CRCGN017_MCF10A.WT.HP_24H:O03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

130 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:O03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.09905
BMP4 bone morphogenetic protein 4 4.96194
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.28045
SNAP25 synaptosomal-associated protein, 25kDa 3.51474
COMP cartilage oligomeric matrix protein 3.24537
TLR4 toll-like receptor 4 3.11143
MAMLD1 mastermind-like domain containing 1 3.05612
GADD45A growth arrest and DNA-damage-inducible, alpha 3.01907
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.85448
CCL2 chemokine (C-C motif) ligand 2 2.81442
CGRRF1 cell growth regulator with ring finger domain 1 2.64976
TRAK2 trafficking protein, kinesin binding 2 2.62992
DENND2D DENN/MADD domain containing 2D 2.59818
METTL4 methyltransferase like 4 2.55748
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.54213
HLA-DRA major histocompatibility complex, class II, DR alpha 2.5034
SMN2 survival of motor neuron 2, centromeric 2.40973
AP1AR adaptor-related protein complex 1 associated regulatory protein 2.40467
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.3696
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.28241
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.25975
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.25492
ZNF8 zinc finger protein 8 2.24835
HAUS3 HAUS augmin-like complex, subunit 3 2.2425
NSG2 neuronal vesicle trafficking associated 2 2.22758
KRABD4 KRAB domain containing 4 2.22508
SYT1 synaptotagmin I 2.22192
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.18804
STXBP3 syntaxin binding protein 3 2.18681
RGS4 regulator of G-protein signaling 4 2.17991
SNX11 sorting nexin 11 2.14429
CARTPT CART prepropeptide 2.14237
WDR47 WD repeat domain 47 2.13981
GSTCD glutathione S-transferase, C-terminal domain containing 2.13513
EGR4 early growth response 4 2.12641
GPR21 G protein-coupled receptor 21 2.11262
GPR65 G protein-coupled receptor 65 2.08321
ITGA8 integrin, alpha 8 2.08076
MRPS10 mitochondrial ribosomal protein S10 2.07451
ELOVL6 ELOVL fatty acid elongase 6 2.07354
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.06686
AIRIM AFG2 interacting ribosome maturation factor 2.05274
STARD8 StAR-related lipid transfer (START) domain containing 8 2.04123
CCND1 cyclin D1 2.03064
ANAPC10 anaphase promoting complex subunit 10 2.0199
INTS7 integrator complex subunit 7 2.01875
FPGT fucose-1-phosphate guanylyltransferase 2.01502
CYCS cytochrome c, somatic 2.01179
TCEAL1 transcription elongation factor A (SII)-like 1 2.00936

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -4.93419
HMG20B high mobility group 20B -4.06746
AKT1 v-akt murine thymoma viral oncogene homolog 1 -3.87746
TKT transketolase -3.78507
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -3.75801
CHIC2 cysteine-rich hydrophobic domain 2 -3.67027
MVP major vault protein -3.5814
ETFB electron-transfer-flavoprotein, beta polypeptide -3.54839
PLK1 polo-like kinase 1 -3.54599
COG4 component of oligomeric golgi complex 4 -3.43652
MSN moesin -3.19935
DSG2 desmoglein 2 -3.16427
GFUS GDP-L-fucose synthase -3.11094
CLTB clathrin, light chain B -2.88898
DYNLT3 dynein, light chain, Tctex-type 3 -2.8257
CD81 CD81 molecule -2.79538
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.78178
KIF2C kinesin family member 2C -2.75511
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.73737
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.67681
BASP1 brain abundant, membrane attached signal protein 1 -2.6629
PTOV1 prostate tumor overexpressed 1 -2.61919
CSK c-src tyrosine kinase -2.57472
NT5DC2 5'-nucleotidase domain containing 2 -2.57235
VAT1 vesicle amine transport 1 -2.5579
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.54783
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.54206
PNPLA6 patatin-like phospholipase domain containing 6 -2.54083
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.52648
FPGS folylpolyglutamate synthase -2.51977
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.49214
MTA1 metastasis associated 1 -2.48416
TBC1D10B TBC1 domain family, member 10B -2.46834
EXOSC4 exosome component 4 -2.45153
CDC20 cell division cycle 20 -2.43994
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -2.41341
ATP13A1 ATPase type 13A1 -2.40445
XPO7 exportin 7 -2.40033
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -2.39128
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.37115
MZT2B mitotic spindle organizing protein 2B -2.35632
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.35542
TMEM214 transmembrane protein 214 -2.34974
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.34682
HSPB1 heat shock 27kDa protein 1 -2.34461
GIPC1 GIPC PDZ domain containing family, member 1 -2.3152
LOC112694756 uncharaterized LOC112694756 -2.31385
PRKCD protein kinase C, delta -2.29966
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.29194
CDK6 cyclin-dependent kinase 6 -2.28972
RBM42 RNA binding motif protein 42 -2.28647
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.28294
SORBS3 sorbin and SH3 domain containing 3 -2.2774
ATP5F1D ATP synthase F1 subunit delta -2.27438
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.26464
TRIP10 thyroid hormone receptor interactor 10 -2.23976
CDC25B cell division cycle 25B -2.22369
CARM1 coactivator-associated arginine methyltransferase 1 -2.21475
DNM2 dynamin 2 -2.21099
SSH3 slingshot protein phosphatase 3 -2.20263
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -2.20179
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.18992
AATF apoptosis antagonizing transcription factor -2.16106
PFN1 profilin 1 -2.1592
ZDHHC24 zinc finger, DHHC-type containing 24 -2.15702
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -2.15055
BRMS1L breast cancer metastasis-suppressor 1-like -2.14227
TP53 tumor protein p53 -2.13538
SPAG7 sperm associated antigen 7 -2.11283
PES1 pescadillo ribosomal biogenesis factor 1 -2.10555
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 -2.07103
BCR breakpoint cluster region -2.0592
UPK1B uroplakin 1B -2.05624
ILK integrin-linked kinase -2.05242
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.04993
PNKP polynucleotide kinase 3'-phosphatase -2.04624
DDIT4 DNA-damage-inducible transcript 4 -2.04076
DEF6 differentially expressed in FDCP 6 homolog (mouse) -2.0322
FAM50A family with sequence similarity 50, member A -2.00772
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.00713
SCAP SREBF chaperone -2.00077