thymoma viral oncogene homolog 1 -4.02901
GDF15 growth differentiation factor 15 -3.98763
ETFB electron-transfer-flavoprotein, beta polypeptide -3.91949
TM9SF3 transmembrane 9 superfamily member 3 -3.8669
SNX7 sorting nexin 7 -3.60063
STXBP2 syntaxin binding protein 2 -3.3856
CARMIL1 capping protein regulator and myosin 1 linker 1 -3.36538
MT2A metallothionein 2A -3.15696
PFN1 profilin 1 -3.07989
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.97288
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.95087
CDC20 cell division cycle 20 -2.70462
C1QA complement component 1, q subcomponent, A chain -2.68271
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.67996
CREG1 cellular repressor of E1A-stimulated genes 1 -2.63222
LOC112694756 uncharaterized LOC112694756 -2.63127
ANO10 anoctamin 10 -2.62957
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.60187
PRB4 proline-rich protein BstNI subfamily 4 -2.59738
WASF3 WAS protein family, member 3 -2.59618
TBC1D16 TBC1 domain family, member 16 -2.55335
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.53325
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.50563
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -2.50419
DCBLD2 discoidin, CUB and LCCL domain containing 2 -2.4768
FPGS folylpolyglutamate synthase -2.47612
C1QB complement component 1, q subcomponent, B chain -2.46483
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.44707
TMED3 transmembrane emp24 protein transport domain containing 3 -2.43779
SCAMP2 secretory carrier membrane protein 2 -2.41109
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.38883
TPM4 tropomyosin 4 -2.37171
TWF2 twinfilin actin binding protein 2 -2.37012
ATOX1 antioxidant 1 copper chaperone -2.34589
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.33002
FOSL1 FOS-like antigen 1 -2.29981
CGREF1 cell growth regulator with EF-hand domain 1 -2.28399
CGGBP1 CGG triplet repeat binding protein 1 -2.26654
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.24985
ANGPTL4 angiopoietin-like 4 -2.24347
PRB3 proline-rich protein BstNI subfamily 3 -2.24156
SLC67A1 solute carrier family 67 member 1 -2.23437
SCARB1 scavenger receptor class B, member 1 -2.22986
MUC7 mucin 7, secreted -2.22566
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 -2.22036
VAMP5 vesicle-associated membrane protein 5 -2.21708
TPX2 TPX2, microtubule-associated -2.19477
NECTIN4 nectin cell adhesion molecule 4 -2.19456
FOXD1 forkhead box D1 -2.18386
GID4 GID complex subunit 4 -2.16018
CDKN3 cyclin-dependent kinase inhibitor 3 -2.15381
MRPS16 mitochondrial ribosomal protein S16 -2.14406
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.13432
LOX lysyl oxidase -2.1343
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.12582
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.12537
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.12251
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.12138
AIM2 absent in melanoma 2 -2.11954
CARM1 coactivator-associated arginine methyltransferase 1 -2.11645
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.099
AMDHD2 amidohydrolase domain containing 2 -2.09642
ZNF706 zinc finger protein 706 -2.0879
RLIM ring finger protein, LIM domain interacting -2.0868
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.07877
SPAG7 sperm associated antigen 7 -2.07555
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.07411
TMEM214 transmembrane protein 214 -2.07264
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.06573
TLE3 transducin-like enhancer of split 3 -2.05886
TACC3 transforming, acidic coiled-coil containing protein 3 -2.05165
PRH1 proline-rich protein HaeIII subfamily 1 -2.05099
MALT1 MALT1 paracaspase -2.05099
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) -2.04583
VTA1 vesicle (multivesicular body) trafficking 1 -2.03685
GPX3 glutathione peroxidase 3 -2.02787
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.02379
NRN1 neuritin 1 -2.01916
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.01562
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -2.01292
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.00648
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.00087