CRCGN017_MCF10A.WT.HP_24H:O05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:O05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 7.11731
CXCR4 chemokine (C-X-C motif) receptor 4 4.81593
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.7304
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.33537
IGFBP3 insulin-like growth factor binding protein 3 4.25481
WDR7 WD repeat domain 7 3.81859
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 3.68617
GPER1 G protein-coupled estrogen receptor 1 3.22743
CCP110 centriolar coiled coil protein 110kDa 3.11182
SOX2 SRY (sex determining region Y)-box 2 3.05475
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.01288
COMP cartilage oligomeric matrix protein 3.01093
MAMLD1 mastermind-like domain containing 1 2.79031
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.62743
BAMBI BMP and activin membrane-bound inhibitor 2.58111
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.49684
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.47465
EGF epidermal growth factor 2.46957
CSRNP3 cysteine-serine-rich nuclear protein 3 2.46756
KIAA0319 KIAA0319 2.44413
CUZD1 CUB and zona pellucida-like domains 1 2.43481
SPIN2B spindlin family, member 2B 2.42132
AADAC arylacetamide deacetylase 2.36251
CFAP69 cilia and flagella associated protein 69 2.33269
LECT2 leukocyte cell-derived chemotaxin 2 2.30292
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 2.30267
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.27663
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.26925
ADGRL4 adhesion G protein-coupled receptor L4 2.23486
ZW10 zw10 kinetochore protein 2.19593
NUAK1 NUAK family, SNF1-like kinase, 1 2.19236
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.17923
LY6H lymphocyte antigen 6 complex, locus H 2.1731
EMCN endomucin 2.16001
MYF5 myogenic factor 5 2.15551
TLR4 toll-like receptor 4 2.15231
LDOC1 leucine zipper, down-regulated in cancer 1 2.14255
BAAT bile acid CoA:amino acid N-acyltransferase 2.138
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 2.12182
VEGFD vascular endothelial growth factor D 2.11458
PARM1 prostate androgen-regulated mucin-like protein 1 2.08388
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.07905
ZNF8 zinc finger protein 8 2.07361
ANGPTL3 angiopoietin-like 3 2.07254
KCNIP2 Kv channel interacting protein 2 2.07098
THAP10 THAP domain containing 10 2.06338
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.06334
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.05985
SLC17A2 solute carrier family 17, member 2 2.04703
SPX spexin hormone 2.0451
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.03679
DGKB diacylglycerol kinase, beta 90kDa 2.03375
F13B coagulation factor XIII, B polypeptide 2.03221
SEC14L5 SEC14-like 5 (S. cerevisiae) 2.02789
REG3A regenerating islet-derived 3 alpha 2.02768
OR3A3 olfactory receptor, family 3, subfamily A, member 3 2.02756
AKR1C4 aldo-keto reductase family 1, member C4 2.01953
RLN2 relaxin 2 2.01676
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.01045
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 2.00073

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -4.24188
KRT14 keratin 14, type I -4.23891
PRPF4 pre-mRNA processing factor 4 -3.6291
COG2 component of oligomeric golgi complex 2 -3.43689
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.41839
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.30335
UFM1 ubiquitin-fold modifier 1 -3.17471
HSPA1A heat shock 70kDa protein 1A -3.10836
SCYL3 SCY1-like 3 (S. cerevisiae) -3.08296
AKT1 v-akt murine thymoma viral oncogene homolog 1 -2.98789
TES testin LIM domain protein -2.91661
PLK1 polo-like kinase 1 -2.74211
MSMO1 methylsterol monooxygenase 1 -2.67991
CYCS cytochrome c, somatic -2.67823
TUBA4A tubulin, alpha 4a -2.6338
VDAC1 voltage-dependent anion channel 1 -2.62925
GNPAT glyceronephosphate O-acyltransferase -2.60374
VAT1 vesicle amine transport 1 -2.52129
GMPPA GDP-mannose pyrophosphorylase A -2.48827
PIAS3 protein inhibitor of activated STAT, 3 -2.48407
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.48299
ANO10 anoctamin 10 -2.46089
MAPK13 mitogen-activated protein kinase 13 -2.45957
LRP10 low density lipoprotein receptor-related protein 10 -2.44002
TLCD3A TLC domain containing 3A -2.39508
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.34988
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.29253
SPAG7 sperm associated antigen 7 -2.29174
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.26595
MVP major vault protein -2.25325
STXBP1 syntaxin binding protein 1 -2.22324
INPPL1 inositol polyphosphate phosphatase-like 1 -2.20173
GFUS GDP-L-fucose synthase -2.19241
TNIP1 TNFAIP3 interacting protein 1 -2.16085
ETFB electron-transfer-flavoprotein, beta polypeptide -2.13182
KIF2C kinesin family member 2C -2.13035
ARF1 ADP-ribosylation factor 1 -2.11833
TRAPPC3 trafficking protein particle complex 3 -2.11653
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.09422
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.07257
STXBP2 syntaxin binding protein 2 -2.06211
ABITRAM actin binding transcription modulator -2.04704
HSPB1 heat shock 27kDa protein 1 -2.00405