CRCGN017_MCF10A.WT.HP_24H:O16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dichlorvos 101.38 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

292 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:O16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 5.7336
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.34905
TP53BP2 tumor protein p53 binding protein 2 5.11585
WIF1 WNT inhibitory factor 1 5.06525
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.3067
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 3.96475
LOXL1 lysyl oxidase-like 1 3.57135
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.46925
CNRIP1 cannabinoid receptor interacting protein 1 3.4424
COMP cartilage oligomeric matrix protein 3.24765
HAT1 histone acetyltransferase 1 3.06795
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.0578
FGF1 fibroblast growth factor 1 (acidic) 3.02047
ACAA1 acetyl-CoA acyltransferase 1 2.93432
ZNF350 zinc finger protein 350 2.9153
WDR7 WD repeat domain 7 2.89395
COL11A1 collagen, type XI, alpha 1 2.8821
RAB31 RAB31, member RAS oncogene family 2.86127
NME5 NME/NM23 family member 5 2.8283
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 2.80258
ATMIN ATM interactor 2.7931
ZNF197 zinc finger protein 197 2.7438
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 2.73305
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.7283
ZNF813 zinc finger protein 813 2.71535
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.66515
TMEM100 transmembrane protein 100 2.65485
PDE1A phosphodiesterase 1A, calmodulin-dependent 2.6279
TXNDC9 thioredoxin domain containing 9 2.618
PEX11A peroxisomal biogenesis factor 11 alpha 2.61647
CROT carnitine O-octanoyltransferase 2.6013
B3GAT1 beta-1,3-glucuronyltransferase 1 2.5946
FXYD7 FXYD domain containing ion transport regulator 7 2.5916
ITGAV integrin, alpha V 2.52255
AGR2 anterior gradient 2 2.4757
GOLGA8F golgin A8 family, member F 2.45395
TBC1D12 TBC1 domain family, member 12 2.44655
CEP15 centrosomal protein 15 2.44005
ZNF267 zinc finger protein 267 2.4304
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.4225
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) 2.42165
MXRA7 matrix-remodelling associated 7 2.41335
MAPK10 mitogen-activated protein kinase 10 2.40805
CCP110 centriolar coiled coil protein 110kDa 2.3997
FAM13B family with sequence similarity 13, member B 2.3979
ISOC1 isochorismatase domain containing 1 2.3907
MCTP2 multiple C2 domains, transmembrane 2 2.37975
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.3768
STXBP3 syntaxin binding protein 3 2.3579
GPC5 glypican 5 2.33585
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 2.31233
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.3041
GPR183 G protein-coupled receptor 183 2.29525
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.2909
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.29007
NUP42 nucleoporin 42 2.28615
MCM9 minichromosome maintenance complex component 9 2.28025
MICALL1 MICAL-like 1 2.27242
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.27075
CHMP5 charged multivesicular body protein 5 2.26818
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.26732
MCMBP minichromosome maintenance complex binding protein 2.2664
ZNF22 zinc finger protein 22 2.25972
ZNF562 zinc finger protein 562 2.2469
NAP1L3 nucleosome assembly protein 1-like 3 2.2442
HPCA hippocalcin 2.2353
RYR3 ryanodine receptor 3 2.22905
COPS4 COP9 signalosome subunit 4 2.22025
ELMO2 engulfment and cell motility 2 2.21455
ART3 ADP-ribosyltransferase 3 2.2109
ZNF415 zinc finger protein 415 2.20755
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.2029
GRM3 glutamate receptor, metabotropic 3 2.20275
PTPRD protein tyrosine phosphatase, receptor type, D 2.2022
ANKMY2 ankyrin repeat and MYND domain containing 2 2.1973
GHR growth hormone receptor 2.1929
SGMS1 sphingomyelin synthase 1 2.1901
SDC2 syndecan 2 2.18777
FUBP3 far upstream element (FUSE) binding protein 3 2.1858
RWDD3 RWD domain containing 3 2.18485
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.18315
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.18315
TBPL1 TBP-like 1 2.17785
THAP10 THAP domain containing 10 2.1769
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.17115
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2.17107
AK5 adenylate kinase 5 2.1696
ZNF571 zinc finger protein 571 2.1622
KANSL1 KAT8 regulatory NSL complex subunit 1 2.15645
CD302 CD302 molecule 2.1563
LGI1 leucine-rich, glioma inactivated 1 2.1521
DCP2 decapping mRNA 2 2.1483
SYN2 synapsin II 2.12805
TMEM165 transmembrane protein 165 2.1265
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.11776
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.11
MYT1L myelin transcription factor 1-like 2.10978
RGS7 regulator of G-protein signaling 7 2.10105
SCHIP1 schwannomin interacting protein 1 2.08975
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.0837
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.08062
ZIC4 Zic family member 4 2.08055
PLAAT4 phospholipase A and acyltransferase 4 2.07775
CD160 CD160 molecule 2.07265
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.07118
MOG myelin oligodendrocyte glycoprotein 2.06997
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.06698
ELF2 E74-like factor 2 (ets domain transcription factor) 2.06565
MFF mitochondrial fission factor 2.06395
PCP4 Purkinje cell protein 4 2.0605
APLNR apelin receptor 2.059
MMP2 matrix metallopeptidase 2 2.05745
SNAP91 synaptosomal-associated protein, 91kDa 2.0539
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2.0513
CISD1 CDGSH iron sulfur domain 1 2.04595
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.0427
ESRRG estrogen-related receptor gamma 2.04222
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.03955
NBEA neurobeachin 2.03945
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2.0393
RAP2A RAP2A, member of RAS oncogene family 2.03895
NRGN neurogranin (protein kinase C substrate, RC3) 2.03835
ENC1 ectodermal-neural cortex 1 (with BTB domain) 2.0357
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.03545
BEX4 brain expressed, X-linked 4 2.03215
MAGEH1 melanoma antigen family H1 2.02955
MTMR6 myotubularin related protein 6 2.02865
YPEL1 yippee-like 1 (Drosophila) 2.02855
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 2.02725
TTC28 tetratricopeptide repeat domain 28 2.01875
KLHL2 kelch-like family member 2 2.0168
ZNF222 zinc finger protein 222 2.01405
SYN1 synapsin I 2.00995
ZEB2 zinc finger E-box binding homeobox 2 2.0083
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.0059
GAR1 GAR1 ribonucleoprotein 2.0031

decreased expression

Symbol Name Standardized Value
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -5.07745
KRT14 keratin 14, type I -5.0
TUBA4A tubulin, alpha 4a -5.0
FASTKD5 FAST kinase domains 5 -4.9077
OXA1L oxidase (cytochrome c) assembly 1-like -4.86325
TKT transketolase -4.8091
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -4.75075
AKT1 v-akt murine thymoma viral oncogene homolog 1 -4.7364
GFUS GDP-L-fucose synthase -4.5978
C2CD5 C2 calcium-dependent domain containing 5 -4.4951
ETFB electron-transfer-flavoprotein, beta polypeptide -4.4928
KIF14 kinesin family member 14 -4.4638
MT2A metallothionein 2A -4.45785
MSN moesin -4.41565
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -4.24725
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.93543
DDIT4 DNA-damage-inducible transcript 4 -3.86185
FPGS folylpolyglutamate synthase -3.81905
CARMIL1 capping protein regulator and myosin 1 linker 1 -3.6902
PFN1 profilin 1 -3.67125
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.53475
MVP major vault protein -3.4526
PHKA1 phosphorylase kinase, alpha 1 (muscle) -3.3939
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.33245
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -3.3011
COPS7A COP9 signalosome subunit 7A -3.28005
KIF2C kinesin family member 2C -3.27137
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -3.2136
LOC112694756 uncharaterized LOC112694756 -3.13225
TWF2 twinfilin actin binding protein 2 -3.1277
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.12375
PLK1 polo-like kinase 1 -3.12065
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -3.02035
SPAG7 sperm associated antigen 7 -2.9884
EVL Enah/Vasp-like -2.9365
MRPS2 mitochondrial ribosomal protein S2 -2.8634
HSPB1 heat shock 27kDa protein 1 -2.86325
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.8443
MT1X metallothionein 1X -2.84292
NPDC1 neural proliferation, differentiation and control, 1 -2.79205
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.76835
NT5DC2 5'-nucleotidase domain containing 2 -2.72285
ACTN4 actinin, alpha 4 -2.713
COG4 component of oligomeric golgi complex 4 -2.7103
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.69255
HGS hepatocyte growth factor-regulated tyrosine kinase substrate -2.6684
ADGRE5 adhesion G protein-coupled receptor E5 -2.66665
AXIN1 axin 1 -2.6512
CDC20 cell division cycle 20 -2.64535
PRRC2A proline-rich coiled-coil 2A -2.6379
MCOLN1 mucolipin 1 -2.6311
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.6088
UBA1 ubiquitin-like modifier activating enzyme 1 -2.59735
ITGA6 integrin, alpha 6 -2.5957
UCKL1 uridine-cytidine kinase 1-like 1 -2.59515
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.5804
BAG6 BCL2-associated athanogene 6 -2.5631
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.5583
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.55035
MRPS16 mitochondrial ribosomal protein S16 -2.53965
RBM10 RNA binding motif protein 10 -2.53537
NAP1L4 nucleosome assembly protein 1-like 4 -2.5136
WDR6 WD repeat domain 6 -2.4952
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -2.49458
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.46937
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.4681
H1-10 H1.10 linker histone -2.4674
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -2.4674
ECH1 enoyl CoA hydratase 1, peroxisomal -2.46515
RPL8 ribosomal protein L8 -2.4611
SORBS3 sorbin and SH3 domain containing 3 -2.44493
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -2.44457
MRPL12 mitochondrial ribosomal protein L12 -2.4149
CAPRIN1 cell cycle associated protein 1 -2.40452
VAT1 vesicle amine transport 1 -2.37375
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -2.3701
CLTB clathrin, light chain B -2.34398
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.3236
TRAP1 TNF receptor-associated protein 1 -2.30515
IFRD2 interferon-related developmental regulator 2 -2.3027
BCKDK branched chain ketoacid dehydrogenase kinase -2.29135
LSR lipolysis stimulated lipoprotein receptor -2.29075
RBM42 RNA binding motif protein 42 -2.2883
ATP5F1D ATP synthase F1 subunit delta -2.28562
RHOT2 ras homolog family member T2 -2.28365
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.27198
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -2.26745
NISCH nischarin -2.26235
TUFM Tu translation elongation factor, mitochondrial -2.2618
HRAS Harvey rat sarcoma viral oncogene homolog -2.25695
STAP2 signal transducing adaptor family member 2 -2.25635
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.2544
AMDHD2 amidohydrolase domain containing 2 -2.2538
MCF2L MCF.2 cell line derived transforming sequence-like -2.23677
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.22865
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -2.2055
HMG20B high mobility group 20B -2.19935
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.1871
VARS1 valyl-tRNA synthetase 1 -2.17925
CBR1 carbonyl reductase 1 -2.1773
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.17395
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.1623
ANKFY1 ankyrin repeat and FYVE domain containing 1 -2.1603
DDRGK1 DDRGK domain containing 1 -2.15835
CTDNEP1 CTD nuclear envelope phosphatase 1 -2.1576
WASHC4 WASH complex subunit 4 -2.15558
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.1485
CD81 CD81 molecule -2.14755
INF2 inverted formin, FH2 and WH2 domain containing -2.1443
CDK9 cyclin-dependent kinase 9 -2.1435
CHMP1A charged multivesicular body protein 1A -2.14275
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -2.14105
FAM3A family with sequence similarity 3, member A -2.13107
EIF4H eukaryotic translation initiation factor 4H -2.1278
RPL36 ribosomal protein L36 -2.1227
ACY1 aminoacylase 1 -2.1194
CABIN1 calcineurin binding protein 1 -2.11815
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.11605
TEX264 testis expressed 264 -2.1127
MTA1 metastasis associated 1 -2.10972
ATP5PD ATP synthase peripheral stalk subunit d -2.1021
COL17A1 collagen, type XVII, alpha 1 -2.1011
ERCC2 excision repair cross-complementation group 2 -2.10085
RUSF1 RUS family member 1 -2.09815
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) -2.09535
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.0936
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -2.08965
TMEM214 transmembrane protein 214 -2.0843
RCC1L RCC1 like -2.0826
TFDP1 transcription factor Dp-1 -2.07915
STXBP2 syntaxin binding protein 2 -2.0784
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.0769
MAP2K2 mitogen-activated protein kinase kinase 2 -2.07237
CTSZ cathepsin Z -2.0621
TNIP1 TNFAIP3 interacting protein 1 -2.05705
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.0514
INPPL1 inositol polyphosphate phosphatase-like 1 -2.0477
FURIN furin (paired basic amino acid cleaving enzyme) -2.04765
SCARB1 scavenger receptor class B, member 1 -2.04667
ESRRA estrogen-related receptor alpha -2.0447
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.0363
SCAMP2 secretory carrier membrane protein 2 -2.0357
MRPS18B mitochondrial ribosomal protein S18B -2.0311
PTBP1 polypyrimidine tract binding protein 1 -2.02736
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.02635
PEX10 peroxisomal biogenesis factor 10 -2.02507
HELZ helicase with zinc finger -2.0247
MRPL23 mitochondrial ribosomal protein L23 -2.02335
MAPK3 mitogen-activated protein kinase 3 -2.023
CAPNS1 calpain, small subunit 1 -2.016
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.01487
LGALSL lectin, galactoside-binding-like -2.012
F2RL1 coagulation factor II (thrombin) receptor-like 1 -2.01157
MRPL4 mitochondrial ribosomal protein L4 -2.01005
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -2.00458
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.00045